Blar i Bergen Open Research Archive på forfatter "Kristoffersen, Einar Klæboe"
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Autologous hematopoietic stem cell transplantation for multiple sclerosis: Long-term follow-up data from Norway
Kvistad, Christopher Elnan; Lehmann, Anne Kristine; Stokke, Silje Agnethe; Holmøy, Trygve; Lorentzen, Åslaug Rudjord; Trovik, Linn; Kristoffersen, Einar Klæboe; Bø, Lars; Torkildsen, Øivind (Journal article; Peer reviewed, 2024)Background: Autologous hematopoietic stem cell transplantation (HSCT) is a potent treatment option for patients with aggressive relapsing-remitting multiple sclerosis (RRMS). Objective: To evaluate long-term outcomes ... -
Brief communication: Effects of conditioned media from human platelet lysate cultured MSC on osteogenic cell differentiation in vitro
Shanbhag, Siddharth; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Gruber, Reinhard; Kristoffersen, Einar Klæboe; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2022)Culturing mesenchymal stromal cells (MSC) in human platelet lysate (HPL) supplemented media can enhance their osteogenic differentiation potential. The objective of this study was to test the hypothesis that conditioned ... -
Cold-stored whole blood in a Norwegian emergency helicopter service: an observational study on storage conditions and product quality
Bjerkvig, Christopher Kalhagen; Sivertsen, Joar; Bråthen, Hanne Kristin; Lunde, Turid Helen Felli; Strandenes, Geir; Assmus, Jörg; Hervig, Tor; Cap, Andrew P.; Kristoffersen, Einar Klæboe; Fosse, Theodor; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2020)BACKGROUND Increasing numbers of emergency medical service agencies and hospitals are developing the capability to administer blood products to patients with hemorrhagic shock. Cold‐stored whole blood (WB) is the only ... -
Environmental pollutants in blood donors: The multicentre Norwegian donor study
Averina, Maria; Hervig, Tor; Huber, Sandra; Kjær, Mette; Kristoffersen, Einar Klæboe; Bolann, Bjørn Johan (Journal article; Peer reviewed, 2020)Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood ... -
Functionalizing Collagen Membranes with MSC-Conditioned Media Promotes Guided Bone Regeneration in Rat Calvarial Defects
Shanbhag, Siddharth; Kampleitner, Carina; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Apaza Alccayhuaman, Karol Ali; Heimel, Patrick; Tangl, Stefan; Beinlich, Andreas Michael; Rana, Neha; Sanz, Mariano; Kristoffersen, Einar Klæboe; Mustafa, Kamal Babikeir Elnour; Gruber, Reinhard (Journal article; Peer reviewed, 2023-02-28)Functionalizing biomaterials with conditioned media (CM) from mesenchymal stromal cells (MSC) is a promising strategy for enhancing the outcomes of guided bone regeneration (GBR). This study aimed to evaluate the bone ... -
The immunology of the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; what can the tonsils reveal. A literature review.
Førsvoll, Jostein Andersen; Kristoffersen, Einar Klæboe; Øymar, Knut (Peer reviewed; Journal article, 2020)Objectives: Tonsillectomy (TE) or adenotonsillectomy (ATE) may have a beneficial effect on the clinical course in children with the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. ... -
Immunomodulation induced by stem cell mobilization and harvesting in healthy donors: Increased systemic osteopontin levels after treatment with granulocyte colony-stimulating factor
Melve, Guro Kristin; Ersvær, Elisabeth; Akkøk, Cigdem Ahaein; Ahmed, Aymen B; Kristoffersen, Einar Klæboe; Hervig, Tor; Bruserud, Øystein (Peer reviewed; Journal article, 2016-07-19)Peripheral blood stem cells from healthy donors mobilized by granulocyte colony-stimulating factor (G-CSF) and harvested by leukapheresis are commonly used for allogeneic stem cell transplantation. The frequency of severe ... -
Implementation of a dual platelet inventory in a tertiary hospital during the COVID-19 pandemic enabling cold-stored apheresis platelets for treatment of actively bleeding patients
Braathen, Hanne; Hagen, Kristin Gjerde; Kristoffersen, Einar Klæboe; Strandenes, Geir; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2022)Background: To increase preparedness and mitigate the risk of platelet shortage without increasing the number of collections, we introduced a dual platelet inventory with cold-stored platelets (CSP) with 14-days shelf life ... -
Implementation of a low-titre whole blood transfusion program in a civilian helicopter emergency medical service
Sunde, Geir Arne; Bjerkvig, Christopher Kalhagen; Bekkevold, Marit; Kristoffersen, Einar Klæboe; Strandenes, Geir; Bruserud, Øyvind; Apelseth, Torunn Oveland; Heltne, Jon-Kenneth (Journal article; Peer reviewed, 2022-12-09)Background: Early balanced transfusion is associated with improved outcome in haemorrhagic shock patients. This study describes the implementation and evaluates the safety of a whole blood transfusion program in a civilian ... -
In vitro quality and hemostatic function of cold-stored CPDA-1 whole blood after repeated transient exposure to 28°C storage temperature
Sivertsen, Joar; Hervig, Tor Audun; Strandenes, Geir; Kristoffersen, Einar Klæboe; Braathen, Hanne; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2022)Background Blood products are frequently exposed to room temperature or higher for longer periods than permitted by policy. We aimed to investigate if this resulted in a measurable effect on common quality parameters and ... -
