Browsing Bergen Open Research Archive by Author "Joa, Inge"
Now showing items 1-20 of 25
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Antidepressive Effectiveness of Amisulpride, Aripiprazole, and Olanzapine in Patients with Schizophrenia Spectrum Disorders: A Secondary Outcome Analysis of a Pragmatic, Randomized Trial (BeSt InTro)
Kjelby, Eirik; Gjestad, Rolf; Fathian, Farivar; Sinkeviciute, Igne; Alisauskiene, Renata; Anda, Liss; Løberg, Else-Marie; Reitan, Solveig Klæbo; Joa, Inge; Larsen, Tor Kjetil; Rettenbacher, Maria; Berle, Jan Øystein; Fasmer, Ole Bernt; Kroken, Rune Andreas; Johnsen, Erik (Journal article; Peer reviewed, 2023)Background Depressive symptoms are frequent in schizophrenia and associated with a poorer outcome. Currently, the optimal treatment for depressive symptoms in schizophrenia remains undetermined. Amisulpride, aripiprazole, ... -
Association between C-reactive protein levels and antipsychotic treatment during 12 months follow-up period after acute psychosis
Fathian, Farivar; Gjestad, Rolf; Kroken, Rune Andreas; Løberg, Else-Marie; Reitan, Solveig Merete Klæbo; Fleichhacker, W. Wolfgang; Rettenbacher, Maria; Larsen, Tor Ketil; Joa, Inge; Stabell, Lena Antonsen; Kjelby, Eirik; Sinkevicute, Igne; Alisauskiene, Renata; Steen, Vidar Martin; Johnsen, Erik (Journal article; Peer reviewed, 2022)Background A potential role of inflammatory pathways in the pathology of schizophrenia has been suggested for at least a subgroup of patients. Elevated levels of the inflammatory marker C-reactive protein (CRP) have been ... -
Association between cytokines and suicidality in patients with psychosis: A multicentre longitudinal analysis
Hoprekstad, Gunnhild Eldhuset; Skrede, Silje; Bartz-Johannessen, Christoffer; Joa, Inge; Reitan, Solveig Klæbo; Steen, Vidar Martin; Torsvik, Anja; Johnsen, Erik; Kroken, Rune Andreas; Rettenbacher, Maria (Journal article; Peer reviewed, 2024)Suicide is a common cause of death in all phases of schizophrenia spectrum disorder, particularly in the youngest patients. Clinical measures have demonstrated limited value in suicide prediction, spurring the search for ... -
Can systematic implementation support improve programme fdelity by improving care providers’ perceptions of implementation factors? A cluster randomized trial
Hartveit, Miriam; Hovlid, Einar; Øvretveit, John; Assmus, Jörg; Bond, Gary; Joa, Inge; Heiervang, Kristin Sverdvik; Stensrud, Bjørn; Høifødt, Tordis Sørensen; Biringer, Eva Aaker; Ruud, Torleif (Journal article; Peer reviewed, 2022)Background Investigations of implementation factors (e.g., collegial support and sense of coherence) are recommended to better understand and address inadequate implementation outcomes. Little is known about the relationship ... -
Cellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disorders
Gjerde, Kristian Varden; Bartz-Johannessen, Christoffer; Steen, Vidar Martin; Andreassen, Ole A.; Steen, Nils Eiel; Ueland, Thor; Lekva, Tove; Rettenbacher, Maria; Joa, Inge; Reitan, Solveig Klæbo; Johnsen, Erik; Kroken, Rune Andreas (Journal article; Peer reviewed, 2024)Background Endothelial inflammation may be involved in the pathogenesis of schizophrenia, and cellular adhesion molecules (CAMs) on endothelial cells may facilitate leukocyte binding and transendothelial migration of cells ... -
Childhood trauma types in relation to antipsychotic effectiveness in schizophrenia spectrum disorders: A prospective, pragmatic, randomized controlled study
Mørkved, Nina; Johnsen, Erik; Kroken, Rune Andreas; Joa, Inge; Kjelby, Eirik; Rettenbacher, M.A.; Bartz-Johannessen, Christoffer; Løberg, Else-Marie (Journal article; Peer reviewed, 2024)Treatment with antipsychotics (APs) for schizophrenia spectrum disorders (SSDs) is generally effective, however, a significant proportion does not respond favorably. Childhood trauma (CT) subtypes (physical, sexual, and ... -
Childhood trauma, antipsychotic medication, and symptom remission in first-episode psychosis
