Blar i Bergen Open Research Archive på forfatter "Krokengen, Oda Caspara"
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Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice
Ruskamo, Salla; Krokengen, Oda Caspara; Kowal, Julia; Nieminen, Tuomo; Lehtimäki, Mari; Raasakka, Arne; Dandey, Venkata P; Vattulainen, Ilpo; Stahlberg, Henning; Kursula, Petri (Journal article; Peer reviewed, 2020)Myelin protein P2 is a peripheral membrane protein of the fatty acid–binding protein family that functions in the formation and maintenance of the peripheral nerve myelin sheath. Several P2 gene mutations cause human ... -
The intrinsically disordered protein glue of the myelin major dense line: Linking AlphaFold2 predictions to experimental data
Krokengen, Oda Caspara; Raasakka, Arne; Kursula, Petri Tapani (Journal article; Peer reviewed, 2023)Numerous human proteins are classified as intrinsically disordered proteins (IDPs). Due to their physicochemical properties, high-resolution structural information about IDPs is generally lacking. On the other hand, IDPs ... -
Myelin proteins from the peripheral nervous system : Structures and interactions with lipid membrane
Krokengen, Oda Caspara (Doctoral thesis, 2024-08-29)Saltare (å hoppe) beskriver den grunnleggende funksjonen myelin har i nervesystemet. Myelin er en flerlaget fettmembran som omslutter nervecellenes aksoner og effektiviserer signalformidlingen betraktelig ved å øke hastigheten ... -
Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail
Raasakka, Arne; Ruskamo, Salla; Barker, Robert; Krokengen, Oda Caspara; Vatne, Guro Helén; Kristiansen, Cecilie Katrin; Hallin, Erik Ingmar; Skoda, Maximilian W. A.; Bergmann, Ulrich; Wacklin-Knecht, Hanna; Jones, Nykola C; Hoffmann, Søren V; Kursula, Petri (Peer reviewed; Journal article, 2019-06-07)Schwann cells myelinate selected axons in the peripheral nervous system (PNS) and contribute to fast saltatory conduction via the formation of compact myelin, in which water is excluded from between tightly adhered lipid ... -
Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc
Godoy Munoz, Jose Miguel; Neset, Lasse; Markusson, Sigurbjörn; Weber, Sarah; Krokengen, Oda Caspara; Sutinen, Aleksi; Christakou, Eleni; Lopez, Andrea J.; Bramham, Clive Raymond Evjen; Kursula, Petri Tapani (Journal article; Peer reviewed, 2024)The activity-regulated cytoskeleton-associated protein (Arc) is a complex regulator of synaptic plasticity in glutamatergic neurons. Understanding its molecular function is key to elucidate the neurobiology of memory and ... -
Studying lipid interactions of specific myelin proteins using nanoscaled model membrane-mimics and nanoparticles
Krokengen, Oda Caspara (Master thesis, 2018-12-11)The nervous system is a complex and highly specialized network, where rapid conduction of nerve impulses over large distances is required for correct functioning of vertebrate nervous system. Saltatory conduction of ...