• Addition of IMP3 to L1CAM for discrimination between low- and high-grade endometrial carcinomas: a European Network for Individualised Treatment of Endometrial Cancer collaboration study 

      Visser, Nicole C.M.; van der Putten, Louis J.M.; van Egerschot, Alex; van de Vijver, Koen K.; Santacana, Maria; Bronsert, Peter; Hirschfeld, Marc; Colas, Eva; Gil-Moreno, Antonio; Garcia, Angel; Mancebo, Gemma; Alameda, Francesc; Krakstad, Camilla; Tangen, Ingvild Løberg; Huvila, Jutta; Schrauwen, Stefanie; Koskas, Martin; Walker, Francine; Weinberger, Vit; Minar, Lubos; Hausnerova, Jitka; Snijders, Marc P.L.M.; van den Berg-van Erp, Saskia; Matias-Guiu, Xavier; Trovik, Jone; Amant, Frédéric; Massuger, Leon F.A.G.; Bulten, Johan; Pijnenborg, Johanna M.A. (Peer reviewed; Journal article, 2019)
      Discrimination between low- and high-grade endometrial carcinomas (ECs) is clinically relevant but can be challenging for pathologists, with moderate interobserver agreement. Insulin-like growth factor-II mRNA-binding ...
    • Androgen receptor as potential therapeutic target in metastatic endometrial cancer 

      Tangen, Ingvild Løberg; Onyango, Therese Bredholt; Kopperud, Reidun Kristin; Berg, Anna; Halle, Mari Kyllesø; Øyan, Anne Margrete; Werner, Henrica Maria Johanna; Trovik, Jone; Kalland, Karl-Henning; Salvesen, Helga Birgitte; Krakstad, Camilla (Peer reviewed; Journal article, 2016-06-30)
      Purpose: The expression and involvement of estrogen (ER) and progesterone receptor (PR) is extensively studied in endometrial cancer. Androgen receptor (AR) is a hormone receptor less studied in female cancers, and we here ...
    • Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival 

      Mauland, Karen Klepsland; Wik, Elisabeth; Høivik, Erling Andre; Kusonmano, Kanthida; Halle, Mari Kyllesø; Berg, Anna; Haugland, Hans Kristian; Øyan, Anne Margrete; Kalland, Karl-Henning; Stefansson, Ingunn Marie; Akslen, Lars A.; Krakstad, Camilla; Trovik, Jone; Werner, Henrica Maria Johanna; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2017)
      Aneuploidy is a widely studied prognostic marker in endometrial cancer (EC), however, not implemented in clinical decision-making. It lacks validation in large prospective patient cohorts adjusted for currently standard ...
    • ATAD2 overexpression links to enrichment of B-MYBtranslational signatures and development of aggressive endometrial carcinoma 

      Krakstad, Camilla; Tangen, Ingvild Løberg; Høivik, Erling Andre; Halle, Mari Kyllesø; Berg, Anna; Werner, Henrica Maria Johanna; Ræder, Maria B.; Kusonmano, Kanthida; Zou, June; Øyan, Anne Margrete; Stefansson, Ingunn; Trovik, Jone; Kalland, Karl-Henning; Chen, Hong-Wu; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2015)
      We have explored the potential for clinical implementation of ATAD2 as a biomarker for aggressive endometrial cancer by investigating to what extent immunohistochemical (IHC) staining for ATAD2 is feasible, reflects clinical ...
    • Automated segmentation of endometrial cancer on MR images using deep learning 

      Hodneland, Erlend; Dybvik, Julie Andrea; Wagner-Larsen, Kari Strøno; Solteszova, Veronika; Zanna, Antonella; Fasmer, Kristine Eldevik; Krakstad, Camilla; Lundervold, Arvid; Lundervold, Alexander Selvikvåg; Salvesen, Øyvind; Erickson, Bradley J.; Haldorsen, Ingfrid S (Journal article; Peer reviewed, 2021)
      Preoperative MR imaging in endometrial cancer patients provides valuable information on local tumor extent, which routinely guides choice of surgical procedure and adjuvant therapy. Furthermore, whole-volume tumor analyses ...
    • Blood Metabolites Associate with Prognosis in Endometrial Cancer 

