Browsing Bergen Open Research Archive by Author "Johnston, Iain George"
Now showing items 1-8 of 8
-
Data-Driven Inference Reveals Distinct and Conserved Dynamic Pathways of Tool Use Emergence across Animal Taxa
Johnston, Iain George; Røyrvik, Ellen Christine (Journal article; Peer reviewed, 2020)Tool use is a striking aspect of animal behavior, but it is hard to infer how the capacity for different types of tool use emerged across animal taxa. Here we address this question with HyperTraPS, a statistical approach ... -
Efficient vasculature investment in tissues can be determined without global information
Johnston, Iain George; Bassel, George (Journal article; Peer reviewed, 2020)Cells are the fundamental building blocks of organs and tissues. Information and mass flow through cellular contacts in these structures is vital for the orchestration of organ function. Constraints imposed by packing and ... -
Evolving mtDNA populations within cells
Johnston, Iain George; Burgstaller, Joerg (Peer reviewed; Journal article, 2019)Mitochondrial DNA (mtDNA) encodes vital respiratory machinery. Populations of mtDNA molecules exist in most eukaryotic cells, subject to replication, degradation, mutation, and other population processes. These processes ... -
Mitochondrial network state scales mtDNA genetic dynamics
Aryaman, Juvid; Bowles, Charlotte; Jones, Nick; Johnston, Iain George (Peer reviewed; Journal article, 2019)Mitochondrial DNA (mtDNA) mutations cause severe congenital diseases but may also be associated with healthy aging. mtDNA is stochastically replicated and degraded, and exists within organelles which undergo dynamic fusion ... -
Model selection and parameter estimation for root architecture models using likelihood-free inference
Ziegler, Clare; Dyson, Rosemary; Johnston, Iain George (Peer reviewed; Journal article, 2019)Plant root systems play vital roles in the biosphere, environment and agriculture, but the quantitative principles governing their growth and architecture remain poorly understood. The ‘forward problem’ of what root forms ... -
Precision identification of high-risk phenotypes and progression pathways in severe malaria without requiring longitudinal data
Johnston, Iain George; Hoffmann, Till; Greenbury, Sam; Cominetti, Ornella; Jallow, Muminatou; Kwiatkowski, Dominic; Barahona, Mauricio; Jones, Nick; Casals-Pascual, Climent (Peer reviewed; Journal article, 2019)More than 400,000 deaths from severe malaria (SM) are reported every year, mainly in African children. The diversity of clinical presentations associated with SM indicates important differences in disease pathogenesis that ... -
Understanding learner behaviour in online courses with Bayesian modelling and time series characterisation
Johnston, Iain George; Greenbury, Sam; Peach, Robert; yaliraki, sophia; Lefèvre, David; Barahona, Mauricio (Journal article; Peer reviewed, 2021)The intrinsic temporality of learning demands the adoption of methodologies capable of exploiting time-series information. In this study we leverage the sequence data framework and show how data-driven analysis of temporal ... -
Varied mechanisms and models for the varying mitochondrial bottleneck
Johnston, Iain George (Peer reviewed; Journal article, 2019-11-20)Mitochondrial DNA (mtDNA) molecules exist in populations within cells, and may carry mutations. Different cells within an organism, and organisms within a family, may have different proportions of mutant mtDNA in these ...