Browsing Bergen Open Research Archive by Author "Knutsvik, Gøril"
Now showing items 1-4 of 4
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Biomarkers in breast cancer, with special focus on tumor cell proliferation
Knutsvik, Gøril (Doctoral thesis, 2016-10-31)Background: Breast cancer is a heterogeneous disease encompassing distinct subtypes that differ in incidence and prognosis. Better characterization of established biomarkers and exploration of novel biomarkers and possible ... -
Evaluation of Ki67 expression across distinct categories of breast cancer specimens: A Population-based study of matched surgical specimens, core needle biopsies and tissue microarrays
Knutsvik, Gøril; Stefansson, Ingunn; Aziz, Sura Mohammed; Arnes, Jarle; Eide, Johan; Collett, Karin; Akslen, Lars A. (Peer reviewed; Journal article, 2014-11-06)Introduction: Tumor cell proliferation in breast cancer is strongly prognostic and may also predict response to chemotherapy. However, there is no consensus on counting areas or cut-off values for patient stratification. ... -
Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes
Smeland, Hilde Ytre-Hauge; Askeland, Cecilie; Wik, Elisabeth; Knutsvik, Gøril; Molven, Anders; Edelmann, RJ; Reed, Rolf K.; Warren, DJ; Gullberg, Donald; Stuhr, Linda Elin Birkhaug; Akslen, Lars A. (Peer reviewed; Journal article, 2020)Cancer‐associated fibroblasts are essential modifiers of the tumor microenvironment. The collagen‐binding integrin α11β1 has been proposed to be upregulated in a pro‐tumorigenic subtype of cancer‐associated fibroblasts. ... -
Stathmin expression associates with vascular and immune responses in aggressive breast cancer subgroups
Askeland, Cecilie; Wik, Elisabeth; Finne, Kenneth; Birkeland, Even; Arnes, Jarle; Collett, Karin; Knutsvik, Gøril; Krüger, Kristi; Davidsen, Benedicte; Aas, Turid; Eide, Geir Egil; Stefansson, Ingunn; Foulkes, William; Akslen, Lars A. (Journal article; Peer reviewed, 2020)Studies indicate that stathmin expression associates with PI3K activation in breast cancer, suggesting stathmin as a marker for targetable patient subgroups. Here we assessed stathmin in relation to tumour proliferation, ...