• Association between C-reactive protein levels and antipsychotic treatment during 12 months follow-up period after acute psychosis 

      Fathian, Farivar; Gjestad, Rolf; Kroken, Rune Andreas; Løberg, Else-Marie; Reitan, Solveig Merete Klæbo; Fleichhacker, W. Wolfgang; Rettenbacher, Maria; Larsen, Tor Ketil; Joa, Inge; Stabell, Lena Antonsen; Kjelby, Eirik; Sinkevicute, Igne; Alisauskiene, Renata; Steen, Vidar Martin; Johnsen, Erik (Journal article; Peer reviewed, 2022)
      Background A potential role of inflammatory pathways in the pathology of schizophrenia has been suggested for at least a subgroup of patients. Elevated levels of the inflammatory marker C-reactive protein (CRP) have been ...
    • Can systematic implementation support improve programme fdelity by improving care providers’ perceptions of implementation factors? A cluster randomized trial 

      Hartveit, Miriam; Hovlid, Einar; Øvretveit, John; Assmus, Jörg; Bond, Gary; Joa, Inge; Heiervang, Kristin Sverdvik; Stensrud, Bjørn; Høifødt, Tordis Sørensen; Biringer, Eva Aaker; Ruud, Torleif (Journal article; Peer reviewed, 2022)
      Background Investigations of implementation factors (e.g., collegial support and sense of coherence) are recommended to better understand and address inadequate implementation outcomes. Little is known about the relationship ...
    • Childhood trauma, antipsychotic medication, and symptom remission in first-episode psychosis 

      Ottesen, Akiah; Hegelstad, Wenche; Joa, Inge; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Røssberg, Jan Ivar; Simonsen, Erik; Johannessen, Jan Olav; Larsen, Tor Ketil; Haahr, Ulrik H.; McGlashan, T.H.; Friis, Svein; Melle, Ingrid (Journal article; Peer reviewed, 2021)
      Background: To what extent psychotic symptoms in first-episode psychosis (FEP) with a history of childhood interpersonal trauma (CIT) are less responsive to antipsychotic medication is not known. In this longitudinal study, ...
    • Cognitive change and antipsychotic medications: Results from a pragmatic rater-blind RCT 

      Anda, Liss; Johnsen, Erik; Kroken, Rune A.; Joa, Inge; Rettenbacher, Maria; Løberg, Else-Marie (Journal article; Peer reviewed, 2021)
      Cognitive impairment is a core aspect of psychotic disorders and difficult to treat. Atypical antipsychotics (AAs) might have differential effects on cognitive impairment, but rigid study designs and selective sampling ...
    • Cognitive profile in ultra high risk for psychosis and schizophrenia: A comparison using coordinated norms 

      Anda-Ågotnes, Liss Gøril; Brønnick, Kolbjørn Kallesten; Johannessen, Jan Olav; Joa, Inge; Kroken, Rune Andreas; Johnsen, Erik; Rettenbacher, Maria; Fathian, Farivar; Løberg, Else-Marie (Peer reviewed; Journal article, 2019-10-01)
      Background: Cognitive impairment is not only a core aspect of schizophrenia but also commonly observed in help-seeking youth at ultra high risk for psychosis (UHR), with potential implications for prognosis and individualized ...
    • Differential Effectiveness of Atypical Antipsychotics on Hallucinations: A Pragmatic Randomized Controlled Trial 

      Sinkeviciute, Igne; Hugdahl, Kenneth Jan; Bartz-Johannessen, Christoffer; Kroken, Rune Andreas; Løberg, Else-Marie; Kjelby, Eirik; Rettenbacher, maria; Joa, Inge; Reitan, Solveig Merete Klæbo; Alisauskiene, Renata; Fathian, Farivar; Johnsen, Erik (Journal article; Peer reviewed, 2021-07)
      Background Most studies investigating antipsychotic effectiveness report either total psychopathology or symptom cluster findings. Studies focusing on a separate symptom, such as hallucinations, a hallmark symptom in ...
    • Early substance use cessation improves cognition-10 years outcome in first-episode psychosis patients 

      Weibell, Melissa Anne E; Johannessen, Jan Olav; Auestad, Bjørn Henrik; Bramness, Jørgen Gustav; Brønnick, Kolbjørn Kallesten; Haahr, Ulrik; Joa, Inge; Larsen, Tor Ketil; Melle, Ingrid; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Røssberg, Jan Ivar; Simonsen, Erik; Vaglum, Per; Stain, Helen J.; Friis, Svein; Hegelstad, Wenche (Peer reviewed; Journal article, 2019-07-12)
      Background: Cognitive impairment may be a risk factor for, as well as a consequence of, psychosis. Non-remitting symptoms, premorbid functioning, level of education, and socioeconomic background are known correlates. A ...
    • The Effect of Intensive Implementation Support on Fidelity for Four Evidence‑Based Psychosis Treatments: A Cluster Randomized Trial 

      Ruud, Torleif; Drake, Robert E.; Saltyte Benth, Jurate; Drivenes, Karin; Hartveit, Miriam; Heiervang, Kristin Sverdvik; Høifødt, Tordis Sørensen; Haaland, Vegard Øksendal; Joa, Inge; Johannessen, Jan Olav; Johansen, Karl Johan; Stensrud, Bjørn; Haugom, Espen Woldsengen; Clausen, Hanne Kristin; Biringer, Eva Aaker; Bond, Gary R. (Journal article; Peer reviewed, 2021)
      Purpose Service providers need effective strategies to implement evidence-based practices (EBPs) with high fidelity. This study aimed to evaluate an intensive implementation support strategy to increase fidelity to EBP ...
    • "Everyone Needs a Friend Sometimes" - social predictors of long-term remission in first episode psychosis 

