• Adults with attention-deficit/hyperactivity disorder. A brain magnetic resonance spectroscopy study 

      Dramsdahl, Margaretha; Ersland, Lars; Plessen, Kerstin von; Haavik, Jan; Hugdahl, Kenneth; Specht, Karsten (Peer reviewed; Journal article, 2011-11-23)
      Background: Impaired cognitive control in individuals with attention-deficit/hyperactivity disorder (ADHD) may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the ...
    • Assessing brain structural associations with working-memory related brain patterns in schizophrenia and healthy controls using linked independent component analysis 

      Brandt, Christine Lycke; Doan, Nhat Trung; Tønnesen, Siren; Agartz, Ingrid; Hugdahl, Kenneth; Melle, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2015)
      Schizophrenia (SZ) is a psychotic disorder with significant cognitive dysfunction. Abnormal brain activation during cognitive processing has been reported, both in task-positive and task-negative networks. Further, structural ...
    • The association of PTSD symptom severity with amygdala nuclei volumes in traumatized youths 

      Ousdal, Olga Therese; Milde, Anne Marita; Hafstad, Gertrud Sofie; Hodneland, Erlend; Dyb, Grete; Craven, Alexander R.; Melinder, Annika Maria D; Endestad, Tor; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020)
      The amygdala is a core component in neurobiological models of stress and stress-related pathologies, including post-traumatic stress disorder (PTSD). While numerous studies have reported increased amygdala activity following ...
    • Auditory hallucinations, top-down processing and language perception: a general population study 

      de Boer, Janna N.; Linszen, Mascha M.J.; de Vries, J. Hans; Schutte, Maya J.L.; Begemann, Marieke J.H.; Heringa, Sophie M.; Bohlken, Marc Marijn; Hugdahl, Kenneth; Aleman, André; Wijnen, Frank N.K.; Sommer, Iris Else Clara (Peer reviewed; Journal article, 2019)
      Background: Studies investigating the underlying mechanisms of hallucinations in patients with schizophrenia suggest that an imbalance in top-down expectations v. bottom-up processing underlies these errors in perception. ...
    • Behavioral measures of attention and cognitive control during a new auditory working memory paradigm 

      Kayser, Jurgen; Wong, Lidia Y X; Sacchi, Elizabeth; Casal-Roscum, Lindsey; Alvarenga, Jorge E; Hugdahl, Kenneth; Bruder, Gerard E; Jonides, John (Peer reviewed; Journal article, 2019-12-03)
      Proactive control is the ability to manipulate and maintain goal-relevant information within working memory (WM), allowing individuals to selectively attend to important information while inhibiting irrelevant distractions. ...
    • Beyond trauma: A multiple pathways approach to auditory hallucinations in clinical and nonclinical populations 

      Luhrmann, Tanya Marie; Alderson-Day, Ben; Bell, Vaughan; Bless, Josef J; Corlett, Philip; Hugdahl, Kenneth; Jones, Nev; Larøi, Frank; Mosley, Peter; Padmavati, Ramachandran; Peters, Emmanuelle; Powers, Albert R.; Waters, Flavie (Peer reviewed; Journal article, 2019-02-01)
      That trauma can play a significant role in the onset and maintenance of voice-hearing is one of the most striking and important developments in the recent study of psychosis. Yet the finding that trauma increases the risk ...
    • Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study 

      Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Nhat Trung, Doan; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Schizophrenia Project (KaSP), Karolinska; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2020)
      Background Schizophrenia (SZ) and bipolar disorder (BD) share substantial neurodevelopmental components affecting brain maturation and architecture. This necessitates a dynamic lifespan perspective in which brain aberrations ...
    • “Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited” 

      Brix, Maiken Kirkegaard; Ersland, Lars; Hugdahl, Kenneth; Grüner, Renate; Posserud, Maj-Britt; Hammar, Åse; Craven, Alexander R.; Noeske, Ralph; Evans, C. John; Walker, Hanne B.; Midtvedt, Tore; Beyer, Mona K. (Peer reviewed; Journal article, 2015-06-22)
      Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) ...
    • Children with dyslexia show cortical hyperactivation in response to increasing literacy processing demands 

      Morken, Frøydis; Helland, Turid; Hugdahl, Kenneth; Specht, Karsten (Peer reviewed; Journal article, 2014-12-22)
      This fMRI study aimed to examine how differences in literacy processing demands may affect cortical activation patterns in 11- to 12-year-old children with dyslexia as compared to children with typical reading skills. ...
    • Combined fMRI Region- and Network-Analysis Reveal New Insights of Top-Down Modulation of Bottom-Up Processes in Auditory Laterality 

      Kazimierczak, Katarzyna; Craven, Alexander R.; Ersland, Lars; Specht, Karsten; Dumitru, Magda L.; Sandøy, Lydia B.; Hugdahl, Kenneth (Journal article; Peer reviewed, 2022)
      Dichotic listening along with the right-ear advantage (REA) has been a standard method of investigating auditory laterality ever since it was first introduced into neuropsychology in the early 1960s. Beginning in the 1980s, ...
    • Comparison of seven modelling algorithms for γ-aminobutyric acid–edited proton magnetic resonance spectroscopy 