In vitro quality of cold and delayed cold-stored platelet concentrates from interim platelet units during storage for 21 days
Braathen, Hanne; Lunde, Turid Helen Felli; Assmus, Jörg; Hagen, Kristin Gjerde; Kristoffersen, Einar Klæboe; Strandenes, Geir; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2023)Background and Objectives: Based on previous success using apheresis platelets, we wanted to investigate the in vitro quality and platelet function in continuously cold-stored and delayed cold-stored platelet concentrates ... -
Increased infiltration and tolerised antigen-specific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients
Bahador, Marzieh; Gras Navarro, Andrea; Rahman, Mohummad Aminur; Dominguez Valentin, Mev; Sarowar, Shahin; Ulvestad, Elling; Njølstad, Gro; Lie, Stein Atle; Kristoffersen, Einar Klæboe; Bratland, Eirik; Enger, Martha Chekenya (Peer reviewed; Journal article, 2017)Human cytomegalovirus (HCMV) antigens in glioblastoma (GBM) present opportunities for personalised immunotherapy. However, their presence in GBM tissue is still under debate, and evidence of their impact on functional ... -
Novel Nanoparticulate and Ionic Titanium Antigens for Hypersensitivity Testing
Høl, Paul Johan; Kristoffersen, Einar Klæboe; Gjerdet, Nils Roar; Pellowe, Amanda (Peer reviewed; Journal article, 2018-04-06)Titanium is used in a wide variety of materials ranging from medical devices to materials used in everyday life. Adverse biological reactions that could occur in patients, consumers, and workers should be monitored and ... -
Peripheral blood stem cell mobilization in healthy Donors by granulocyte colony-stimulating factor causes preferential mobilization of lymphocyte subsets
Melve, Guro Kristin; Ersvær, Elisabeth; Eide, Geir Egil; Kristoffersen, Einar Klæboe; Bruserud, Øystein (Peer reviewed; Journal article, 2018-05-02)Background: Allogeneic hematopoietic stem cell transplantation is associated with a high risk of immune-mediated post-transplant complications. Graft depletion of immunocompetent cell subsets is regarded as a possible ... -
A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer
Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne; Almås, Bjarte; Børretzen, Astrid; Helle, Svein Inge; Førde, Kristina; Kristoffersen, Einar Klæboe; Kaada, Silje Katrine Helland; Melve, Guro Kristin; Haslerud, Torjan Magne; Biermann, Martin; Bigalke, Iris; Kvalheim, Gunnar; Azeem, Waqas; Olsen, Jan Roger; Gabriel, Benjamin; Knappskog, Stian; Halvorsen, Ole Johan; Akslen, Lars Andreas; Bahn, Duke; Pantel, Klaus; Riethdorf, Sabine; Ragde, Haakon; Gjertsen, Bjørn Tore; Øyan, Anne Margrete; Kalland, Karl Henning; Beisland, Christian (Journal article; Peer reviewed, 2023)Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory ... -
Platelet functionality in cold-stored whole blood
Kristoffersen, Einar Klæboe; Apelseth, Torunn Oveland (Peer reviewed; Journal article, 2019)Whole blood is currently being reintroduced as a blood product to be used in massive bleeding situations because it affords plasma, red cells and platelets in a balanced ratio and in a logistical advantageous way. Questions ... -
Pretreatment of glioblastoma with bortezomib potentiates natural killer cell cytotoxicity through TRAIL/DR5 mediated apoptosis and prolongs animal survival
Gras Navarro, Andrea; Espedal, Heidi; Vareecal Joseph, Justin; Moncho, Laura Trachsel; Bahador, Marzieh; Gjertsen, Bjørn Tore; Kristoffersen, Einar Klæboe; Simonsen, Anne; Miletic, Hrvoje; Enger, Per Øyvind; Rahman, Mohummad Aminur; Enger, Martha Chekenya (Peer reviewed; Journal article, 2019-07-17)Background: Natural killer (NK) cells are potential effectors in anti-cancer immunotherapy; however only a subset potently kills cancer cells. Here, we examined whether pretreatment of glioblastoma (GBM) with the proteasome ... -
Proteomic Analysis of Mesenchymal Stromal Cells Secretome in Comparison to Leukocyte- and Platelet-Rich Fibrin
Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Gruber, Reinhard; Sanz, Mariano; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Kristoffersen, Einar Klæboe; Mustafa, Kamal Babikeir Elnour; Shanbhag, Siddharth (Journal article; Peer reviewed, 2023)Secretomes of mesenchymal stromal cells (MSCs) are emerging as a novel growth factor (GF)-based strategy for periodontal and bone regeneration. The objective of this study was to compare the secretome of human bone marrow ... -
Rekonvalesensplasma mot covid-19 fremstilt fra norske blodgivere
Nissen-Meyer, Lise Sofie Haug; Steinsvåg, Christine Torsvik; Fenstad, Mona H.; Sørvoll, Ingvild Hausberg; Hvalryg, Marte; Titze, Thomas Larsen; Magnussen, Karin; Kristoffersen, Gunn; Johnsen, Kathrine M Neuman; LLOHN, ABID HUSSAIN; Hermundstad, Brita; Høiback, Lilja Synnøve; Haugen, Morten; Kristoffersen, Einar Klæboe; Boulland, Line; Kran, Anne-Marte Bakken; Lund-Johansen, Fridtjof; Vaage, John T.; Flesland, Øystein; Hervig, Tor Audun (Journal article; Peer reviewed, 2023)BAKGRUNN Ved pandemiens start tok Helsedirektoratet og norske blodbanker initiativ til produksjon av covid-19-rekonvalesensplasma innenfor rammen av kliniske studier. Her beskriver vi blodgiverne som deltok. MATERIALE ... -
Thrombocytopaenia in the critically ill
Bruserud, Øyvind; Mosevoll, Knut Anders; Kristoffersen, Einar Klæboe; Kvåle, Reidar; Reikvam, Håkon (Journal article; Peer reviewed, 2021)