Blar i Bergen Open Research Archive på forfatter "Jonsson, Roland"

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    • Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation 

      Sarkar, Irene; Davies, Richard Allan; Aarebrot, Anders Krogh; Solberg, Silje Michelsen; Petrovic, Aleksandra; Joshi, Anagha; Bergum, Brith; Brun, Johan Gorgas; Hammenfors, Daniel; Jonsson, Roland; Appel, Silke (Journal article; Peer reviewed, 2022)
      Background: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, characterized by mononuclear cell infiltrates in the salivary and lacrimal glands, leading to glandular atrophy and dryness. Patient heterogeneity ...

    • Addressing the clinical unmet needs in primary Sjögren's Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts 

      Pezoulas, Vasileios C.; Goules, Andreas; Kalatzis, Fanis; Chatzis, Luke; Kourou, Konstantina D.; Venetsanopoulou, Aliki; Exarchos, Themis P.; Gandolfo, Saviana; Votis, Konstantinos; Zampeli, Evi; Burmeister, Jan; May, Thorsten; Marcelino Pérez, Manuel; Lishchuk, Iryna; Chondrogiannis, Thymios; Andronikou, Vassiliki; Varvarigou, Theodora; Filipovic, Nenad; Tsiknakis, Manolis; Baldini, Chiara; Bombardieri, Michele; Bootsma, Hendrika; Bowman, Simon J.; Shahnawaz Soyfoo, Muhammad; Parisis, Dorian; Delporte, Christine; Devauchelle-Pensec, Valérie; Pers, Jacques-Olivier; Dörner, Thomas; Bartoloni, Elena; Gerli, Roberto; Giacomelli, Roberto; Jonsson, Roland; Ng, Wan-Fai; Priori, Roberta; Ramos-Casals, Manuel; Sivils, Kathy; Skopouli, Fotini; Torsten, Witte; A. G. van Roon, Joel; Xavier, Mariette; De Vita, Salvatore; Tzioufas, Athanasios G.; Fotiadis, Dimitrios I. (Journal article; Peer reviewed, 2022)
      For many decades, the clinical unmet needs of primary Sjögren’s Syndrome (pSS) have been left unresolved due to the rareness of the disease and the complexity of the underlying pathogenic mechanisms, including the ...

    • Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome 

      Vogelsang, Petra; Karlsen, Marie; Brun, Johan Gorgas; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2014-08-11)
      Introduction: Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system, involved in both initiating immune responses and maintaining tolerance. Dysfunctional and via toll-like receptor (TLR) ...

    • The Bacterial Preparation OK432 Induces IL-12p70 Secretion in Human Dendritic Cells in a TLR3 Dependent Manner 

      Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2012-02-21)
      Dendritic cells (DC) used in therapeutic cancer immunotherapy have to be able to stimulate T cells resulting in an immune response that can efficiently target the cancer cells. One of the critical hurdles has been the lack ...

    • Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations 

      Delaleu, Nicolas Hervé; Immervoll, Heike; Cornelius, Janet; Jonsson, Roland (Peer reviewed; Journal article, 2008-02-20)
      Introduction Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly targets the exocrine glands. The aim of this study was to investigate the involvement of 87 proteins measured in serum and 75 proteins ...

    • Biomarkers of inflammation and left ventricular remodelling in psoriasis patients treated with infliximab 

      Midtbø, Helga Bergljot; Kringeland, Ester Anne; Gerdts, Eva; Ueland, Per Magne; Meyer, Klaus; Linde, Anja G; Ulvik, Arve; Jonsson, Roland; Tveit, Kåre Steinar (Journal article; Peer reviewed, 2022)
      Objective: Psoriasis is an immune mediated disorder associated with T cell activation and cardiovascular disease (CVD). We explored the association of inflammation with left ventricular (LV) remodelling in psoriasis patients ...

    • Carbamylation of immunoglobulin abrogates activation of the classical complement pathway 

      Koro, Catalin; Bielecka, Ewa; Dahl-Knudsen, Anders; Enghild, Jan J; Scavenius, Carsten; Brun, Johan G; Binder, Veronika; Hellvard, Annelie; Bergum, Brith; Jonsson, Roland; Potempa, Jan; Blom, Anna M.; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2014-11)
      Post-translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory ...

    • Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases 

      Lundtoft, Christian; Pucholt, Pascal; Martin, Myriam; Bianchi, Matteo; Lundström, Emeli; Eloranta, Maija-Leena; Sandling, Johanna K.; Sjöwall, Christopher; Jönsen, Andreas; Gunnarsson, Iva; Rantapää-Dahlqvist, Solbritt; Bengtsson, Anders A.; Leonard, Dag; Baecklund, Eva; Jonsson, Roland; Hammenfors, Daniel; Forsblad-d'Elia, Helena; Eriksson, Per; Mandl, Thomas; Magnusson Bucher, Sara; Norheim, Katrine Brække; Johnsen, Svein Joar Auglæn; Omdal, Roald; Kvarnström, Marika; Wahren Herlenius, Marie Elisabeth; Notarnicola, Antonella; Andersson, Anna Helena; Molberg, Øyvind; Diederichsen, Louise Pyndt; Almlöf, Jonas; Syvänen, Ann-Christine; Kozyrev, Sergey V.; Lindblad-Toh, Kerstin; Rönnblom, Lars; Brokstad, Karl Albert; Skarstein, Kathrine; Jonsson, Malin Viktoria; Appel, Silke; Aqrawi, Lara A.; Jensen, Janicke Liaaen; Palm, Øyvind; Nilsson, Birgitta Blakstad; Blom, Anna M.; Lundberg, Ingrid E.; Nordmark, Gunnel; Diaz-Gallo, Lina Marcela; Svenungsson, Elisabet; Rönnblom, Lars (Journal article; Peer reviewed, 2022)
      Objective Copy number variation of the C4 complement components, C4A and C4B, has been associated with systemic inflammatory autoimmune diseases. This study was undertaken to investigate whether C4 copy number variation ...

    • Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome 

      Karlsen, Marie; Hansen, Torbjørn; Nordal, Hilde Haugedal; Brun, Johan G; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2015-03-19)
      Introduction: Sjögren’s syndrome (SS) is a rheumatic autoimmune disease characterized by inflammation of exocrine glands. As autoantibodies are present in a majority of patients, B cells have been suggested to play an ...

    • A five-year prospective study of fatigue in primary Sjögren’s syndrome 

      Haldorsen, Karstein; Bjelland, Ingvar; Bolstad, Anne Isine; Jonsson, Roland; Brun, Johan Gorgas (Peer reviewed; Journal article, 2011-10-13)
      Introduction: Fatigue is prevalent in primary Sjögren’s syndrome (pSS), and contributes to the considerably reduced health related quality of life in this disease. The symptom is included in proposed disease activity and ...

    • Genetic variants at the RTP4/MASP1 locus are associated with fatigue in Scandinavian patients with primary Sjögren’s syndrome 

      Norheim, Katrine Brække; Imgenberg-Kreuz, Juliana; Alexsson, Andrei; Johnsen, Svein Joar Auglæn; Bårdsen, Kjetil; Brun, Johan Gorgas; Dehkordi, Rezvan Kiani; Theander, Elke; Mandl, Thomas; Jonsson, Roland; Ng, Wan-Fai; Lessard, Christopher J; Rasmussen, Astrid; Sivilis, Kathy; Rönnblom, Lars; Omdal, Roald (Journal article; Peer reviewed, 2021)
      Objectives Fatigue is common and severe in primary Sjögren’s syndrome (pSS). The aim of this study was to identify genetic determinants of fatigue in pSS through a genome-wide association study. Methods Patients with ...

    • Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells 

      Khatri, Bhuwan; Tessneer, Kandice L.; Rasmussen, Astrid; Aghakhanian, Farhang; Reksten, Tove Ragna; Adler, Adam; Alevizos, Ilias; Anaya, Juan-Manuel; Aqrawi, Lara A.; Baecklund, Eva; Brun, Johan Gorgas; Bucher, Sara Magnusson; Eloranta, Maija-Leena; Engelke, Fiona; Forsblad-d’Elia, Helena; Glenn, Stuart B.; Hammenfors, Daniel; Imgenberg-Kreuz, Juliana; Jensen, Janicke Liaaen; Johnsen, Svein Joar Auglæn; Jonsson, Malin Viktoria; Kvarnström, Marika; Kelly, Jennifer A.; Li, He; Mandl, Thomas; Martín, Javier; Nocturne, Gaétane; Norheim, Katrine Brække; Palm, Øyvind; Skarstein, Kathrine; Stolarczyk, Anna M.; Taylor, Kimberly E.; Teruel, Maria; Theander, Elke; Venuturupalli, Swamy; Wallace, Daniel J.; Grundahl, Kiely M.; Hefner, Kimberly S.; Radfar, Lida; Lewis, David M.; Stone, Donald U.; Kaufman, C. Erick; Brennan, Michael T.; Guthridge, Joel M.; James, Judith A.; Scofield, R. Hal; Gaffney, Patrick M.; Criswell, Lindsey A.; Jonsson, Roland; Eriksson, Per; Bowman, Simon J.; Omdal, Roald; Rönnblom, Lars; Warner, Blake; Rischmueller, Maureen; Witte, Torsten; Farris, A. Darise; Mariette, Xavier; Alarcon-Riquelme, Marta E.; Shiboski, Caroline H.; Herlenius, Marie Elisabeth Wahren; Ng, Wan-Fai; Sivils, Kathy L.; Adrianto, Indra; Nordmark, Gunnel; Lessard, Christopher J. (Journal article; Peer reviewed, 2022)
      Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s cases of ...

