• CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma 

      Kleinmanns, Katrin; Bischof, Katharina; Anandan, Shamundeeswari; Popa, Mihaela Lucia; Akslen, Lars A.; Gjertsen, Bjørn Tore; Karlsen, Ida; Fosse, Vibeke Samuelsen; Bjørge, Line; Mc Cormack, Emmet (Journal article; Peer reviewed, 2020)
      Background The survival rate of patients with advanced high-grade serous ovarian carcinoma (HGSOC) remains disappointing. Clinically translatable orthotopic cell line xenograft models and patient-derived xenografts (PDXs) ...
    • CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model 

      Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Davidson, Ben; de Jalón, Elvira Garcia; Tenstad, Olav; Bjørge, Line; McCormack, Emmet (Journal article; Peer reviewed, 2020)
      Background The completeness of resection is a key prognostic indicator in patients with ovarian cancer, and the application of tumour-targeted fluorescence image-guided surgery (FIGS) has led to improved detection of ...
    • Combining Mass Cytometry Data by CyTOFmerge Reveals Additional Cell Phenotypes in the Heterogeneous Ovarian Cancer Tumor Microenvironment: A Pilot Study 

      Thomsen, Liv Cecilie Vestrheim; Kleinmanns, Katrin; Anandan, Shamundeeswari; Gullaksen, Stein-Erik; Abdelaal, Tamim; Iversen, Grete Alræk; Akslen, Lars Andreas; Mc Cormack, Emmet; Bjørge, Line (Journal article; Peer reviewed, 2023-10-23)
      The prognosis of high-grade serous ovarian carcinoma (HGSOC) is poor, and treatment selection is challenging. A heterogeneous tumor microenvironment (TME) characterizes HGSOC and influences tumor growth, progression, and ...
    • Comparison of Five Near-Infrared Fluorescent Folate Conjugates in an Ovarian Cancer Model 

      García de Jalón, Elvira; Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Davidson, Ben; Bjørge, Line; Haug, Bengt Erik; McCormack, Emmet (Journal article; Peer reviewed, 2021)
      Purpose Fluorescence imaging (FLI) using targeted near-infrared (NIR) conjugates aids the detection of tumour lesions pre- and intraoperatively. The optimisation of tumour visualisation and contrast is essential and can ...
    • Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16 

      Casey, Nicholas Paul; Kleinmanns, Katrin; Forcados, Christopher; Gelebart, Pascal Francois; Joaquina, Sandy; Lode, Martine Rott; Benard, Emmanuelle; Kaveh, Fatemeh; Caulier, Benjamin William; Gjerde, Christiane Helgestad; García de Jalón, Elvira; Warren, David; Lindemann, Kristina Yvonne Kathe; Rokkones, Erik; Davidson, Ben; Myhre, Marit; Kvalheim, Gunnar; Bjørge, Line; Mc Cormack, Emmet; Inderberg, Else Marit; Wälchli, Sébastien (Journal article; Peer reviewed, 2024)
      Background Ovarian cancer (OC) is the leading cause of death from gynecologic malignancies in the Western world. Contributing factors include a high frequency of late-stage diagnosis, the development of chemoresistance, ...
    • The emerging role of cd24 in cancer theranostics—a novel target for fluorescence image-guided surgery in ovarian cancer and beyond 

      Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Bjørge, Line; McCormack, Emmet (Journal article; Peer reviewed, 2020)
      Complete cytoreductive surgery is the cornerstone of the treatment of epithelial ovarian cancer (EOC). The application of fluorescence image-guided surgery (FIGS) allows for the increased intraoperative visualization and ...
    • Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes 

      Perrone, Maria Grazia; Vitale, Paola; Miciaccia, Morena; Ferorelli, Savina; Centonze, Antonella; Solidoro, Roberta; Munzone, Cristina; Bonaccorso, Carmela; Fortuna, Cosimo Gianluca; Kleinmanns, Katrin; Bjørge, Line; Scilimati, Antonio (Journal article; Peer reviewed, 2022)
      The identification and removal of all gross and microscopic tumor to render the patient disease free represents a huge challenge in ovarian cancer treatment. The presence of residual disease is an independent negative ...
    • Humanized Ovarian Cancer Patient-Derived Xenografts for Improved Preclinical Evaluation of Immunotherapies 

      Kleinmanns, Katrin; Gullaksen, Stein-Erik; Bredholt, Geir; Davidson, Ben; Torkildsen, Cecilie Fredvik; Grindheim, Sindre; Bjørge, Line; Cormack, Emmet Mc (Journal article; Peer reviewed, 2022)
      High-grade serous ovarian cancer (HGSOC) has poor prognosis and new treatment modalities are needed. Immunotherapy, with checkpoint inhibitors, have demonstrated limited impact. To evaluate the suitability for immunotherapeutics, ...
    • Phenotypic Characterization by Mass Cytometry of the Microenvironment in Ovarian Cancer and Impact of Tumor Dissociation Methods 

      Anandan, Shamundeeswari; Thomsen, Liv Cecilie Vestrheim; Gullaksen, Stein-Erik; Abdelaal, Tamim; Kleinmanns, Katrin; Skavland, Jørn; Bredholt, Geir; Gjertsen, Bjørn Tore; Cormack, Emmet Mc; Bjørge, Line (Journal article; Peer reviewed, 2021)
      Improved molecular dissection of the tumor microenvironment (TME) holds promise for treating high-grade serous ovarian cancer (HGSOC), a gynecological malignancy with high mortality. Reliable disease-related biomarkers are ...