Blar i Bergen Open Research Archive på forfatter "Holt, Kathryn E."
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Convergence of virulence and MDR in a single plasmid vector in MDR Klebsiella pneumoniae ST15
Lam, Margaret M.C.; Wyres, Kelly L.; Wick, Ryan R.; Judd, Louise M.; Fostervold, Aasmund; Holt, Kathryn E.; Löhr, Iren Høyland (Peer reviewed; Journal article, 2019)Background: MDR and hypervirulence (hv) are typically observed in separate Klebsiella pneumoniae populations. However, convergent strains with both properties have been documented and potentially pose a high risk to public ... -
Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307
Wyres, Kelly L.; Hawkey, Jane; Hetland, Marit; Fostervold, Aasmund; Wick, Ryan R.; Judd, Louise M.; Hamidian, Mohammad; Howden, Benjamin P.; Löhr, Iren Høyland; Holt, Kathryn E. (Peer reviewed; Journal article, 2019)Objectives: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its ... -
Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity
Raffelsberger, Niclas Peter; Hetland, Marit Andrea Klokkhammer; Svendsen, Kristian; Småbrekke, Lars; Löhr, Iren Høyland; Andreassen, Lotte; Brisse, Sylvain; Holt, Kathryn E.; Sundsfjord, Arnfinn; Samuelsen, Ørjan; Gravningen, Kirsten Midttun (Journal article; Peer reviewed, 2021)Antibiotic resistant Klebsiella pneumoniae is a leading public health threat and gastrointestinal carriage is an established risk factor for subsequent infections during hospitalization. Our study contributes new knowledge ... -
A nationwide genomic study of clinical Klebsiella pneumoniae in Norway 2001–15: introduction and spread of ESBLs facilitated by clonal groups CG15 and CG307
Fostervold, Aasmund; Hetland, Marit Andrea Klokkhammer; Bakksjø, Ragna-Johanne; Bernhoff, Eva; Holt, Kathryn E.; Samuelsen, Ørjan; Simonsen, Gunnar Skov; Sundsfjord, Arnfinn; Wyres, Kelly L.; Löhr, Iren Høyland (Journal article; Peer reviewed, 2022)Objectives To use the nationwide Norwegian surveillance programme on resistant microbes in humans (NORM) to address longitudinal changes in the population structure of Klebsiella pneumoniae isolates from 2001–15, focusing ... -
Within-patient and global evolutionary dynamics of Klebsiella pneumoniae ST17
Hetland, Marit; Hawkey, Jane; Bernhoff, Eva; Bakksjø, Ragna-Johanne; Kaspersen, Håkon; Rettedal, Siren; Sundsfjord, Arnfinn; Holt, Kathryn E.; Löhr, Iren Høyland (Journal article; Peer reviewed, 2023)Klebsiella pneumoniae sequence type (ST) 17 is a global problem clone that causes multidrug-resistant (MDR) hospital infections worldwide. In 2008–2009, an outbreak of MDR ST17 occurred at a neonatal intensive care unit ...