• Differences in mortality in critically ill elderly patients during the second COVID‑19 surge in Europe 

      Jung, Christian; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolf, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Miroslaw; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Andersen, Finn H.; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans (Journal article; Peer reviewed, 2021)
      Background: The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. Methods: This was a prospective European ...
    • Disease-Course Adapting Machine Learning Prognostication Models in Elderly Patients Critically Ill With COVID-19: Multicenter Cohort Study With External Validation 

      Jung, Christian; Mamandipoor, Behrooz; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter V.; Szczeklik, Wojciech; Czuczwar, Miroslaw; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian; Osmani, Venet (Journal article; Peer reviewed, 2022)
      Background:The COVID-19 pandemic caused by SARS-CoV-2 is challenging health care systems globally. The disease disproportionately affects the elderly population, both in terms of disease severity and mortality risk. ...
    • The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study 

      Jung, Christian; Flaatten, Hans; Fjølner, Jesper; Romano Bruno, Raphael; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Miroslaw; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand (Journal article; Peer reviewed, 2021)
      Background The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in ...
    • Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients 

      Bruno, Raphael Romano; Wernley, Bernhard; Flaatten, Hans; Fjølner, Jesper; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Binnebössel, Stephan; Baldia, Philipp Heinrich; Kelm, Malte; Beil, Michael; Sigal, Sivri; van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Wollborn, Jakob; Banzo, Maria José Arche; Fuest, Kristina; Marsh, Brian; Andersen, Finn H.; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Jung, Christian (Journal article; Peer reviewed, 2021)
      Purpose: Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who have ...
    • Management and outcomes in critically ill nonagenarian versus octogenarian patients 

      Bruno, Raphael Romano; Wernly, Bernhard; Kelm, Malte; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn H.; Artigas, Antonio; Finazzi, Stefano; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Lichtenauer, Michael; Flaatten, Hans; Jung, Christian (Journal article; Peer reviewed, 2021)
      Background: Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. ...
    • Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis 

      Wernly, Bernhard; Bruno, Raphael Romano; Kelm, Malte; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn Husøy; Artigas, Antonio; Finazzi, Stefano; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Lichtenauer, Michael; Muessig, Johanna M.; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Öhman, Christina Agwald; Pinto, Bernadro Bollen; Soliman, Ivo W.; Szczeklik, Wojciech; Niederseer, David; Valentin, Andreas; Watson, Ximena; Leaver, Susannah; Boulanger, Carole; Walther, Sten; Schefold, Jörg C.; Joannidis, Michael; Nalapko, Yuriy; Elhadi, Muhammed; Fjølner, Jesper; Zafeiridis, Tilemachos; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans; Jung, Christian (Journal article; Peer reviewed, 2020)
      Female and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and ...
    • Steroid use in elderly critically ill COVID-19 patients 

      Jung, Christian; Wernly, Bernhard; Fjølner, Jesper; Bruno, Raphael Romano; Dudzinski, David; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Jörg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sigal, Sviri; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Mirosław; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian (Journal article; Peer reviewed, 2021)
      This secondary analysis of the COVIP study shows a higher 30-day mortality in critically ill elderly COVID-19 patients who received steroids as part of their treatment