Browsing Bergen Open Research Archive by Author "Jänis, Janne"
Now showing items 1-3 of 3
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Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism
Bustad, Helene J.; Kallio, Juha Pekka; Laitaoja, Mikko; Toska, Karen; Kursula, Inari; Martinez, Aurora; Jänis, Janne (Journal article; Peer reviewed, 2021)Porphobilinogen deaminase (PBGD), the third enzyme in the heme biosynthesis, catalyzes the sequential coupling of four porphobilinogen (PBG) molecules into a heme precursor. Mutations in PBGD are associated with acute ... -
Compositions of dissolved organic matter in the ice-covered waters above the Aurora hydrothermal vent system, Gakkel Ridge, Arctic Ocean
Sert, Muhammed Fatih; Niemann, Helge; Reeves, Eoghan; Granskog, Mats A.; Hand, Kevin P.; Kekäläinen, Timo; Jänis, Janne; Rossel, Pamela; Ferré, Benedicte; Silyakova, Anna; Gründger, Friederike (Journal article; Peer reviewed, 2022)Hydrothermal vents modify and displace subsurface dissolved organic matter (DOM) into the ocean. Once in the ocean, this DOM is transported together with elements, particles, dissolved gases and biomass along with the ... -
One ring closer to a closure: the crystal structure of the ES<inf>3</inf> hydroxymethylbilane synthase intermediate
Bustad, Helene J.; Sæter, Marthe Christie; Laitaoja, Mikko; Aarsand, Aasne Karine; Martinez, Aurora; Jänis, Janne; Kallio, Juha Pekka (Journal article; Peer reviewed, 2023)Hydroxymethylbilane synthase (HMBS), involved in haem biosynthesis, catalyses the head-to-tail coupling of four porphobilinogens (PBGs) via a dipyrromethane (DPM) cofactor. DPM is composed of two PBGs, and a hexapyrrole ...