• AJAM-A–tetraspanin–αvβ5 integrin complex regulates contact inhibition of locomotion 

      Kummer, Daniel; Steinbacher, Tim; Thölmann, Sonja; Schwietzer, Mariel Flavia; Hartmann, Christian; Horenkamp, Simone; Demuth, Sabrina; Peddibhotla, Swetha S.D.; Brinkmann, Frauke; Kemper, Björn; Schnekenburger, Jürgen; Brandt, Matthias; Betz, Timo; Liashkovich, Ivan; Kouzel, Ivan; Shahin, Victor; Corvaia, Nathalie; Rottner, Klemens; Tarbashevich, Katsiaryna; Raz, Erez; Greune, Lilo; Alexander Schmidt, Schmidt; Gerke, Volker; Ebnet, Klaus (Journal article; Peer reviewed, 2022)
      Contact inhibition of locomotion (CIL) is a process that regulates cell motility upon collision with other cells. Improper regulation of CIL has been implicated in cancer cell dissemination. Here, we identify the cell ...
    • Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis 

      Gahan, James Michael; Kouzel, Ivan; Ormevik Jansen, Kamilla; Burkhardt, Pawel; Rentzsch, Fabian (Journal article; Peer reviewed, 2022)
      Chromatin regulation is a key process in development but its contribution to the evolution of animals is largely unexplored. Chromatin is regulated by a diverse set of proteins, which themselves are tightly regulated in a ...
    • NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis 

      Lemaitre, Quentin Indiana Bruno; Bartsch, Natascha; Kouzel, Ivan; Busengdal, Henriette; Richards, Gemma Sian; Steinmetz, Patrick; Rentzsch, Fabian (Journal article; Peer reviewed, 2023)
      Neurogenesis has been studied extensively in the ectoderm, from which most animals generate the majority of their neurons. Neurogenesis from non-ectodermal tissue is, in contrast, poorly understood. Here we use the cnidarian ...
    • RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells 

      Kouzel, Ivan; Kehl, Alexander; Berger, Petya; Liashkovich, Ivan; Steil, Daniel; Makalowski, Wojciech; Suzuki, Yutaka; Pohlentz, Gottfried; Karch, Helge; Mellmann, Alexander C.; Müthing, Johannes (Journal article; Peer reviewed, 2020-03-18)
      The cardinal virulence factor of human-pathogenic enterohaemorrhagic Escherichia coli (EHEC) is Shiga toxin (Stx), which causes severe extraintestinal complications including kidney failure by damaging renal endothelial ...