      Strand, Elin; Tangen, Ingvild Løberg; Fasmer, Kristine Eldevik; Jacob, Havjin; Halle, Mari Kyllesø; Hoivik, Erling A; Delvoux, Bert; Trovik, Jone; Haldorsen, Ingfrid S.; Romano, Andrea; Krakstad, Camilla (Peer reviewed; Journal article, 2019-12-14)
      Endometrial cancer has a high prevalence among post-menopausal women in developed countries. We aimed to explore whether certain metabolic patterns could be related to the characteristics of aggressive disease and poorer ...
    • Blood steroid levels predict survival in endometrial cancer and reflect tumor estrogen signaling 

      Forsse, David Erik; Tangen, Ingvild Løberg; Fasmer, Kristine Eldevik; Halle, Mari Kyllesø; Viste, Kristin; Almås, Bjørg; Bertelsen, Bjørn-Erik; Trovik, Jone; Haldorsen, Ingfrid S.; Krakstad, Camilla (Peer reviewed; Journal article, 2020-02)
      Objective Blood-based biomarkers are attractive due to ease of sampling and standardized measurement technology, reducing obstacles to clinical implementation. The objective of this study was to evaluate a clinically ...
    • Cancer awareness in the general population varies with sex, age and media coverage: A population-based survey with focus on gynecologic cancers 

      Fonnes, Tina; Telle, Ingrid Ovidia Moe; Forsse, David Erik; Falck, Runa; Trovik, Jone; Haldorsen, Ingfrid S.; Krakstad, Camilla (Journal article; Peer reviewed, 2021)
      Objectives There is a need for more knowledge about the public awareness and attitudes towards gynecologic cancers. We employed a research-purpose population-based citizen panel to assess how often people recall gynecologic ...
    • Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer 

      Lawrenson, Kate; Li, Qiyuan; Kar, Siddhartha; Seo, Ji-Heui; Tyrer, Jonathan; Spindler, Tassja J.; Lee, Janet; Chen, Yibu; Karst, Alison; Drapkin, Ronny; Aben, Katja K.H.; Anton-Culver, Hoda; Antonenkova, Natalia; Baker, Helen; Bandera, Elisa V.; Bean, Yukie; Beckmann, Matthias W.; Berchuck, Andrew; Bisogna, Maria; Bjørge, Line; Bogdanova, Natalia; Brinton, Louise A.; Brooks-Wilson, Angela; Bruinsma, Fiona; Butzow, Ralf; Campbell, Ian G.; Carty, Karen; Chang-Claude, Jenny; Chenevix-Trench, Georgia; Chen, Anne; Chen, Zhihua; Cook, Linda S.; Cramer, Daniel W.; Cunningham, Julie M.; Cybulski, Cezary; Dansonka-Mieszkowska, Agnieszka; Dennis, Joe; Dicks, Ed; Doherty, Jennifer A.; Dörk, Thilo; Du Bois, Andreas; Durst, Matthias; Eccles, Diana; Easton, Douglas T.; Edwards, Robert P.; Eilber, Ursula; Ekici, Arif B.; Fasching, Peter A.; Fridley, Brooke L.; Gao, Yu-Tang; Gentry-Maharaj, Aleksandra; Giles, Graham G.; Glasspool, Rosalind; Goode, Ellen L.; Goodman, Marc T.; Grownwald, Jacek; Harrington, Patricia; Harter, Philipp; Hasmad, Hanis Nazihah; Hein, Alexander; Heitz, Florian; Hildebrandt, Michelle A.T.; Hillemanns, Peter; Hogdall, Estrid; Hogdall, Claus; Hosono, Satoyo; Iversen, Edwin S.; Jakubowska, Anna; James, Paul; Jensen, Allan; Ji, Bu-Tian; Karlan, Beth Y.; Kjær, Susanne Krüger; Kelemen, Linda E.; Kellar, Melissa; Kelley, Joseph L.; Kiemeney, Lambertus A.; Krakstad, Camilla; Kupryjanczyk, Jolanta; Lambrechts, Diether; Lambrechts, Sandrina; Le, Nhu D.; Lee, Alice W.; Lele, Shashi; Leminen, Arto; Lester, Jenny; Levine, Douglas A.; Liang, Dong; Lissowska, Jolanta; Lu, Karen; Lubinski, Jan; Lundvall, Lene; Massuger, Leon F.A.G.; Matsuo, Keitaro; McGuire, Valerie; McLaughlin, John R.; Nevanlinna, Heli; McNeish, Ian; Menon, Usha; Modugno, Francesmary; Moysich, Kirsten B.; Narod, Steven A.; Nedergaard, Lotte; Ness, Roberta B.; Azmi, Mat Adenan Noor; Odunsi, Kunle; Olson, Sara H.; Orlow, Irene; Orsulic, Sandra; Weber, Rachel Palmieri; Pearce, Celeste L.; Pejovic, Tanja; Pelttari, Liisa M.; Permuth-Wey, Jennifer; Phelan, Catherine M.; Pike, Malcolm C.; Poole, Elizabeth M.; Ramus, Susan J.; Risch, Harvey A.; Rosen, Barry; Rossing, Mary Anne; Rothstein, Joseph H.; Rudolph, Anja; Runnebaum, Ingo B.; Rzepecka, Iwona K.; Salvesen, Helga; Schildkraut, Joellen M; Schwaab, Ira; Sellers, Thomas A.; Shu, Xiao-Ou; Shvetsov, Yurii B.; Siddiqui, Nadeem; Sieh, Weiva; Song, Honglin; Southey, Melissa C.; Sucheston, Lara; Tangen, Ingvild Løberg; Teo, Soo-Hwang; Terry, Kathryn L.; Thompson, Pamela J.; Timorek, Agnieszka; Tsai, Ya-Yu; Tworoger, Shelley S.; van Altena, Anne M.; Van Nieuwenhuysen, Els; Vergote, Ignace; Vierkant, Robert A.; Wang-Gohrke, Shan; Walsh, Christine; Wentzensen, Nicolas; Whittemore, Alice S.; Wicklund, Kristine G.; Wilkens, Lynne R.; Woo, Yin-Ling; Wu, Xifeng; Wu, Anna H.; Yang, Hannah; Zheng, Wei; Ziogas, Argyrios; Monteiro, Alvaro; Pharoah, Paul D.; Gayther, Simon A.; Freedman, Matthew L.; Bowtell, David; Webb, Penelope M.; DeFazio, Anna (Peer reviewed; Journal article, 2015-09-22)
      Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility ...
    • Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer 

      Mazloumi Gavgani, Fatemeh; Arnesen, Victoria Smith; Jacobsen, Rhian Gaenor; Krakstad, Camilla; Høivik, Erling Andre; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2018-12-07)
      The phosphoinositide 3-kinase (PI3K) signalling pathway is highly dysregulated in cancer, leading to elevated PI3K signalling and altered cellular processes that contribute to tumour development. The pathway is normally ...
    • Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma 

      Berg, Hege Fredriksen; Ju, Zhenlin; Myrvold, Madeleine; Fasmer, Kristine Eldevik; Halle, Mari Kyllesø; Høivik, Erling Andre; Westin, Shannon; Trovik, Jone; Haldorsen, Ingfrid S.; Mills, Gordon B.; Krakstad, Camilla; Werner, Henrica Maria Johanna (Journal article; Peer reviewed, 2020-02-10)
      Background In endometrioid endometrial cancer (EEC), current clinical algorithms do not accurately predict patients with lymph node metastasis (LNM), leading to both under- and over-treatment. We aimed to develop models ...
    • Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation 

      Karlsson, Thomas; Krakstad, Camilla; Tangen, Ingvild Løberg; Høivik, Erling Andre; Pollock, Pamela M.; Salvesen, Helga; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2017-12-16)
      PTEN loss and constitutive activation of the class I phosphoinositide 3-kinase (PI3K) pathway are key drivers of endometrial tumorigenesis. In some cancer types, PTEN-deficient tumors are reliant on class I PI3K p110β ...
    • Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer 

      Shen, Hui; Fridley, BL; Song, HL; Lawrenson, K; Cunningham, JM; Ramus, SJ; Cicek, MS; Tyrer, J; Stram, D; Larson, MC; Kobel, M; Ziogas, A; Zheng, W; Yang, HP; Wu, AH; Wozniak, EL; Woo, YL; Winterhoff, B; Wik, Elisabeth; Whittemore, AS; Wentzensen, N; Weber, RP; Vitonis, AF; Vincent, D; Vierkant, RA; Vergote, I; Van Den Berg, D; Van Altena, AM; Tworoger, SS; Thompson, PJ; Tessier, DC; Terry, KL; Teo, SH; Templeman, C; Stram, DO; Southey, MC; Sieh, W; Siddiqui, N; Shvetsov, YB; Shu, XO; Shridhar, V; Wang-Gohrke, S; Severi, G; Schwaab, I; Salvesen, Helga Birgitte; Rzepecka, IK; Runnebaum, IB; Rossing, MA; Rodriguez-Rodriguez, L; Risch, HA; Renner, SP; Poole, EM; Pike, MC; Phelan, CM; Pelttari, LM; Pejovic, T; Paul, J; Orlow, I; Omar, SZ; Olson, SH; Odunsi, K; Nickels, S; Nevanlinna, H; Ness, RB; Narod, SA; Nakanishi, T; Moysich, KB; Monteiro, ANA; Moes-Sosnowska, J; Modugno, F; Menon, U; McLaughlin, JR; McGuire, V; Matsuo, K; Adenan, NAM; Massuger, LFAG; Lurie, G; Lundvall, L; Lubinski, J; Lissowska, J; Levine, DA; Leminen, A; Lee, AW; Le, ND; Lambrechts, S; Lambrechts, D; Kupryjanczyk, J; Krakstad, Camilla; Konecny, GE; Kjaer, SK; Kiemeney, LA; Kelemen, LE; Keeney, GL; Karlan, BY; Karevan, R; Kalli, KR; Kajiyama, H; Ji, BT; Jensen, A; Jakubowska, A; Iversen, E; Hosono, S; Hogdall, CK; Hogdall, E; Hoatlin, M; Hillemanns, P; Heitz, F; Hein, R; Harter, P; Halle, Mari Kyllesø; Hall, P; Gronwald, J; Gore, M; Goodman, MT; Giles, GG; Gentry-Maharaj, A; Garcia-Closas, M; Flanagan, JM; Fasching, PA; Ekici, AB; Edwards, R; Eccles, D; Easton, DF; Durst, M; du Bois, A; Dork, T; Doherty, JA; Despierre, E; Dansonka-Mieszkowska, A; Cybulski, C; Cramer, DW; Cook, LS; Chen, XQ; Charbonneau, B; Chang-Claude, J; Campbell, I; Butzow, R; Bunker, CH; Brueggmann, D; Brown, R; Brooks-Wilson, A; Brinton, LA; Bogdanova, N; Block, MS; Benjamin, E; Beesley, J; Beckmann, MW; Bandera, EV; Baglietto, L; Bacot, F; Armasu, SM; Antonenkova, N; Anton-Culver, H; Aben, KK; Liang, D; Wu, XF; Lu, KR; Hildebrandt, MAT; Schildkraut, JM; Sellers, TA; Huntsman, D; Berchuck, A; Chenevix-Trench, G; Gayther, SA; Pharoah, PDP; Laird, PW; Goode, EL; Pearce, CL (Peer reviewed; Journal article, 2013-03-27)
      HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with ...
    • Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC 

      Røsland, Gro Vatne; Dyrstad, Sissel Elisabeth; Tusubira, Deusdedit; Helwa, Reham; Tan, Tuan Zea; Lotsberg, Maria Lie; Pettersen, Ina Katrine Nitschke; Berg, Anna; Kindt, Charlotte; Hoel, Fredrik; Jacobsen, Kristine; Arason, Ari Jon; Engelsen, Agnete; Ditzel, Henrik J.; Lønning, Per Eystein; Krakstad, Camilla; Thiery, Jean Paul; Lorens, James; Knappskog, Stian; Tronstad, Karl Johan (Peer reviewed; Journal article, 2019-06-01)
      Background: Epithelial to mesenchymal transition (EMT) is a well-characterized process of cell plasticity that may involve metabolic rewiring. In cancer, EMT is associated with malignant progression, tumor heterogeneity, ...
    • Expression of L1CAM in curettage or high L1CAM level in preoperative blood samples predicts lymph node metastases and poor outcome in endometrial cancer patients 

      Tangen, Ingvild Løberg; Kopperud, Reidun Kristin; Visser, Nicole C.M.; Staff, Anne Cathrine; Tingulstad, Solveig; Marcickiewicz, Janusz; Amant, Frédéric; Bjørge, Line; Pijnenborg, Johanna M.A.; Salvesen, Helga; Werner, Henrica Maria Johanna; Trovik, Jone; Krakstad, Camilla (Peer reviewed; Journal article, 2017-09)
      Background: Several studies have identified L1 cell adhesion molecule (L1CAM) as a strong prognostic marker in endometrial cancer. To further underline the clinical usefulness of this biomarker, we investigated L1CAM as a ...
    • Feasibility and utility of MRI and dynamic 18F-FDG-PET in an orthotopic organoid-based patient-derived mouse model of endometrial cancer 

      Espedal, Heidi; Berg, Hege Fredriksen; Fonnes, Tina; Fasmer, Kristine Eldevik; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021)
      Background: Pelvic magnetic resonance imaging (MRI) and whole-body positron emission tomography-computed tomography (PET-CT) play an important role at primary diagnostic work-up and in detecting recurrent disease in ...
    • HER2 expression patterns in paired primary and metastatic endometrial cancer lesions 

      Halle, Mari Kyllesø; Tangen, Ingvild Løberg; Berg, Hege Fredriksen; Hoivik, Erling A; Mauland, Karen Klepsland; Kusonmano, Kanthida; Berg, Anna; Hurtado, Antoni; Kalland, Karl-Henning; Øyan, Anne Margrete; Stefansson, Ingunn; Vintermyr, Olav Karsten; Werner, Henrica Maria Johanna; Haldorsen, Ingfrid S.; Trovik, Jone; Salvesen, Helga Birgitte; Krakstad, Camilla (Peer reviewed; Journal article, 2017-11-23)
      Background: Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) receptor in breast and gastric cancers, the potential of HER2 as a therapeutic target in other cancers ...
    • High degree of heterogeneity of PD-L1 and PD-1 from primary to metastatic endometrial cancer 

      Engerud, Hilde Renate; Berg, Hege Fredriksen; Myrvold, Madeleine; Halle, Mari Kyllesø; Bjørge, Line; Haldorsen, Ingfrid S.; Høivik, Erling Andre; Trovik, Jone; Krakstad, Camilla (Journal article; Peer reviewed, 2020)
      Objective PD-L1 and PD-1 are predictive markers for immunotherapy and increasingly relevant in endometrial cancer. The reported fraction of positive primary tumors has been inconsistent. We investigated the expression of ...
    • High visceral fat percentage is associated with poor outcome in endometrial cancer 

      Mauland, Karen Klepsland; Eng, Øyvin Andre Solberg; Ytre-Hauge, Sigmund; Tangen, Ingvild Løberg; Berg, Anna; Salvesen, Helga; Salvesen, Øyvind; Krakstad, Camilla; Trovik, Jone; Høivik, Erling Andre; Werner, Henrica Maria Johanna; Mellgren, Gunnar; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2017-10-19)
      Despite evidence of increased endometrial cancer (EC) risk in obese women, the impact of obesity on clinical and histological phenotype is poorly understood. This study explored abdominal fat volumes and fat distribution ...
    • High-Throughput Mutation Profiling of Primary and Metastatic Endometrial Cancers Identifies KRAS, FGFR2 and PIK3CA to Be Frequently Mutated 

      Krakstad, Camilla; Birkeland, Even; Seidel, Danila; Kusonmano, Kanthida; Petersen, Kjell; Mjøs, Siv; Høivik, Erling Andre; Wik, Elisabeth; Halle, Mari Kyllesø; Øyan, Anne Margrete; Kalland, Karl-Henning; Werner, Henrica Maria Johanna; Trovik, Jone; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2012-12-27)
      Background: Despite being the most common pelvic gynecologic malignancy in industrialized countries, no targeted therapies are available for patients with metastatic endometrial carcinoma. In order to improve treatment, ...