      Craven, Alexander R.; Bhattacharyya, Pallab K.; Clarke, William T.; Dydak, Ulrike; Edden, Richard A.E.; Ersland, Lars; Mandal, Pravat K.; Mikkelsen, Mark; Murdoch, James B.; Near, Jamie; Rideaux, Reuben; Shukla, Deepika; Wang, Min; Wilson, Martin; Zöllner, Helge J.; Hugdahl, Kenneth; Oeltzschner, Georg (Journal article; Peer reviewed, 2022)
      Edited MRS sequences are widely used for studying γ-aminobutyric acid (GABA) in the human brain. Several algorithms are available for modelling these data, deriving metabolite concentration estimates through peak fitting ...
    • A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation 

      Kroken, Rune; Løberg, Else-Marie; Drønen, Tore; Grüner, Renate; Hugdahl, Kenneth; Kompus, Kristiina; Skrede, Silje; Johnsen, Erik (Peer reviewed; Journal article, 2014-02-04)
      Antipsychotic drugs have thus far focused on dopaminergic antagonism at the D2 receptors, as counteracting the hyperdopaminergia in nigrostriatal and mesolimbic projections has been considered mandatory for the antipsychotic ...
    • Default-mode network functional connectivity is closely related to metabolic activity 

      Passow, Susanne; Specht, Karsten; Adamsen, Tom Christian; Biermann, Martin; Brekke, Njål; Craven, Alexander R.; Ersland, Lars; Grüner, Renate; Kleven-Madsen, Nina; Kvernenes, Ole Heine; Schwarzlmüller, Thomas; Olesen, Rasmus Aamand; Hugdahl, Kenneth (Peer reviewed; Journal article, 2015-06)
      Over the last decade, the brain's default-mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more ...
    • Development of Performance and ERPs in a Flanker Task in Children and Adolescents with Tourette Syndrome—A Follow-Up Study 

      Eichele, Heike; Eichele, Tom; Marquardt, Lynn; Adolfsdottir, Steinunn; Hugdahl, Kenneth; Sørensen, Lin; Plessen, Kerstin J. (Peer reviewed; Journal article, 2017-06-12)
      Background: Tourette Syndrome (TS) is a neurodevelopmental disorder with childhood-onset, with a typical decline in tic severity, as well as an increasing ability to suppress tics in late childhood and adolescence. These ...
    • Dynamic Functional Connectivity Patterns in Schizophrenia and the Relationship With Hallucinations 

      Weber, Sarah; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Kandilarova, Sevdalina; Stoyanov, Drozdstoy; Kompus, Kristiina; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020)
      There is a wealth of evidence showing aberrant functional connectivity (FC) in schizophrenia but with considerable variability in findings across studies. Dynamic FC is an extension of traditional static FC, in that such ...
    • Dynamic switching between intrinsic and extrinsic mode networks as demands change from passive to active processing 

      Riemer, Frank; Gruner, Eli Renate; Beresniewicz, Justyna; Kazimierczak, Katarzyna Anna; Ersland, Lars; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020-12-08)
      In this study we report on the relationship between default and extrinsic mode networks across alternating brief periods of rest and active task processing. Three different visual tasks were used in a classic fMRI ON–OFF ...
    • Dynamic up- and down-regulation of thedefault (DMN) and extrinsic (EMN) modenetworks during alternating task-on and task-offperiods 

      Hugdahl, Kenneth; Kazimierczak, Katarzyna Anna; Beresniewicz, Justyna; Kompus, Kristiina; Westerhausen, René; Ersland, Lars; Grüner, Renate; Specht, Karsten (Peer reviewed; Journal article, 2019)
      Using fMRI, Hugdahl et al. (2015) reported the existence of a general-domain cortical network during active task-processing which was non-specific to the cognitive task being processed. They labelled this network the ...
    • The effects of alcohol intoxication on neuronal activation at different levels of cognitive load 

      Gundersen, Hilde; Grüner, Renate; Specht, Karsten; Hugdahl, Kenneth (Peer reviewed; Journal article, 2008-08-22)
      The aim of this study was to investigate how alcohol intoxication at two blood alcohol concentrations (BAC) affected neuronal activation during increasing levels of cognitive load. For this purpose we used functional ...
    • Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function 

      Oltedal, Leif; Kessler, Ute; Ersland, Lars; Grüner, Renate; Andreassen, Ole Andreas; Haavik, Jan; Hoff, Per Ivar; Hammar, Åsa; Dale, Anders Martin; Hugdahl, Kenneth; Ødegaard, Ketil Joachim (Peer reviewed; Journal article, 2015-05-01)
      Background Major depression can be a serious and debilitating condition. For some patients in a treatment resistant depressive episode, electroconvulsive treatment (ECT) is the only treatment that is effective. Although ...
    • Efficacy of different types of cognitive enhancers for patients with schizophrenia: a meta-analysis 

      Sinkeviciute, Igne; Begemann, Marieke; Prikken, Merel; Oranje, Bob; Johnsen, Erik; Lei, Wan U.; Hugdahl, Kenneth; Kroken, Rune Andreas; Rau, Carina; Jacobs, Jolien D.; Mattaroccia, Silvia; Sommer, Iris Else Clara (Peer reviewed; Journal article, 2018)
      Cognitive impairment is a core feature of schizophrenia, which is predictive for functional outcomes and is, therefore, a treatment target in itself. Yet, literature on efficacy of different pharmaco-therapeutic options ...