Blar i Bergen Open Research Archive på forfatter "Kleftogiannis, Dimitrios"

Viser treff 1-5 av 5

    • Automated cell type annotation and exploration of single-cell signaling dynamics using mass cytometry 

      Kleftogiannis, Dimitrios; Gavasso, Sonia; Tislevoll, Benedicte Sjo; van der Meer, Nisha; Motzfeldt, Inga Kirstine Flaaten; Hellesøy, Monica; Gullaksen, Stein-Erik; Griessinger, Emmanuel; Fagerholt, Oda Helen Eck; Lenartova, Andrea; Fløisand, Yngvar; Schuringa, Jan Jacob; Gjertsen, Bjørn Tore; Jonassen, Inge (Journal article; Peer reviewed, 2024)
      Mass cytometry by time-of-flight (CyTOF) is an emerging technology allowing for in-depth characterization of cellular heterogeneity in cancer and other diseases. Unfortunately, high-dimensional analyses of CyTOF data remain ...

    • Early response evaluation by single cell signaling profiling in acute myeloid leukemia 

      Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck; Gullaksen, Stein-Erik; Srivastava, Aashish; Birkeland, Even; Kleftogiannis, Dimitrios; Ayuda Duran, Pilar; Piechaczyk, Laure Isabelle; Tadele, Dagim Shiferaw; Skavland, Jørn; Panagiotis, Baliakas; Hovland, Randi; Andresen, Vibeke; Seternes, Ole Morten; Tvedt, Tor Henrik Anderson; Aghaeepour, Nima; Gavasso, Sonia; Porkka, Kimmo; Jonassen, Inge; Fløisand, Yngvar; Enserink, Jorrit; Blaser, Nello; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2023)
      Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a ...

    • Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model 

      Bjørnstad, Ole Vidhammer; Carrasco Fernandez, Manuel; Finne, Kenneth; Ardawatia, Vandana; Winge, Ingeborg; Askeland, Cecilie; Arnes, Jarle; Knutsvik, Gøril; Kleftogiannis, Dimitrios; Paulo, Joao A.; Akslen, Lars Andreas; Vethe, Heidrun (Journal article; Peer reviewed, 2024)
      Background Presence of nerves in tumours, by axonogenesis and neurogenesis, is gaining increased attention for its impact on cancer initiation and development, and the new field of cancer neuroscience is emerging. A recent ...

    • Hypoxia induced responses are reflected in the stromal proteome of breast cancer 

      Kjølle, Silje; Finne, Kenneth; Birkeland, Even; Ardawatia, Vandana; Winge, Ingeborg; Aziz, Sura Mohammed; Knutsvik, Gøril; Wik, Elisabeth; Paulo, Joao A.; Vethe, Heidrun; Kleftogiannis, Dimitrios; Akslen, Lars Andreas (Journal article; Peer reviewed, 2023)
      Cancers are often associated with hypoxia and metabolic reprogramming, resulting in enhanced tumor progression. Here, we aim to study breast cancer hypoxia responses, focusing on secreted proteins from low-grade (luminal-like) ...

    • LOCATOR: feature extraction and spatial analysis of the cancer tissue microenvironment using mass cytometry imaging technologies 

      Ehsani, Rezvan; Jonassen, Inge; Akslen, Lars Andreas; Kleftogiannis, Dimitrios (Journal article; Peer reviewed, 2023)
      Motivation Recent advances in highly multiplexed imaging have provided unprecedented insights into the complex cellular organization of tissues, with many applications in translational medicine. However, downstream ...