Browsing Bergen Open Research Archive by Author "Khorsand, Fahimeh"
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Expression and purification of human neutrophil proteinase 3 from insect cells and characterization of ligand binding
Khorsand, Fahimeh; Haug, Bengt Erik; Kursula, Inari Talvikki; Reuter, Nathalie; Brenk, Ruth (Journal article; Peer reviewed, 2024)Neutrophil proteinase 3 (PR3) is an important drug target for inflammatory lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Drug discovery efforts targeting PR3 require active enzyme for in ... -
Investigating Polypharmacology through Targeting Known Human Neutrophil Elastase Inhibitors to Proteinase 3
Gartan, Parveen; Khorsand, Fahimeh; Mizar, Pushpak; Vahokoski, Juha; Cervantes, Luis F.; Haug, Bengt Erik; Brenk, Ruth; Brooks, Charles L.; Reuter, Nathalie (Journal article; Peer reviewed, 2024)Using a combination of multisite λ−dynamics (MSλD) together with in vitro IC50 assays, we evaluated the polypharmacological potential of a scaffold currently in clinical trials for inhibition of human neutrophil elastase ...