Blar i Bergen Open Research Archive på forfatter "Kehrein, Josef"
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Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97
Bothe, Sebastian; Hänzelmann, Petra; Böhler, Stephan; Kehrein, Josef; Zehe, Markus; Wiedemann, Christoph; Hellmich, Ute A.; Brenk, Ruth; Schindelin, Hermann; Sotriffer, Christoph (Journal article; Peer reviewed, 2022)Biosensor techniques have become increasingly important for fragment-based drug discovery during the last years. The AAA+ ATPase p97 is an essential protein with key roles in protein homeostasis and a possible target for ... -
How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System
Kersten, Christian; Fleischer, Edmond; Kehrein, Josef; Borek, Christoph; Jaenicke, Elmar; Sotriffer, Christoph; Brenk, Ruth (Peer reviewed; Journal article, 2020)A model system of two related enzymes with conserved binding sites, namely N-myristoyltransferase from two different organisms, was studied to decipher the driving forces that lead to selective inhibition in such cases. ...