Browsing Bergen Open Research Archive by Author "Hervig, Tor"
Now showing items 1-10 of 10
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Cold-stored whole blood in a Norwegian emergency helicopter service: an observational study on storage conditions and product quality
Bjerkvig, Christopher Kalhagen; Sivertsen, Joar; Bråthen, Hanne Kristin; Lunde, Turid Helen Felli; Strandenes, Geir; Assmus, Jörg; Hervig, Tor; Cap, Andrew P.; Kristoffersen, Einar Klæboe; Fosse, Theodor; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2020)BACKGROUND Increasing numbers of emergency medical service agencies and hospitals are developing the capability to administer blood products to patients with hemorrhagic shock. Cold‐stored whole blood (WB) is the only ... -
Environmental pollutants in blood donors: The multicentre Norwegian donor study
Averina, Maria; Hervig, Tor; Huber, Sandra; Kjær, Mette; Kristoffersen, Einar Klæboe; Bolann, Bjørn Johan (Journal article; Peer reviewed, 2020)Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood ... -
Immunomodulation induced by stem cell mobilization and harvesting in healthy donors: Increased systemic osteopontin levels after treatment with granulocyte colony-stimulating factor
Melve, Guro Kristin; Ersvær, Elisabeth; Akkøk, Cigdem Ahaein; Ahmed, Aymen B; Kristoffersen, Einar Klæboe; Hervig, Tor; Bruserud, Øystein (Peer reviewed; Journal article, 2016-07-19)Peripheral blood stem cells from healthy donors mobilized by granulocyte colony-stimulating factor (G-CSF) and harvested by leukapheresis are commonly used for allogeneic stem cell transplantation. The frequency of severe ... -
Influence of platelet storage time on human platelet lysates and platelet lysate-expanded mesenchymal stromal cells for bone tissue engineering
Shanbhag, Siddharth; Mohamed Ahmed, Samih; Lunde, Turid Helen Felli; Suliman, Salwa; Bolstad, Anne Isine; Hervig, Tor; Mustafa, Kamal Babikeir Eln (Journal article; Peer reviewed, 2020)Background Human platelet lysate (HPL) is emerging as the preferred xeno-free supplement for the expansion of mesenchymal stromal cells (MSCs) for bone tissue engineering (BTE) applications. Due to a growing demand, the ... -
Platelet microparticles decrease daunorubicin‐induced dna damage and modulate intrinsic apoptosis in thp‐1 cells
Cacic, Daniel; Nordgård, Oddmund; Meyer, Peter Albert; Hervig, Tor (Journal article; Peer reviewed, 2021)Platelets can modulate cancer through budding of platelet microparticles (PMPs) that can transfer a plethora of bioactive molecules to cancer cells upon internalization. In acute myelogenous leukemia (AML) this can induce ... -
Platelet Microparticles Protect Acute Myelogenous Leukemia Cells against Daunorubicin-Induced Apoptosis
Cacic, Daniel; Reikvam, Håkon; Nordgård, Oddmund; Meyer, Peter; Hervig, Tor (Journal article; Peer reviewed, 2021)The role of platelets in cancer development and progression is increasingly evident, and several platelet–cancer interactions have been discovered, including the uptake of platelet microparticles (PMPs) by cancer cells. ... -
Platelets for advanced drug delivery in cancer
Cacic, Daniel Limi; Hervig, Tor; Reikvam, Håkon (Journal article; Peer reviewed, 2023)Introduction: Cancer-related drug expenses are rising with the increasing cancer incidence and cost may represent a severe challenge for drug access for patients with cancer. Consequently, strategies for increasing therapeutic ... -
Prehospital Whole Blood Transfusion Programs in Norway
Bjerkvig, Christopher Kalhagen; Strandenes, Geir; Hervig, Tor; Sunde, Geir Arne; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2021)Background: Prehospital management of severe hemorrhage has evolved significantly in Norwegian medical emergency services in the last 10 years. Treatment algorithms for severe bleeding were previously focused on restoration ... -
A prospective, active haemovigilance study with combined cohort analysis of 19 175 transfusions of platelet components prepared with amotosalen-UVA photochemical treatment
Knutson, Folkre; Osselaer, Jean Claude; Pierelli, Luca; Lozano, Miguel; Cid, Joan Rodríguez; Tardivel, René H.; Garraud, Olivier; Hervig, Tor; Domanović, Dragoslav; Cukjati, Marko; Gudmundsson, Sveinn; Hjálmarsdóttir, Ína B.; Castrillo, Azucena; González, Rocío; Brihante, Dialina; Santos, Marlene; Schlenke, Peter; Elliott, Anne; Lin, Jin-Sying; Tappe, David; Stassinopoulos, Adonis; Green, Jennifer M.; Corash, Larry (Peer reviewed; Journal article, 2015-05-15)Background and Objectives: A photochemical treatment process (PCT) utilizing amotosalen and UVA light (INTERCEPT™ Blood System) has been developed for inactivation of viruses, bacteria, parasites and leucocytes that can ... -
A whole blood based resuscitation strategy in civilian medical services: Experience from a Norwegian hospital in the period 2017–2020
Hagen, Kristin Gjerde; Strandenes, Geir; Kristoffersen, Einar Klæboe; Braathen, Hanne; Sivertsen, Joar; Bjerkvig, Christopher Kalhagen; Sommerfelt-Pettersen, Nina Grindheim; Aasheim, Irmelin Beathe; Lunde, Turid Helen Felli; Hervig, Tor; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2021)Background: Civilian and military guidelines recommend early balanced transfusion to patients with life-threatening bleeding. Low titer group O whole blood was introduced as the primary blood product for resuscitation of ...