Browsing Bergen Open Research Archive by Author "Hultström, Michael"
Now showing items 1-5 of 5
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Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats
Leh, Sabine Maria; Hultström, Michael; Rosenberger, Christian; Iversen, Bjarne M. (Peer reviewed; Journal article, 2011-06-10)In chronic renal disease, the temporal and spatial relationship between vascular, glomerular and tubular changes is still unclear. Hypertension, an important cause of chronic renal failure, leads to afferent arteriolopathy, ... -
Deletion of Notch3 Impairs Contractility of Renal Resistance Vessels Due to Deficient Ca2+ Entry
Helle, Frank; Hultström, Michael; Kavvadas, Panagiotis; Iversen, Bjarne Magnus; Chadjichristos, Christos E.; Chatziantoniou, Christos (Journal article; Peer reviewed, 2022)Notch3 plays an important role in the differentiation and development of vascular smooth muscle cells. Mice lacking Notch3 show deficient renal autoregulation. The aim of the study was to investigate the mechanisms involved ... -
Matrix metalloproteinase-2 knockout and heterozygote mice are protected from hydronephrosis and kidney fibrosis after unilateral ureteral obstruction
Tveitarås, Maria Kathrine; Skogstrand, Trude; Leh, Sabine Maria; Helle, Frank; Iversen, Bjarne Magnus; Chatziantoniou, Christos; Reed, Rolf K.; Hultström, Michael (Peer reviewed; Journal article, 2015-12-16)Matrix Metalloproteinase-2 (Mmp2) is a collagenase known to be important in the development of renal fibrosis. In unilateral ureteral obstruction (UUO) the obstructed kidney (OK) develops fibrosis, while the contralateral ... -
Prevention of Hypertension and Organ Damage in 2-Kidney, 1-Clip Rats by Tetradecylthioacetic Acid
Gudbrandsen, Oddrun Anita; Hultström, Michael; Leh, Sabine Maria; Bivol, Liliana Monica; Vågnes, Øyvind; Berge, Rolf Kristian; Iversen, Bjarne M. (Peer reviewed; Journal article, 2006-07-17)Dietary lipids are reported to affect the blood pressure in both humans and experimental animal models with hypertension. In the present study, 2-kidney, 1-clip (2K1C) hypertensive rats were treated with the modified fatty ... -
Time course of decompensation after angiotensin II and high-salt diet in Balb/CJ mice suggests pulmonary hypertension-induced cardiorenal syndrome
Becirovic-Agic, Mediha; Jönsson, Sofia; Tveitarås, Maria Kathrine; Skogstrand, Trude; Karlsen, Tine Veronica; Liden, Åsa; Leh, Sabine Maria; Ericsson, Madelene; Nilsson, Stefan K.; Reed, Rolf K.; Hultström, Michael (Peer reviewed; Journal article, 2019-05-01)The genetic background of a mouse strain determines its susceptibility to disease. C57BL/6J and Balb/CJ are two widely used inbred mouse strains that we found react dramatically differently to angiotensin II and high-salt ...