• Acute kidney injury in patients with COVID-19 in the intensive care unit: Evaluation of risk factors and mortality in a national cohort 

      Aukland, Eirik Aasen; Klepstad, Pål; Aukland, Stein Magnus; Zamanzad Ghavidel, Fatemeh; Buanes, Eirik Alnes (Journal article; Peer reviewed, 2022)
      Objectives: Acute kidney injury (AKI) is a frequent complication among critical ill patients with COVID-19, but the actual incidence is unknown as AKI-incidence varies from 25% to 89% in intensive care unit (ICU) populations. ...
    • Clinically significant drug–drug interactions involving opioid analgesics used for pain treatment in patients with cancer: a systematic review 

      Kotlinska-Lemieszek, Aleksandra; Klepstad, Pål; Haugen, Dagny Faksvåg (Peer reviewed; Journal article, 2015-09-16)
      Background: Opioids are the most frequently used drugs to treat pain in cancer patients. In some patients, however, opioids can cause adverse effects and drug–drug interactions. No advice concerning the combination of ...
    • Frailty and survival in elderly intensive care patients in Norway 

      Andersen, Finn Husøy; Haaland, Øystein Ariansen; Klepstad, Pål; Flaatten, Hans (Journal article; Peer reviewed, 2021)
      Background Today, 10%-15% of Norwegian intensive care patients are ≥80 years. This proportion will increase significantly over the next 20 years, but it is unlikely that resources for intensive care increase correspondingly. ...
    • High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting 

      Waagsbø, Bjørn; Stuve, Nora; Afset, Jan Egil; Klepstad, Pål; Mo, Skule; Heggelund, Lars; Damås, Jan Kristian (Journal article; Peer reviewed, 2022)
      Background Bloodstream infections (BSI) occur frequently and are associated with severe outcomes. In this study we aimed to investigate proportions of patients that received discordant empirical antimicrobial therapy and ...
    • Long-term survival and quality of life after intensive care for patients 80 years of age or older 

      Andersen, Finn H; Flaatten, Hans; Klepstad, Pål; Romild, Ulla Kristina; Kvåle, Reidar (Peer reviewed; Journal article, 2015-06-03)
      Background: Comparison of survival and quality of life in a mixed ICU population of patients 80 years of age or older with a matched segment of the general population. Methods: We retrospectively analyzed survival of ICU ...
    • The short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer in a randomized, placebo-controlled, double-blind trial 

      Jakobsen, Gunnhild; Engstrøm, Morten; Hjermstad, Marianne Jensen; Rosland, Jan Henrik; Aass, Nina Kathrine; Albert, Eva; Kaasa, Stein; Fayers, Peter; Klepstad, Pål; Paulsen, Ørnulf (Journal article; Peer reviewed, 2020)
      Purpose: Although corticosteroids are frequently used in patients with advanced cancer, few studies have examined the impact of these drugs on patient-reported sleep. We aimed to examine the short-term impact of ...
    • Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU) 

      Anthon, Carl Thomas; Pène, Frédéric; Perner, Anders; Azoulay, Elie; Puxty, Kathryn; Van De Louw, Andry; Barratt-Due, Andreas; Chawla, Sanjay; Castro, Pedro; Póvoa, Pedro; Coelho, Luis; Metaxa, Victoria; Kochanek, Matthias; Liebregts, Tobias; Kander, Thomas; Hästbacka, Johanna; Andreasen, Jo Bønding; Péju, Edwige; Nielsen, Lene Bjerregaard; Hvas, Christine Lodberg; Dufranc, Etienne; Canet, Emmanuel; Lundqvist, Linda; Wright, Christopher John; Schmidt, Julien; Uhel, Fabrice; Ait-Oufella, Hafid; Krag, Mette; Cos Badia, Elisabet; Díaz-Lagares, Cándido; Menat, Sophie; Voiriot, Guillaume; Clausen, Niels Erikstrup; Lorentzen, Kristian; Kvåle, Reidar; Hildebrandt, Thomas; Holten, Aleksander Rygh; Strand, Kristian; Tzalavras, Asterios; Bestle, Morten Heiberg; Klepstad, Pål; Fernandez, Sara; Vimpere, Damien; Paulino, Carolina; Graça, Carina; Lueck, Catherina; Juhl, Christian Svendsen; Costa, Carolina; Bådstøløkken, Per Martin; Miranda, Teresa; Lêdo, Lia Susana Aires; Sousa Torres, Joao Carlos; Granholm, Anders; Møller, Morten Hylander; Russell, Lene; Khalil, Ahmed; Yehia, Ahmed; Salem, Haney; Farahat, Hesham; Sudevan, Manu; Biggart, Melissa; Fatima, Nirmeen; Elkhonezy, Mohammed; Bunzel, Anne-Marie; Siegumfeldt, Rine M.; Vestergaard, Stine R.; Pelle, Juliette; Lê, Minh-Pierre; Vigneron, Clara; Bertrix, Morgane; Cirera, Paul; Laghlam, Driss; Bredin, Swann; Marin, Nathalie; Toppenberg, Maria; Benelli, Brice; Seguin, Amélie; Garret, Charlotte; Guillotin, Florian; Blonz, Gauthier; Lascarrou, Jean-Baptiste; Lemarie, Jérémie; Desmedt, Luc; Agbakou, Maïté; Carpentier, Mathieu; Martin, Maëlle; Benkalfate, Naïla; Zambon, Olivier; Decamps, Paul; Wilquin, Pauline L.; Benguerfi, Soraya; Gardner, John; Remor, Natalie; Carr, Sheila; Yang, Gloria; Gernez, Coralie; Thiry, Ingrid; Missri, Louai; Denneborg, Moritz K. G.; Brown, Katherine; Casares, Vanessa; Sivula, Mirka; Lappi, Elina; Pettilä, Leena; Heinonen, Jonna; Saario, Minttu; Mecheri, Manal K.; Elabbadi, Alezandre; Desnos, Cyrielle; Lafarge, Antoine; Mghirbi, Olfa; Sjøbø, Brit Ågot; Christoffersen, Cecilie; Bestle, Frederik H.; Lemos, Claudia; Gonçalves, Cristiana V.; Jacinto, Nuno M. B.; Anselmo, Monica P.; Hoeper, Marius M.; Hoff, Marja; Simões Freire, Pedro M. (Journal article; Peer reviewed, 2023)
      Purpose Thrombocytopenia (platelet count < 150 × 109/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on ...