Browsing Bergen Open Research Archive by Author "Indelicato, Daniel J."
Now showing items 1-5 of 5
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A case-control study of linear energy transfer and relative biological effectiveness related to symptomatic brainstem toxicity following pediatric proton therapy
Fjæra, Lars Fredrik; Indelicato, Daniel J.; Handeland, Andreas Havsgård; Ytre-Hauge, Kristian Smeland; Lassen-Ramshad, Yasmin; Muren, Ludvig Paul; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2022)Background and purpose A fixed relative biological effectiveness (RBE) of 1.1 (RBE1.1) is used clinically in proton therapy even though the RBE varies with properties such as dose level and linear energy transfer (LET). ... -
Implementation of a double scattering nozzle for Monte Carlo recalculation of proton plans with variable relative biological effectiveness
Fjæra, Lars Fredrik; Indelicato, Daniel J.; Stokkevåg, Camilla Hanquist; Muren, Ludvig Paul; Hsi, Wen C.; Ytre-Hauge, Kristian (Journal article; Peer reviewed, 2020)A constant relative biological effectiveness (RBE) of 1.1 is currently used in clinical proton therapy. However, the RBE varies with factors such as dose level, linear energy transfer (LET) and tissue type. Multiple RBE ... -
Linear energy transfer-inclusive models of brainstem necrosis following proton therapy of paediatric ependymoma
Handeland, Andreas Havsgård; Indelicato, Daniel J.; Fjæra, Lars Fredrik; Ytre-Hauge, Kristian Smeland; Pettersen, Helge Egil Seime; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2023)Background and Purpose Radiation-induced brainstem necrosis after proton therapy is a severe toxicity with potential association to uncertainties in the proton relative biological effectiveness (RBE). A constant RBE of ... -
Spatial Agreement of Brainstem Dose Distributions Depending on Biological Model in Proton Therapy for Pediatric Brain Tumors
Fjæra, Lars Fredrik; Indelicato, Daniel J.; Ytre-Hauge, Kristian; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Toussaint, Laura; Dahl, Olav; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2021)Purpose During radiation therapy for pediatric brain tumors, the brainstem is a critical organ at risk, possibly with different radio-sensitivity across its substructures. In proton therapy, treatment planning is currently ... -
Variation in relative biological effectiveness for cognitive structures in proton therapy of pediatric brain tumors
Otterlei, Ole Marius; Indelicato, Daniel J.; Toussaint, Laura; Ytre-Hauge, Kristian; Pilskog, Sara; Fjæra, Lars Fredrik; Rørvik, Eivind; Pettersen, Helge Egil Seime; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Di Pinto, Marcos; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2021)Background Clinically, a constant value of 1.1 is used for the relative biological effectiveness (RBE) of protons, whereas in vitro the RBE has been shown to vary depending on physical dose, tissue type, and linear energy ...