Browsing Bergen Open Research Archive by Author "Koivunen, Jarkko"

Now showing items 1-3 of 3

    • Integrin α11β1 is a receptor for collagen XIII 

      Koivunen, Jarkko; Tu, Hongmin; Kemppainen, Antti; Anbazhagan, Padmanabhan; Finnilä, Mikko A; Saarakkala, Simo; Käpylä, Jarmo; Lu, Ning; Heikkinen, Anne; Juffer, André H; Heino, Jyrki; Gullberg, Donald; Taina, Pihlajaniemi (Journal article; Peer reviewed, 2021)
      Collagen XIII is a conserved transmembrane collagen mainly expressed in mesenchymal tissues. Previously, we have shown that collagen XIII modulates tissue development and homeostasis. Integrins are a family of receptors ...

    • Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis 

      Petäistö, Tiina; Vicente, David; Mäkelä, Kari A; Finnilä, Mikko A; Miinalainen, Ilkka; Koivunen, Jarkko; Izzi, Valerio; Aikio, Mari; Karppinen, Sanna-Maria; Davarajan, Raman; Thevenot, Jerome; Herzig, Karl-Heinz; Heljasvaara, Ritva Leena; Pihlajaniemi, Taina (Journal article; Peer reviewed, 2020)
      Liver and adipose tissues play important roles in the regulation of systemic glucose and lipid metabolism. Extracellular matrix synthesis and remodelling are significantly altered in these tissues in obesity and type 2 ...

    • Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis 

      Martínez-Nieto, Guillermo A.; Teppo, Hanna-Riikka; Petrelius, Noora; Izzi, Valerio; Devarajan, Raman; Petäistö, Tiina; Liu, Hengshuo; Kim, Kris S.; Karppinen, Sanna-Maria; Ruotsalainen, Heli; Koivunen, Jarkko; Mäki, Joni M.; Walker, Gilbert C.; Pihlajaniemi, Taina; Gullberg, Elon Donald; Heljasvaara, Ritva Leena (Journal article; Peer reviewed, 2022)
      Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing. The expression of the α11 is upregulated in cancer-associated ...