Browsing Bergen Open Research Archive by Author "Kråkenes, Torbjørn"
Now showing items 1-10 of 10
-
Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation
Liang, Xiao; Chen, Anbin; Kianian, Atefeh; Kristiansen, Cecilie Katrin; Tsering Yangzom, Tsering Yangzom; Furriol Palmer, Jessica; Høyland, Lena Elise; Ziegler, Mathias; Kråkenes, Torbjørn; Tzoulis, Charalampos; Fang, Fei; Sullivan, Gareth John; Bindoff, Laurence Albert (Journal article; Peer reviewed, 2024)Mitochondrial diseases are associated with neuronal death and mtDNA depletion. Astrocytes respond to injury or stimuli and damage to the central nervous system. Neurodegeneration can cause astrocytes to activate and acquire ... -
CDR2L Is the Major Yo Antibody Target in Paraneoplastic Cerebellar Degeneration
Kråkenes, Torbjørn; Herdlevær, Ida Ajvazi; Raspotnig, Margrethe; Haugen, Mette; Schubert, Manja; Vedeler, Christian A. (Peer reviewed; Journal article, 2019)The pathogenesis of Yo‐mediated paraneoplastic cerebellar degeneration (PCD) is unclear. We applied cerebrospinal fluid and serum from PCD patients as well as CDR2 and CDR2L antibodies to neuronal tissue, cancer cell lines, ... -
Development and Optimization of a Multilayer Rat Purkinje Neuron Culture
Uggerud, Ida Margrethe; Kråkenes, Torbjørn; Hirai, Hirokazu; Vedeler, Christian Alexander; Schubert, Manja (Journal article; Peer reviewed, 2023)Elucidation of the mechanisms involved in neurodegenerative diseases of the cerebellum has been hampered by the lack of robust single cell models to study Purkinje neurons and replicate at the same time in vivo features. ... -
Localization of CDR2L and CDR2 in paraneoplastic cerebellar degeneration
Herdlevær, Ida Ajvazi; Kråkenes, Torbjørn; Schubert, Manja; Vedeler, Christian A. (Journal article; Peer reviewed, 2020)Objective: Identify the subcellular location and potential binding partners of two cerebellar degeneration‐related proteins, CDR2L and CDR2, associated with anti‐Yo‐mediated paraneoplastic cerebellar degeneration. Methods: ... -
Multi-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L
Solheim, Eirik Tveit; Gerking, Yola; Kråkenes, Torbjørn; Herdlevær, Ida; Birkeland, Even; Totland, Cecilie; Dick, Fiona; Vedeler, Christian Alexander (Journal article; Peer reviewed, 2024)Background Cerebellar degeneration-related (CDR) proteins are associated with paraneoplastic cerebellar degeneration (PCD) – a rare, neurodegenerative disease caused by tumour-induced autoimmunity against neural antigens ... -
The neuroprotective potential of mesenchymal stem cells from bone marrow and human exfoliated deciduous teeth in a murine model of demyelination
Kråkenes, Torbjørn; Wergeland, Stig; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Fromreide, Siren; Costea, Daniela Elena; Mustafa, Kamal Babikeir Elnour; Bø, Lars; Kvistad, Christopher Elnan (Journal article; Peer reviewed, 2023)Introduction Multiple sclerosis (MS) is characterized by chronic inflammation, demyelination, and axonal degeneration within the central nervous system (CNS), for which there is no current treatment available with the ... -
Paraneoplastic cerebellar degeneration: Characterizing the Yo antibody antigens
Kråkenes, Torbjørn (Doctoral thesis, 2021-03-16)Background: The pathogenesis of paraneoplastic cerebellar degeneration (PCD) with Yo-antibodies is unclear. The disease is generally accepted as immune-mediated, but whether the Yo antibodies themselves are pathogenic ... -
Safety and Clinical Efficacy of Mesenchymal Stem Cell Treatment in Traumatic Spinal Cord Injury, Multiple Sclerosis and Ischemic Stroke – A Systematic Review and Meta-Analysis
Kvistad, Christopher Elnan; Kråkenes, Torbjørn; Gjengedal, Gudveig Cecilie Gjerde; Mustafa, Kamal Babikeir Elnour; Rekand, Tiina; Bø, Lars (Journal article; Peer reviewed, 2022-05-30)Background: Mesenchymal stem cells (MSCs) is an attractive candidate in regenerative research and clinical trials have assessed their therapeutic potential in different neurological conditions with disparate etiologies. ... -
The Therapeutic Mechanisms of Mesenchymal Stem Cells in MS—A Review Focusing on Neuroprotective Properties
Gavasso, Sonia; Kråkenes, Torbjørn; Olsen, Håkon; Evjenth, Elisabeth Claire; Ytterdal, Marie; Haugsøen, Jonas Bull; Kvistad, Christopher Elnan (Journal article; Peer reviewed, 2024-01-23)In multiple sclerosis (MS), there is a great need for treatment with the ability to suppress compartmentalized inflammation within the central nervous system (CNS) and to promote remyelination and regeneration. Mesenchymal ... -
The Therapeutic Potential of Exosomes from Mesenchymal Stem Cells in Multiple Sclerosis
Kråkenes, Torbjørn; Sandvik, Casper Eugen; Ytterdal, Marie; Gavasso, Sonia; Evjenth, Elisabeth Claire; Bø, Lars; Kvistad, Christopher Elnan (Journal article; Peer reviewed, 2024)Although treatment for multiple sclerosis (MS) has undergone a revolution in the last decades, at least two important barriers remain: alleviation of innate inflammation driving disease progression and promotion of ...