Ottesen, Akiah; Hegelstad, Wenche; Joa, Inge; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Røssberg, Jan Ivar; Simonsen, Erik; Johannessen, Jan Olav; Larsen, Tor Ketil; Haahr, Ulrik H.; McGlashan, T.H.; Friis, Svein; Melle, Ingrid (Journal article; Peer reviewed, 2021)Background: To what extent psychotic symptoms in first-episode psychosis (FEP) with a history of childhood interpersonal trauma (CIT) are less responsive to antipsychotic medication is not known. In this longitudinal study, ... -
Clinical insight among persons with schizophrenia spectrum disorders treated with amisulpride, aripiprazole or olanzapine: a semi-randomised trial
Stabell, Lena Antonsen; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Blindheim, Anne Alnes; Joa, Inge; Reitan, Solveig Klæbo; Rettenbacher, M.; Munk-Jørgensen, P.; Gjestad, Rolf (Journal article; Peer reviewed, 2023)Background Antipsychotic treatment may improve clinical insight. However, previous studies have reported inconclusive findings on whether antipsychotics improve insight over and above the reduction in symptoms of ... -
Cognitive change and antipsychotic medications: Results from a pragmatic rater-blind RCT
Anda, Liss; Johnsen, Erik; Kroken, Rune A.; Joa, Inge; Rettenbacher, Maria; Løberg, Else-Marie (Journal article; Peer reviewed, 2021)Cognitive impairment is a core aspect of psychotic disorders and difficult to treat. Atypical antipsychotics (AAs) might have differential effects on cognitive impairment, but rigid study designs and selective sampling ... -
Cognitive profile in ultra high risk for psychosis and schizophrenia: A comparison using coordinated norms
Anda-Ågotnes, Liss Gøril; Brønnick, Kolbjørn Kallesten; Johannessen, Jan Olav; Joa, Inge; Kroken, Rune Andreas; Johnsen, Erik; Rettenbacher, Maria; Fathian, Farivar; Løberg, Else-Marie (Peer reviewed; Journal article, 2019-10-01)Background: Cognitive impairment is not only a core aspect of schizophrenia but also commonly observed in help-seeking youth at ultra high risk for psychosis (UHR), with potential implications for prognosis and individualized ... -
Differential Effectiveness of Atypical Antipsychotics on Hallucinations: A Pragmatic Randomized Controlled Trial
Sinkeviciute, Igne; Hugdahl, Kenneth Jan; Bartz-Johannessen, Christoffer; Kroken, Rune Andreas; Løberg, Else-Marie; Kjelby, Eirik; Rettenbacher, maria; Joa, Inge; Reitan, Solveig Merete Klæbo; Alisauskiene, Renata; Fathian, Farivar; Johnsen, Erik (Journal article; Peer reviewed, 2021-07)Background Most studies investigating antipsychotic effectiveness report either total psychopathology or symptom cluster findings. Studies focusing on a separate symptom, such as hallucinations, a hallmark symptom in ... -
Does drug use affect the efficacy of amisulpride, aripiprazole and olanzapine in patients with schizophrenia spectrum disorders? Results from a pragmatic, randomised study
Alisauskiene, Renata; Johnsen, Erik; Gjestad, Rolf; Kroken, Rune Andreas; Kjelby, Eirik; Sinkeviciute, Igne; Fathian, Farivar; Joa, Inge; Reitan, Solveig Klæbo; Rettenbacher, Maria; Løberg, Else-Marie (Journal article; Peer reviewed, 2023)Objectives Drug use is prevalent in patients with schizophrenia spectrum disorders (SSD) but there is limited knowledge about the influence of drug use on the effectiveness of antipsychotic medication. This secondary ... -
Early substance use cessation improves cognition-10 years outcome in first-episode psychosis patients
Weibell, Melissa Anne E; Johannessen, Jan Olav; Auestad, Bjørn Henrik; Bramness, Jørgen Gustav; Brønnick, Kolbjørn Kallesten; Haahr, Ulrik; Joa, Inge; Larsen, Tor Ketil; Melle, Ingrid; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Røssberg, Jan Ivar; Simonsen, Erik; Vaglum, Per; Stain, Helen J.; Friis, Svein; Hegelstad, Wenche (Peer reviewed; Journal article, 2019-07-12)Background: Cognitive impairment may be a risk factor for, as well as a consequence of, psychosis. Non-remitting symptoms, premorbid functioning, level of education, and socioeconomic background are known correlates. A ... -
