Blar i Bergen Open Research Archive på forfatter "Karlsen, Odd André"
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The chemical defensome of five model teleost fish
Eide, Marta; Zhang, Xiaokang; Karlsen, Odd André; Goldstone, Jared V.; Stegeman, John; Jonassen, Inge; Goksøyr, Anders (Journal article; Peer reviewed, 2021)How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and ... -
Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics
Yadetie, Fekadu; Butcher, Stephen; Førde, Hilde E.; Campsteijn, Coen; Bouquet, Jean-Marie; Karlsen, Odd André; Denoeud, France; Metpally, Raghu; Thompson, Eric M.; Manak, J. Robert; Goksøyr, Anders; Chourrout, Daniel (Peer reviewed; Journal article, 2012-02-02)Background Animals have developed extensive mechanisms of response to xenobiotic chemical attacks. Although recent genome surveys have suggested a broad conservation of the chemical defensome across metazoans, global gene ... -
Contaminant accumulation and biological responses in Atlantic cod (Gadus morhua) caged at a capped waste disposal site in Kollevåg, Western Norway
Dale, Karina; Müller, Mette Bjørge; Tairova, Zhanna; Khan, Essa Ahsan; Hatlen, Kristin; Grung, Merete; Yadetie, Fekadu; Lille-Langøy, Roger; Blaser, Nello; Skaug, Hans J; Lyche, Jan Ludvig; Arukwe, Augustine; Hylland, Ketil; Karlsen, Odd André; Goksøyr, Anders (Peer reviewed; Journal article, 2019)The aim of this study was to assess whether fish in Kollevåg, a sheltered bay on the western coast of Norway, previously utilized as a waste disposal site, could be affected by environmental contaminants leaking from the ... -
CorA is a copper repressible surface-associated copper(I)-binding protein produced in Methylomicrobium album BG8
Johnson, Kenneth; Ve, Thomas; Larsen, Øivind; Pedersen, Rolf B.; Lillehaug, Johan R.; Jensen, Harald B.; Helland, Ronny; Karlsen, Odd André (Peer reviewed; Journal article, 2014-02-03)CorA is a copper repressible protein previously identified in the methanotrophic bacterium Methylomicrobium album BG8. In this work, we demonstrate that CorA is located on the cell surface and binds one copper ion per ... -
Introducing active learning strategies in toxicology teaching
Karlsen, Odd André (UPED-skrift, Working paper, 2017-10) -
Liver transcriptome analysis of Atlantic cod (Gadus morhua) exposed to PCB 153 indicates effects on cell cycle regulation and lipid metabolism
Yadetie, Fekadu; Karlsen, Odd André; Eide, Marta; Hogstrand, Christer; Goksøyr, Anders (Peer reviewed; Journal article, 2014-06-17)Background: Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) with harmful effects in animals and humans. Although PCB 153 is one of the most abundant among PCBs detected in animal tissues, its ... -
The Methylococcus capsulatus (Bath) Secreted Protein, MopE*, Binds Both Reduced and Oxidized Copper
Ve, Thomas; Mathisen, Karina; Helland, Ronny; Karlsen, Odd André; Fjellbirkeland, Anne; Røhr, Åsmund K.; Andersson, K. Kristoffer; Pedersen, Rolf Birger; Lillehaug, Johan; Jensen, Harald B. (Peer reviewed; Journal article, 2012-08-20)Under copper limiting growth conditions the methanotrophic bacterium Methylococcus capsulatus (Bath) secrets essentially only one protein, MopE*, to the medium. MopE* is a copper-binding protein whose structure has been ... -
Polycyclic aromatic hydrocarbons modulate the activity of Atlantic cod (Gadus morhua) vitamin D receptor paralogs in vitro
Goksøyr, Siri Øfsthus; Goldstone, Jed; Lille-Langøy, Roger; Lock, Erik Jan Robert; Olsvik, Pål Asgeir; Goksøyr, Anders; Karlsen, Odd André (Journal article; Peer reviewed, 2021)Vitamin D receptor (VDR) mediates the biological function of the steroid hormone calcitriol, which is the metabolically active version of vitamin D. Calcitriol is important for a wide array of physiological functions, ... -
Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism
Yadetie, Fekadu; Bjørneklett, Silje; Garberg, Hilde K; Oveland, Eystein; Berven, Frode; Goksøyr, Anders; Karlsen, Odd André (Peer reviewed; Journal article, 2016-08-05)Background: Methylmecury (MeHg) is a widely distributed environmental pollutant with considerable risk to both human health and wildlife. To gain better insight into the underlying mechanisms of MeHg-mediated toxicity, we ... -
Substituted Two- To Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a
Lille-Langøy, Roger; Jørgensen, Kåre Bredeli; Goksøyr, Anders; Pampanin, Daniela Maria; Sydnes, Magne Olav; Karlsen, Odd André (Journal article; Peer reviewed, 2021)Polycyclic aromatic hydrocarbons (PAHs) are among the most toxic and bioavailable components found in petroleum and represent a high risk to aquatic organisms. The aryl hydrocarbon receptor (Ahr) is a ligand-activated ... -
Toxicity assessment of urban marine sediments from Western Norway using a battery of stress-activated receptors and cell-based bioassays from fish
Goksøyr, Siri Øfsthus; Sørensen, Helene; Grøsvik, Bjørn Einar; Pampanin, Daniela Maria; Goksøyr, Anders; Karlsen, Odd André (Journal article; Peer reviewed, 2021)A luciferase reporter gene-based bioassay battery consisting of stress-activated receptors from fish, complemented with traditional fish cell-based bioassays, were used to assess the toxicity of marine sediment samples ... -
Transcriptome responses in polar cod (Boreogadus saida) liver slice culture exposed to benzo[a]pyrene and ethynylestradiol: insights into anti-estrogenic effects
Yadetie, Fekadu; Brun, Nadja R; Vieweg, Ireen; Nahrgang, Jasmine; Karlsen, Odd André; Goksøyr, Anders (Journal article; Peer reviewed, 2021)Polar cod (Boreogadus saida) is a key species in the arctic marine ecosystem vulnerable to effects of pollution, particularly from petroleum related activities. To facilitate studying the effects of those pollutants, we ... -
Transcriptomic profiling of Methylococcus capsulatus (Bath)during growth with two different methane monooxygenases
Larsen, Øivind; Karlsen, Odd André (Peer reviewed; Journal article, 2016-04)Methylococcus capsulatus (Bath) is a methanotroph that possesses both a membrane-embedded (pMMO) and a soluble methane monooxygenase (sMMO). The expression of these two MMO's is tightly controlled by the availability of ... -
Xenobiotic metabolism and its physiological consequences in high‑Antarctic Notothenioid fishes
Strobel, Anneli; Lille-Langøy, Roger; Segner, Helmut; Burkhardt-Holm, Patricia; Goksøyr, Anders; Karlsen, Odd André (Journal article; Peer reviewed, 2022)The Antarctic ecosystem is progressively exposed to anthropogenic contaminants, such as polycyclic aromatic hydrocarbons (PAHs). So far, it is largely unknown if PAHs leave a mark in the physiology of high-Antarctic fish. ...