Blar i Bergen Open Research Archive på forfatter "Johannessen, Tor-Christian Aase"
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Glioblastom hos voksne
Schipmann, Stephanie; Sivakanesan, Sarankan; Rath, Daniel Stavne; Brandal, Petter; Vik-Mo, Einar Osland; Bjørås, Magnar; Solheim, Ole Skeidsvoll; Ingebrigtsen, Tor; Sund, Fredrik; Bjerkvig, Rolf; Miletic, Hrvoje; Johannessen, Tor-Christian Aase; Sundstrøm, Terje (Journal article; Peer reviewed, 2023)Glioblastom er den vanligste formen for primær hjernekreft hos voksne, og sykdommen har en alvorlig prognose. Selv om det er gjort store fremskritt i molekylær karakteristikk, har det ikke vært større gjennombrudd i ... -
Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity
Ohba, Shigeo; Johannessen, Tor-Christian Aase; Chatla, Kamalakar; Yang, Xiaodong; Pieper, Russell O.; Mukherjee, Joydeep (Journal article; Peer reviewed, 2020)The metabolic enzyme phosphoglycerate mutase 1 (PGAM1) is overexpressed in several types of cancer, suggesting an additional function beyond its established role in the glycolytic pathway. We here report that PGAM1 is ... -
PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas
Ohba, Shigeo; Tang, Yongjian; Johannessen, Tor-Christian Aase; Mukherjee, Joydeep (Journal article; Peer reviewed, 2022)PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, ...