Blar i Bergen Open Research Archive på forfatter "Herold-Mende, Christel"

Viser treff 1-5 av 5

    • AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion 

      Schuster, Anne; Klein, Eliane; Neirinckx, Virginie; Møldrup Knudsen, Arnon; Fabian, Carina; Hau, Ann-Christin; Dieterle, Monika; Oudin, Anaïs; Nazarov, Petr V.; Golebiewska, Anna; Muller, Arnaud; Perez-Hernandez, Daniel; Rhodius, Sophie; Dittmar, Gunnar; Bjerkvig, Rolf; Herold-Mende, Christel; Klink, Barbara; Winther Kristensen, Bjarne; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020)
      The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic ...

    • Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin 

      Biedermann, Julia; Preussler, Mathias; Conde, Marina; Peitzsch, Mirko; Richter, Susan; Wiedemuth, Ralf; Abou-El-Ardat, Khalil; Krüger, Alexander; Meinhardt, Mathias; Schackert, Gabriele; Leenders, William P.J.; Herold-Mende, Christel; Niclou, Simone Pierrette; Bjerkvig, Rolf; Eisenhofer, Graeme; Temme, Achim; Seifert, Michael; Kunz-Schughart, Leoni A.; Schröck, Evelin; Klink, Barbara (Peer reviewed; Journal article, 2019-12-16)
      IDH1R132H (isocitrate dehydrogenase 1) mutations play a key role in the development of low-grade gliomas. IDH1wt converts isocitrate to α-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+), ...

    • Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology 

      Golebiewska, Anna; Hau, Ann-Christin; Oudin, Anaïs; Stieber, Daniel; Yabo, Yahaya A.; Baus, Virginie; Barthelemy, Vanessa; Klein, Eliane; Bougnaud, Sébastien; Keunen, Olivier; Wantz, May; Michelucci, Alessandro; Neirinckx, Virginie; Muller, Arnaud; Kaoma, Tony; Nazarov, Petr V.; Azuaje, Francisco; De Falco, Alfonso; Flies, Ben; Richart, Lorraine; Poovathingal, Suresh K; Arns, Thais; Grzyb, Kamil; Mock, Andreas; Herold-Mende, Christel; Steino, Anne; Brown, Dennis; May, Patrick; Miletic, Hrvoje; Malta, Tathiane M.; Noushmehr, Houtan; Kwon, Yong-Jun; Jahn, Winnie; Klink, Barbara; Tanner, Georgette; Stead, Lucy F.; Mittelbronn, Michel; Skupin, Alexander; Hertel, Frank; Bjerkvig, Rolf; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020)
      Patient-based cancer models are essential tools for studying tumor biology and for the assessment of drug responses in a translational context. We report the establishment a large cohort of unique organoids and patient-derived ...

    • Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment 

      Dirkse, Anna; Golebiewska, Anna; Buder, Thomas; Nazarov, Petr V.; Muller, Arnaud; Poovathingal, Suresh K.; Brons, Nicolaas H. C.; Leite, Sonia; Sauvageot, Nicolas; Sarkisjan, Dzjemma; Seyfrid, Mathieu; Fritah, Sabrina; Stieber, Daniel; Michelucci, Alesandro; Hertel, Frank; Herold-Mende, Christel; Azuaje, Francisco; Skupin, Alexander; Bjerkvig, Rolf; Deutsch, Andreas; Voss-Böhme, Anja; Niclou, Simone Pierrette (Peer reviewed; Journal article, 2019-04-16)
      The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and resistance have been challenged in brain tumors. Here we report that cells expressing CSC-associated cell membrane markers in Glioblastoma ...

    • Temozolomide-induced rna interactome uncovers novel lncrna regulatory loops in glioblastoma 

      Fritah, Sabrina; Muller, Arnaud; Jiang, Wei; Mitra, Ramkrishna; Sarmini, Mohamad; Dieterle, Monika; Golebiewska, Anna; Ye, Tao; van Dyck, Eric; Herold-Mende, Christel; Zhao, Zhongming; Azuaje, Francisco; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020-09-10)
      Resistance to chemotherapy by temozolomide (TMZ) is a major cause of glioblastoma (GBM) recurrence. So far, attempts to characterize factors that contribute to TMZ sensitivity have largely focused on protein-coding genes, ...