      Bjørnestad, Jone Ravndal; Joa, Inge; Larsen, Tor Ketil; Langeveld, Johannes H.; Davidson, Larry; Hegelstad, Wenche; Anda-Ågotnes, Liss Gøril; Veseth, Marius; Melle, Ingrid; Johannessen, Jan Olav; Brønnick, Kolbjørn Selvåg (Peer reviewed; Journal article, 2016-10-04)
      Background: Predictors of long-term symptomatic remission are crucial to the successful tailoring of treatment in first episode psychosis. There is lack of studies distinguishing the predictive effects of different social ...
    • Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation 

      Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål; Boye, Birgitte; Bøen, Erlend; Drange, Ole Kristian; Elvsåshagen, Torbjørn; Engh, John; Hope, Sigrun; Høegh, Margrethe Collier; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Lekva, Tove; Malt, Ulrik Fredrik; Melle, Ingrid; Morken, Gunnar; Nærland, Terje; Steen, Vidar Martin; Sørensen, Kjetil; Wedervang-Resell, Kirsten; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2022)
      Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their ...
    • Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness 

      Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar Elle; Wedervang-Resell, Kirsten; Nerland, Stener; Westlye, Lars Tjelta; Nærland, Terje; Myhre, Anne Margrethe; Joa, Inge; Reitan, Solveig Merete Klæbo; Vaaler, Arne; Morken, Gunnar; Bøen, Erlend; Elvsåshagen, Torbjørn; Boye, Birgitte; Malt, Ulrik Fredrik; Aukrust, Pål; Skrede, Silje; Kroken, Rune Andreas; Johnsen, Erik; Djurovic, Srdjan; Andreassen, Ole; Ueland, Thor; Agartz, Ingrid (Journal article; Peer reviewed, 2021)
      Background: Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal ...
    • Obsessive-compulsive disorder (OCD) in patients with first- episode psychosis (FEP): A prospective study 

      Hagen, Kristen; Solem, Stian; Larsen, Tor Ketil; Joa, Inge; Kvale, Gerd; Hansen, Bjarne (Peer reviewed; Journal article, 2014)
    • One-year outcome and adherence to pharmacological guidelines in first-episode schizophrenia: Results from a consecutive cohort study 

      Drosos, Petros; Brønnick, Kolbjørn Kallesten; Joa, Inge; Johannessen, Jan Olav; Johnsen, Erik; Kroken, Rune Andreas; Stain, Helen J.; Hegelstad, Wenche; Larsen, Tor Ketil (Journal article; Peer reviewed, 2020)
      Background Remission in schizophrenia is difficult to achieve. Antipsychotic drugs are critical in the treatment of schizophrenia. International guidelines for the pharmacological treatment of schizophrenia recommend a ...
    • Psychotherapy in psychosis: Experiences of fully recovered service users 

      Bjørnestad, Jone Ravndal; Veseth, Marius; Davidson, Larry; Joa, Inge; Johannessen, Jan Olav; Larsen, Tor Ketil; Melle, Ingrid; Hegelstad, Wenche (Peer reviewed; Journal article, 2018-09-04)
      Background: Despite the evidence of the importance of including service users’ views on psychotherapy after psychosis, there is a paucity of research investigating impact on full recovery. Objectives: To explore what ...
    • Social media and social functioning in psychosis: A systematic review 

      Bjørnestad, Jone Ravndal; Hegelstad, Wenche; Berg, Henrik; Davidson, Larry; Joa, Inge; Johannessen, Jan Olav; Melle, Ingrid; Stain, Helen J.; Pallesen, Ståle (Peer reviewed; Journal article, 2019-06-21)
      Background: Individuals with psychosis are heavy consumers of social media. It is unknown to what degree measures of social functioning include measures of online social activity. Objective: To examine the inclusion of ...
    • Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation 

      Sheikh, Mashhood Ahmed; O'Connell, Kevin Sean; Lekva, Tove; Szabo, Attila; Akkouh, Ibrahim Ahmed; Osete, Jordi Requena; Agartz, Ingrid; Engh, John; Andreou, Dimitrios; Boye, Birgitte; Bøen, Erlend; Elvsåshagen, Torbjørn; Hope, Sigrun; Werner, Maren Caroline Frogner; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Melle, Ingrid; Drange, Ole Kristian; Morken, Gunnar; Nærland, Terje; Sørensen, Kjetil; Vaaler, Arne; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Aukrust, Pål; Djurovic, Srdjan; Steen, Nils Eiel; Andreassen, Ole; Ueland, Thor (Journal article; Peer reviewed, 2022)
      Background: Cell adhesion molecules (CAMs) orchestrate leukocyte trafficking and could link peripheral and neuroinflammation in patients with severe mental illness (SMI), by promoting inflammatory and immune-mediated ...
    • “We all have a responsibility”: a narrative discourse analysis of an information campaign targeting help-seeking in first episode psychosis 

      Hansen, Hege; Stige, Signe Hjelen; Moltu, Christian; Johannessen, Jan Olav; Joa, Inge; Dybvig, Sveinung; Veseth, Marius (Peer reviewed; Journal article, 2019-05-09)
      Background: Intervening at an early stage of psychosis improves the chances of recovery from first-episode psychosis. However, people who are experiencing distress and early psychotic symptoms generally seem to delay seeking ...