Blar i Bergen Open Research Archive på forfatter "Isaksson, Johan"
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The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection
Dobrovolska, Olena; Brilkov, Maxim; Madeleine, Noëlly; Ødegaard-Fougner, Øyvind; Strømland, Øyvind; Martin, Stephen R.; De Marco, Valeria; Christodoulou, Evangelos; Teigen, Knut; Isaksson, Johan; Underhaug, Jarl; Reuter, Nathalie; Aalen, Reidunn B.; Aasland, Rein; Halskau, Øyvind (Journal article; Peer reviewed, 2020)Chromatin post‐translational modifications are thought to be important for epigenetic effects on gene expression. Methylation of histone N‐terminal tail lysine residues constitutes one of many such modifications, executed ... -
Kinase chemodiversity from the Arctic: the breitfussins
Østnes Hansen, Kine; Andersen, Jeanette hammer; Bayer, Annette; Pandey, Sunil Kumar; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav; Guttormsen, Yngve; Baumann, Matthias; Koch, Uwe; Klebl, Bert; Eickhoff, Jan; Haug, Bengt Erik; Isaksson, Johan; Hansen, Espen (Peer reviewed; Journal article, 2019)In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of natural products is a promising scaffold for kinase inhibition. Six new halogenated natural products, breitfussin C–H (3 ... -
Spatial immunophenotyping of the tumour microenvironment in non–small cell lung cancer
Backman, Max; Strell, Carina; Lindberg, Amanda; Mattsson, Johanna S.M.; Elfving, Hedvig; Brunnström, Hans; O'Reilly, Aine; Bosic, Martina; Gulyas, Miklos; Isaksson, Johan; Botling, Johan; Kärre, Klas; Jirström, Karin; Lamberg, Kristina; Pontén, Fredrik; Leandersson, Karin; Mezheyeuski, Artur; Micke, Patrick (Journal article; Peer reviewed, 2023)Introduction: Immune cells in the tumour microenvironment are associated with prognosis and response to therapy. We aimed to comprehensively characterise the spatial immune phenotypes in the mutational and clinicopathological ... -
Total Synthesis of Phorbazole B
Guttormsen, Yngve; Fairhurst, Magnus John Espeland; Pandey, Sunil Kumar; Isaksson, Johan; Haug, Bengt Erik; Bayer, Annette (Journal article; Peer reviewed, 2020)Phorbazoles are polychlorinated heterocyclic secondary metabolites isolated from a marine sponge and several of these natural products have shown inhibitory activity against cancer cells. In this work, a synthesis of the ... -
Unequivocal structure confirmation of a breitfussin analog by anisotropic NMR measurements
Ndukwe, Ikenna E.; Lam, Yu-hong; Pandey, Sunil Kumar; Haug, Bengt Erik; Bayer, Annette; Sherer, Edward C.; Blinov, Kirill A.; Williamson, R. Thomas; Isaksson, Johan; Reibarkh, Mikhail; Liu, Yizhou; Martin, Gary E. (Journal article; Peer reviewed, 2020)Structural features of proton-deficient heteroaromatic natural products, such as the breitfussins, can severely complicate their characterization by NMR spectroscopy. For the breitfussins in particular, the constitution ...