    • Identification and functional characterization of a novel susceptibility locus for small vessel vasculitis with MPO-ANCA 

      Dahlqvist, Johanna; Ekman, Diana; Sennblad, Bengt; Kozyrev, Sergey V.; Nordin, Jessika; Karlsson, Åsa; Meadows, Jennifer R. S.; Hellbacher, Erik; Rantapää-Dahlqvist, Solbritt; Berglin, Ewa; Stegmayr, Bernd; Haslund, Bo; Palm, Øyvind; Haukeland, Hilde; Gunnarsson, Iva; Bruchfeld, Annette; Segelmark, Mårten; Ohlsson, Sophie; Mohammad, Aladdin J.; Svärd, Anna Jessica; Pullerits, Rille; Herlitz, Hans; Söderbergh, Annika; Pielberg, Gerli Rosengren; Rosenberg, Lina Hultin; Bianchi, Matteo; Muren, Eva; Omdal, Roald; Jonsson, Roland; Eloranta, Maija-Leena; Rönnblom, Lars; Söderkvist, Peter; Knight, Ann; Eriksson, Per; Lindblad-Toh, Kerstin (Journal article; Peer reviewed, 2021)
      Objective To identify and characterize genetic loci associated with the risk of developing ANCA-associated vasculitides (AAV). Methods Genetic association analyses were performed after Illumina sequencing of 1853 genes ...

    • Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome 

      Keindl, Magdalena; Davies, Richard Allan; Bergum, Brith; Brun, Johan Gorgas; Hammenfors, Daniel; Jonsson, Roland; Lyssenko, Valeriya; Appel, Silke (Journal article; Peer reviewed, 2022)
      Background Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune diseases. ...

    • In Situ Expression of Cytokines and Cellular Phenotypes in the Lungs of Mice with Slowly Progressive Primary Tuberculosis 

      Mustafa, Tehmina; Phyu, S.; Nilsen, Rune; Jonsson, Roland; Bjune, Gunnar Aksel (Peer reviewed; Journal article, 2000-06)
      The cellular phenotypes and the expression of cytokines were studied in the lungs of mice, using immunohistochemistry, during different phases of slowly progressive primary murine tuberculosis infection. During the first ...

    • In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome 

      Volchenkov, Roman; Brun, Johan Gorgas; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2013-09-09)
      Introduction: Therapeutic vaccination with antigen-specific tolerogenic dendritic cells (tolDC) might become a future option of individualized therapy for patients with autoimmune diseases. In this study, we tested the ...

    • Increased Expression of Fas Ligand in Human Tuberculosis and Leprosy Lesions: a Potential Novel Mechanism of Immune Evasion in Mycobacterial Infection 

      Mustafa, Tehmina; Bjune, Gunnar Aksel; Jonsson, Roland; Pando, R. Hernandez; Nilsen, Rune (Peer reviewed; Journal article, 2001-12)
      To study the location and mechanism of apoptosis within the human tuberculosis (TB) and leprosy lesions, parallel sections were analyzed for mycobacterial antigens (M.Ag), Fas ligand (FasL), Fas, CD68 and Mac387 by ...

    • Inflammatory Stratification in Primary Sjögren’s Syndrome Reveals Novel Immune Cell Alterations in Patients’ Minor Salivary Glands 

      Bharaj, Tamandeep Kaur; Aqrawi, Lara A.; Fromreide, Siren; Jonsson, Roland; Brun, Johan G.; Appel, Silke; Skarstein, Kathrine (Journal article; Peer reviewed, 2021)
      There is a critical need to deconvolute the heterogeneity displayed by the minor salivary glands of primary Sjögren’s syndrome (pSS) patients. This is challenging primarily because the disease etiology remains unknown. The ...

    • The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice 

      Hjelmervik, Trond Ove R.; Linqvist, Anne-Karin; Petersen, Kjell; Johannesson, Martina; Stavrum, Anne-Kristin; Johansson, Åsa; Jonsson, Roland; Holmdahl, Rikard; Bolstad, Anne Isine (Peer reviewed; Journal article, 2007-09-27)
      The nonobese diabetic (NOD) Nss1 and Idd5 loci have been associated with sialadenitis development in mice. In this study the NOD Nss1 and Idd5 loci were backcrossed onto the healthy control strain B10.Q by using the speed ...

    • Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses 

      Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Aarstad, Hans Jørgen; Appel, Silke (Peer reviewed; Journal article, 2011-01-05)
      Background: Design of tumour specific immunotherapies using the patients’ own dendritic cells (DC) is a fast advancing scientific field. The functional qualities of the DC generated in vitro are critical, and today’s gold ...