• Identification of immune-related genes contributing to the development of glioblastoma using weighted gene co-expression network analysis 

      Kong, Yang; Feng, Zichao; Zhang, Yulin; Liu, Xiaofei; Ma, Yuan; Zhao, Zhimin; Huang, Bin; Chen, An-Jing; Zhang, Di; Thorsen, Frits; Wang, Jian; Yang, Ning; Li, Xingang (Journal article; Peer reviewed, 2020)
      Background: The tumor microenvironment (TME) of human glioblastoma (GBM) exhibits considerable immune cell infiltration, and such cell types have been shown to be widely involved in the development of GBM. Here, weighted ...
    • Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastoma 

      Han, Mingzhi; Wang, Shuai; Zhao, Wen-Bo; Ni, Shi-Lei; Yang, Ning; Kong, Yang; Huang, Bin; Chen, An-Jing; Li, Xin-Gang; Wang, Jian; Wang, Dong-Hai (Peer reviewed; Journal article, 2019)
      Background: Dysregulation of immune checkpoint molecules leads to immune evasion in human tumours but has become a viable target for tumour therapy. Here, we examined expression of Herpes virus entry mediator (HVEM), an ...
    • LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM 

      Zheng, Jingfang; Su, Zhiying; Kong, Yang; Lin, Qingping; Liu, Hongli; Wang, Yanlong; Wang, Jian (Journal article; Peer reviewed, 2020)
      Rigorous molecular characterization of biological systems has uncovered a variety of gene variations underlying normal and disease states and a remarkable complexity in the forms of RNA transcripts that exist. A recent ...
    • Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines 

      Zhang, Yulin; Kong, Yang; Ma, Yuan; Ni, Shilei; Wikerholmen, Tobias Espedal; Xi, Kaiyan; Zhao, Feihu; Zhao, Zhimin; Wang, Junpeng; Huang, Bin; Chen, Anjing; Yao, Zhong; Han, Mingzhi; Feng, Zichao; Hu, Yaotian; Thorsen, Frits; Wang, Jiang; Li, Xingang (Journal article; Peer reviewed, 2021)
      Dysregulated iron metabolism is a hallmark of many cancers, including glioblastoma (GBM). However, its role in tumor progression remains unclear. Herein, we identified coatomer protein complex subunit zeta 1 (COPZ1) as a ...
    • The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma 

      Kong, Yang; Feng, Zichao; Chen, Anjing; Qi, Qichao; Han, Mingzhi; Wang, Shuai; Zhang, Yulin; Zhang, Xin; Yang, Ning; Wang, Jiwei; Huang, Bin; Zhang, Qing; Xiang, Guo; Li, Wenjie; Zhang, Di; Wang, Jian; Li, Xingang (Peer reviewed; Journal article, 2019-09-27)
      Galangin (GG), a flavonoid, elicits a potent antitumor activity in diverse cancers. Here, we evaluated the efficacy of GG in the treatment of human glioblastoma multiforme (GBM) and investigated the molecular basis for its ...
    • Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma. 

      Feng, Zichao; Zhou, Wenjing; Wang, Jiwei; Qi, Qichao; Han, Mingzhi; Kong, Yang; Hu, Yaotian; Zhang, Yulin; Chen, Anbin; Huang, Bin; Zhang, Di; Li, Wenjie; Zhang, Qing; Bjerkvig, Rolf; Wang, Jian; Thorsen, Frits; Li, Xingang (Peer reviewed; Journal article, 2019-11-28)
      Proteolipid protein 2 (PLP2) is an integral ion channel membrane protein of the endoplasmic reticulum. The protein has been shown to be highly expressed in many cancer types, but its importance in glioma progression is ...