Blar i Bergen Open Research Archive på forfatter "Knutsvik, Gøril"
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Biomarkers in breast cancer, with special focus on tumor cell proliferation
Knutsvik, Gøril (Doctoral thesis, 2016-10-31)Background: Breast cancer is a heterogeneous disease encompassing distinct subtypes that differ in incidence and prognosis. Better characterization of established biomarkers and exploration of novel biomarkers and possible ... -
Detection and significance of small and low proliferation breast cancer
Hofvind, Solveig; Knutsvik, Gøril; Holen, Åsne Sørlien; Tsuruda, Kaitlyn; Akslen, Lars Andreas (Journal article; Peer reviewed, 2022)Objectives To determine the frequency and discuss possible implications of early breast cancer with particularly good prognosis and defined by tumor diameter and cell proliferation. Setting Detection of small and ... -
Evaluation of Ki67 expression across distinct categories of breast cancer specimens: A Population-based study of matched surgical specimens, core needle biopsies and tissue microarrays
Knutsvik, Gøril; Stefansson, Ingunn; Aziz, Sura Mohammed; Arnes, Jarle; Eide, Johan; Collett, Karin; Akslen, Lars A. (Peer reviewed; Journal article, 2014-11-06)Introduction: Tumor cell proliferation in breast cancer is strongly prognostic and may also predict response to chemotherapy. However, there is no consensus on counting areas or cut-off values for patient stratification. ... -
Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes
Smeland, Hilde Ytre-Hauge; Askeland, Cecilie; Wik, Elisabeth; Knutsvik, Gøril; Molven, Anders; Edelmann, RJ; Reed, Rolf K.; Warren, DJ; Gullberg, Donald; Stuhr, Linda Elin Birkhaug; Akslen, Lars A. (Peer reviewed; Journal article, 2020)Cancer‐associated fibroblasts are essential modifiers of the tumor microenvironment. The collagen‐binding integrin α11β1 has been proposed to be upregulated in a pro‐tumorigenic subtype of cancer‐associated fibroblasts. ... -
Stathmin expression associates with vascular and immune responses in aggressive breast cancer subgroups
Askeland, Cecilie; Wik, Elisabeth; Finne, Kenneth; Birkeland, Even; Arnes, Jarle; Collett, Karin; Knutsvik, Gøril; Krüger, Kristi; Davidsen, Benedicte; Aas, Turid; Eide, Geir Egil; Stefansson, Ingunn; Foulkes, William; Akslen, Lars A. (Journal article; Peer reviewed, 2020)Studies indicate that stathmin expression associates with PI3K activation in breast cancer, suggesting stathmin as a marker for targetable patient subgroups. Here we assessed stathmin in relation to tumour proliferation, ...