Blar i Bergen Open Research Archive på forfatter "Kotopoulis, Spiros"

Viser treff 1-11 av 11

    • Formulation and characterisation of drug-loaded antibubbles for image-guided and ultrasound-triggered drug delivery 

      Kotopoulis, Spiros; Lam, Christina; Haugse, Ragnhild; Snipstad, Sofie; Murvold, Elsa Thodesen; Jouleh, Tæraneh; Berg, Sigrid; Hansen, Rune; Popa, Mihaela-Lucia; Mccormack, Emmet Matin; Gilja, Odd Helge; Poortinga, Albert (Journal article; Peer reviewed, 2022)
      The aim of this study was to develop high load-capacity antibubbles that can be visualized using diagnostic ultrasound and the encapsulated drug can be released and delivered using clinically translatable ultrasound. The ...

    • A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer 

      Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen; Hoem, Dag; Schjøtt, Jan; Gjertsen, Bjørn Tore; Biermann, Martin; Molven, Anders; Sorbye, Halfdan; McCormack, Emmet; Postema, Michiel; Gilja, Odd Helge (Peer reviewed; Journal article, 2016-12)
      Background: The primary aim of our study was to evaluate the safety and potential toxicity of gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer patients. The secondary aim was to ...

    • Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines 

      Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan; Kamceva, Tina; Cros-Perrial, Emeline; Langer, Anika; de Garibay, Gorka Ruiz; Kotopoulis, Spiros; McCormack, Emmet; Riedel, Bettina (Journal article; Peer reviewed, 2020)
      Cytidine deaminase (CDA) is a determinant of in vivo gemcitabine elimination kinetics and cellular toxicity. The impact of CDA activity in pancreatic ductal adenocarcinoma (PDAC) cell lines has not been elucidated. We ...

    • Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells 

      Haugse, Ragnhild; Langer, Anika; Gullaksen, Stein-Erik; Sundøy, Silje Maria; Gjertsen, Bjørn Tore; Kotopoulis, Spiros; Mc Cormack, Emmet (Peer reviewed; Journal article, 2019-07-06)
      Treatment with ultrasound and microbubbles (sonoporation) to enhance therapeutic efficacy in cancer therapy is rapidly expanding, but there is still very little consensus as to why it works. Despite the original assumption ...

    • Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells 

      Haugse, Ragnhild; Langer, Anika; Murvold, Elsa Thodesen; Costea, Daniela Elena; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Kotopoulis, Spiros; Ruiz de Garibay, Gorka; McCormack, Emmet (Journal article; Peer reviewed, 2020)
      The use of ultrasound (US) and microbubbles (MB), usually referred to as sonoporation, has great potential to increase the efficacy of chemotherapy. However, the molecular mechanisms that mediate sonoporation response are ...

    • Nonlinear echoes from encapsulated antibubbles 

      Johansen, Kristoffer; Kotopoulis, Spiros; Poortinga, Albert T.; Postema, Michiel (Peer reviewed; Journal article, 2015-09-19)
      An antibubble consists of a liquid droplet, surrounded by a gas, often with an encapsulating shell. Antibubbles of microscopic sizes suspended in fluids are acoustically active in the ultrasonic range. Antibubbles have ...

    • Real-time intravital multiphoton microscopy to visualize focused ultrasound and microbubble treatments to increase blood-brain barrier permeability 

      Poon, Charissa; Mühlenpfordt, Melina; Olsman, Marieke; Kotopoulis, Spiros; Davies, Catharina de Lange; Hynynen, Kullervo (Journal article; Peer reviewed, 2022)
      The blood-brain barrier (BBB) is a key challenge for the successful delivery of drugs to the brain. Ultrasound exposure in the presence of microbubbles has emerged as an effective method to transiently and locally increase ...

    • SonoVue® vs. Sonazoid™ vs. Optison™: Which Bubble Is Best for Low-Intensity Sonoporation of Pancreatic Ductal Adenocarcinoma? 

      Kotopoulis, Spiros; Popa, Mihaela-Lucia; Mayoral Safont, Mireia; Murvold, Elsa Thodesen; Haugse, Ragnhild; Langer, Anika; Dimcevski, Georg Gjorgji; Lam, Christina; Bjånes, Tormod Karlsen; Gilja, Odd Helge; Mccormack, Emmet Matin (Journal article; Peer reviewed, 2022)
      The use of ultrasound and microbubbles to enhance therapeutic efficacy (sonoporation) has shown great promise in cancer therapy from in vitro to ongoing clinical studies. The fastest bench-to-bedside translation involves ...

    • Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation 

      van Wamel, Annemieke; Mühlenpfordt, Melina; Hansen, Rune; Healey, Andrew; Villanueva, Flordeliza S.; Kotopoulis, Spiros; Davies, Catharina de Lange; Chen, Xucai (Journal article; Peer reviewed, 2022)
      Acoustic Cluster Therapy (ACT®) is a platform for improving drug delivery and has had promising pre-clinical results. A clinical trial is ongoing. ACT® is based on microclusters of microbubbles–microdroplets that, when ...

    • Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys 

      Eikrem, Øystein Solberg; Kotopoulis, Spiros; Popa, Mihaela-Lucia; Safont, Mireia Mayoral; Fossan, Kjell Ove; Leh, Sabine; Landolt, Lea; Babickova, Janka; Gudbrandsen, Oddrun Anita; Gilja, Odd Helge; Riedel, Bettina Maria Ingeborg; Schjøtt, Jan Didrik; McCormack, Emmet; Marti, Hans-Peter (Journal article; Peer reviewed, 2021-11-29)
      The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ...

    • Ultrasound- and Microbubble-Assisted Gemcitabine Delivery to Pancreatic Cancer Cells 

      Bjånes, Tormod Karlsen; Kotopoulis, Spiros; Murvold, Elsa Thodesen; Kamceva, Tina; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Schjøtt, Jan; Riedel, Bettina; McCormack, Emmet (Journal article; Peer reviewed, 2020)
      Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death worldwide. Poor drug delivery to tumours is thought to limit chemotherapeutic treatment efficacy. Sonoporation combines ultrasound (US) and microbubbles ...