Browsing Bergen Open Research Archive by Author "Krug, Norbert"

Now showing items 1-5 of 5

    • Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids 

      Yasinska, Valentyna; Gómez, Cristina; Kolmert, Johan; Ericsson, Magnus; Pohanka, Anton; James, Anna; Andersson, Lars I.; Sparreman-Mikus, Maria; Sousa, Ana R.; Riley, John H.; Bates, Stewart; Bakke, Per S.; Kermani, Nazanin Zounemat; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J.; Geiser, Thomas; Howarth, Peter H.; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Behndig, Annelie; Shaw, Dominick E.; Knowles, Richard G.; Dahlén, Barbro; van der Zee, Anke-Hilse Maitland; Sterk, Peter J.; Djukanovic, Ratko; Adcock, Ian M.; Chung, Kian Fan; Wheelock, Craig E.; Dahlén, Sven-Erik; Jonsson, Eva Wikström (Journal article; Peer reviewed, 2023)
      Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) ...

    • Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation 

      Mikus, Maria Sparreman; Kolmert, Johan; Andersson, Lars I.; Östling, Jörgen; Knowles, Richard G.; Gómez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Khoonsari, Payam Emami; Dahlén, Barbro; Kupczyk, Maciej; de Meulder, Bertrand; Auffray, Charles; Bakke, Per S.; Beghe, Bianca; Bel, Elisabeth H.; Caruso, Massimo; Chanez, Pascal; Chawes, Bo; Fowler, Stephen J.; Gaga, Mina; Geiser, Thomas; Gjomarkaj, Mark; Horváth, Ildikó; Howarth, Peter H.; Johnston, Sebastian L.; Joos, Guy; Krug, Norbert; Montuschi, Paolo; Musial, Jacek; Niżankowska-Mogilnicka, Ewa; Olsson, Henric K.; Papi, Alberto; Rabe, Klaus F.; Sandström, Thomas; Shaw, Dominick E.; Siafakas, Nikolaos M.; Uhlén, Mathias; Riley, John H.; Bates, Stewart; Middelveld, Roelinde J.M.; Wheelock, Craig E.; Chung, Kian Fan; Adcock, Ian M.; Sterk, Peter J.; Djukanovic, Ratko; Nilsson, Peter; Dahlén, Sven-Erik; James, Anna (Journal article; Peer reviewed, 2022)
      Rationale Asthma phenotyping requires novel biomarker discovery. Objectives To identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised ...

    • The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts 

      Hou, Ruihua; Ye, Gang; Cheng, Xiaojing; Shaw, Dominick E.; Bakke, Per S.; Caruso, Massimo; Dahlen, Barbro; Dahlen, Sven-Erik; Fowler, Stephen J.; Horváth, Ildikó; Howarth, Peter; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Auffray, Charles; De Meulder, Bertrand; Sousa, Ana R.; Adcock, Ian M.; Fan Chung, Kian; Sterk, Peter J.; Skipp, Paul J.; Schofield, James; Djukanović, Ratko (Journal article; Peer reviewed, 2023)
      Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the ...

    • Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation: A Clinical Observational Study 

      Kolmert, Johan; Gómez, Cristina; Balgoma, David; Sjödin, Marcus; Bood, Johan; Konradsen, Jon R.; Ericsson, Magnus; Thörngren, John-Olof; James, Anna; Mikus, Maria; Sousa, Ana R.; Riley, John H.; Bates, Stewart; Bakke, Per S.; Pandis, Ioannis; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J.; Geiser, Thomas; Howarth, Peter; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Behndig, Annelie; Shaw, Dominick E.; Knowles, Richard G.; Holweg, Cécile T.J.; Wheelock, Åsa M.; Dahlen, Barbro; Nordlund, Björn; Alving, Kjell; Hedlin, Gunilla; Chung, Kian Fan; Adcock, Ian M.; Sterk, Peter J.; Djukanovic, Ratko; Dahlén, Sven-Erik; Wheelock, Craig E. (Journal article; Peer reviewed, 2021)
      Rationale: New approaches are needed to guide personalized treatment of asthma. Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping. Methods: Urinary metabolites of prostaglandins ...

    • Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study 

      Reinke, Stacey N.; Naz, Shama; Chaleckis, Romanas; Gallart-Ayala, