Blar i Bergen Open Research Archive på forfatter "Krause, Maximilian"

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    • CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing 

      Labun, Kornel; Montague, Tessa G.; Krause, Maximilian; Torres Cleuren, Yamila Nicole; Tjeldnes, Håkon; Valen, Eivind (Peer reviewed; Journal article, 2019-07-02)
      The CRISPR–Cas system is a powerful genome editing tool that functions in a diverse array of organisms and cell types. The technology was initially developed to induce targeted mutations in DNA, but CRISPR–Cas has now been ...

    • CRISPR Genome Editing Made Easy Through the CHOPCHOP Website 

      Labun, Kornel; Krause, Maximilian; Torres Cleuren, Yamila Nicole; Valen, Eivind Dale (Journal article; Peer reviewed, 2021)
      The design of optimal guide RNA (gRNA) sequences for CRISPR systems is challenged by the need to achieve highly efficient editing at the desired location (on-target editing) with minimal editing at unintended locations ...

    • Profiling of Small Ribosomal Subunits Reveals Modes and Regulation of Translation Initiation 

      Giess, Adam; Torres Cleuren, Yamila Nicole; Tjeldnes, Håkon; Krause, Maximilian; Bizuayehu, Teshome Tilahun; Hiensch, Senna; Okon, Aniekan; Wagner, Carlston; Valen, Eivind (Journal article; Peer reviewed, 2020)
      Translation initiation is often attributed as the rate-determining step of eukaryotic protein synthesis and key to gene expression control. Despite this centrality, the series of steps involved in this process is poorly ...

    • Reduced α-galactosidase A activity in zebrafish (Danio rerio) mirrors distinct features of Fabry nephropathy phenotype 

      Elsaid, Hassan Osman Alhassan; Furriol, Jessica; Blomqvist, Maria; Diswall, Mette; Leh, Sabine; Gharbi, Naouel; Anonsen, Jan Haug; Babickova, Janka; Tøndel, Camilla; Svarstad, Einar; Marti, Hans Peter; Krause, Maximilian (Journal article; Peer reviewed, 2022)
      Fabry disease (FD) is a rare genetic lysosomal storage disorder, resulting from partial or complete lack of alpha-galactosidase A (α-GAL) enzyme, leading to systemic accumulation of substrate glycosphingolipids with a broad ...

    • TailFindR: Alignment-free poly(A) length measurement for Oxford Nanopore RNA and DNA sequencing 

      Krause, Maximilian; Niazi, Adnan Muhammad; Labun, Kornel; Torres Cleuren, Yamila Nicole; Müller, Florian S; Valen, Eivind (Peer reviewed; Journal article, 2019-07-02)
      Polyadenylation at the 3′-end is a major regulator of messenger RNA and its length is known to affect nuclear export, stability, and translation, among others. Only recently have strategies emerged that allow for genome-wide ...