• Bioactive Metabolites of Marine Origin Have Unusual Effects on Model Membrane Systems 

      Jakubec, Martin; Totland, Christian; Rise, Frode; Chamgordani, Elahe Jafari; Paulsen, Britt; Maes, Louis; Matheeussen, An; Gundersen, Lise-Lotte; Halskau, Øyvind (Journal article; Peer reviewed, 2020)
      Marine sponges and soft corals have yielded novel compounds with antineoplastic and antimicrobial activities. Their mechanisms of action are poorly understood, and in most cases, little relevant experimental evidence is ...
    • The biosynthesis of phospholipids is linked to the cell cycle in a model eukaryote 

      Vitova, Milada; Lanta, Vojtech; Cizkova, Maria; Jakubec, Martin; Rise, Frode; Halskau, Øyvind; Bisova, Katerina; Furse, Samuel Robert (Journal article; Peer reviewed, 2021)
      The structural challenges faced by eukaryotic cells through the cell cycle are key for understanding cell viability and proliferation. We tested the hypothesis that the biosynthesis of structural lipids is linked to the ...
    • Cholesterol-containing lipid nanodiscs promote an α-synuclein binding mode that accelerates oligomerization 

      Jakubec, Martin; Bariås, Espen; Furse, Samuel Robert; Govasli Larsen, Morten Andreas; George, Vinnit; Turcu, Diana Cornelia; Iashchishyn, Igor A.; Morozova-Roche, Ludmilla A.; Halskau, Øyvind (Journal article; Peer reviewed, 2021)
      Dysregulation of the biosynthesis of cholesterol and other lipids has been implicated in many neurological diseases, including Parkinson's disease. Misfolding of α-synuclein (α-Syn), the main actor in Parkinson's disease, ...
    • Detection of misfolded protein aggregates from a clinical perspective 

      Jakubec, Martin; Strømland, Øyvind; Furse, Samuel Robert; Halskau, Øyvind (Peer reviewed; Journal article, 2016)
      Neurodegenerative Protein Misfolding Diseases (PMDs), such as Alzheimer’s (AD), Parkinson’s (PD) and prion diseases, are generally difficult to diagnose before irreversible damage to the central nervous system damage has ...
    • Evidence that Listeria innocua modulates its membrane’s stored curvature elastic stress, but not fluidity, through the cell cycle 

      Furse, Samuel Robert; Jakubec, Martin; Rise, Frode; Williams, Huw E.; Rees, Catherine E.D.; Halskau, Øyvind (Peer reviewed; Journal article, 2017-08-14)
      This paper reports that the abundances of endogenous cardiolipin and phosphatidylethanolamine halve during elongation of the Gram-positive bacterium Listeria innocua. The lyotropic phase behaviour of model lipid systems ...
    • Fast and Quantitative Phospholipidomic Analysis of SH-SY5Y Neuroblastoma Cell Cultures Using LC-MS/MS and 31P NMR 

      Jakubec, Martin; Bariås, Espen; Kryuchkov, Fedor; Hjørnevik, Linda Veka; Halskau, Øyvind (Peer reviewed; Journal article, 2019)
      Global lipid analysis still lags behind proteomics with respect to the availability of databases, experimental protocols, and specialized software. Determining the lipidome of cellular model systems in common use is of ...
    • Investigating the Disordered and Membrane-Active Peptide A-Cage-C Using Conformational Ensembles 

      Dobrovolska, Olena; Strømland, Øyvind; Handegård, Ørjan Sele; Jakubec, Martin; Govasli Larsen, Morten Andreas; Skjevik, Åge Aleksander; Frøystein, Nils Åge; Teigen, Knut; Halskau, Øyvind (Journal article; Peer reviewed, 2021)
      The driving forces and conformational pathways leading to amphitropic protein-membrane binding and in some cases also to protein misfolding and aggregation is the subject of intensive research. In this study, a chimeric ...
    • Neuronal cell lipidomics and role of cholesterol in α-synuclein binding and aggregation 

      Jakubec, Martin (Doctoral thesis, 2019-03-22)
      α-Synuclein is an intrinsically disordered protein whose fold and multimeric state is strongly affected by its environment. The monomers of α-synuclein are enriched in the presynaptic terminals of dopaminergic ...
    • Plasma-derived exosome-like vesicles are enriched in lyso-phospholipids and pass the blood-brain barrier 

      Jakubec, Martin; Maple-Grødem, Jodi; Akbari, Saleha; Nesse, Susanne; Halskau, Øyvind; Mork-Jansson, Astrid Elisabeth (Journal article; Peer reviewed, 2020)
      Exosomes are vesicles involved in intercellular communication. Their membrane structure and core content is largely dependent on the cell of origin. Exosomes have been investigated both for their biological roles and their ...