The Effect of Intensive Implementation Support on Fidelity for Four Evidence‑Based Psychosis Treatments: A Cluster Randomized Trial
Ruud, Torleif; Drake, Robert E.; Saltyte Benth, Jurate; Drivenes, Karin; Hartveit, Miriam; Heiervang, Kristin Sverdvik; Høifødt, Tordis Sørensen; Haaland, Vegard Øksendal; Joa, Inge; Johannessen, Jan Olav; Johansen, Karl Johan; Stensrud, Bjørn; Haugom, Espen Woldsengen; Clausen, Hanne Kristin; Biringer, Eva Aaker; Bond, Gary R. (Journal article; Peer reviewed, 2021)Purpose Service providers need effective strategies to implement evidence-based practices (EBPs) with high fidelity. This study aimed to evaluate an intensive implementation support strategy to increase fidelity to EBP ... -
"Everyone Needs a Friend Sometimes" - social predictors of long-term remission in first episode psychosis
Bjørnestad, Jone Ravndal; Joa, Inge; Larsen, Tor Ketil; Langeveld, Johannes H.; Davidson, Larry; Hegelstad, Wenche; Anda-Ågotnes, Liss Gøril; Veseth, Marius; Melle, Ingrid; Johannessen, Jan Olav; Brønnick, Kolbjørn Selvåg (Peer reviewed; Journal article, 2016-10-04)Background: Predictors of long-term symptomatic remission are crucial to the successful tailoring of treatment in first episode psychosis. There is lack of studies distinguishing the predictive effects of different social ... -
Implementing Clinical Guidelines for the Treatment of Psychosis: The Frontline Leaders’ Point of View. A Qualitative Study
Nordin, Håkan; Mathisen, Gro Ellen; Rørtveit, Kristine; Joa, Inge; Johannessen, Jan Olav; Ruud, Torleif; Hartveit, Miriam (Journal article; Peer reviewed, 2024)Background: Despite the large amount of leadership and implementation theories and recommendations, healthcare services continue to struggle with efficiently incorporating new knowledge. The questioning of conventional ... -
Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation
Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål; Boye, Birgitte; Bøen, Erlend; Drange, Ole Kristian; Elvsåshagen, Torbjørn; Engh, John; Hope, Sigrun; Høegh, Margrethe Collier; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Lekva, Tove; Malt, Ulrik Fredrik; Melle, Ingrid; Morken, Gunnar; Nærland, Terje; Steen, Vidar Martin; Sørensen, Kjetil; Wedervang-Resell, Kirsten; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2022)Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their ... -
Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness
Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar Elle; Wedervang-Resell, Kirsten; Nerland, Stener; Westlye, Lars Tjelta; Nærland, Terje; Myhre, Anne Margrethe; Joa, Inge; Reitan, Solveig Merete Klæbo; Vaaler, Arne; Morken, Gunnar; Bøen, Erlend; Elvsåshagen, Torbjørn; Boye, Birgitte; Malt, Ulrik Fredrik; Aukrust, Pål; Skrede, Silje; Kroken, Rune Andreas; Johnsen, Erik; Djurovic, Srdjan; Andreassen, Ole; Ueland, Thor; Agartz, Ingrid (Journal article; Peer reviewed, 2021)Background: Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal ... -
Obsessive-compulsive disorder (OCD) in patients with first- episode psychosis (FEP): A prospective study
Hagen, Kristen; Solem, Stian; Larsen, Tor Ketil; Joa, Inge; Kvale, Gerd; Hansen, Bjarne (Peer reviewed; Journal article, 2014) -
One-year outcome and adherence to pharmacological guidelines in first-episode schizophrenia: Results from a consecutive cohort study
Drosos, Petros; Brønnick, Kolbjørn Kallesten; Joa, Inge; Johannessen, Jan Olav; Johnsen, Erik; Kroken, Rune Andreas; Stain, Helen J.; Hegelstad, Wenche; Larsen, Tor Ketil (Journal article; Peer reviewed, 2020)Background: Remission in schizophrenia is difficult to achieve. Antipsychotic drugs are critical in the treatment of schizophrenia. International guidelines for the pharmacological treatment of schizophrenia recommend a ...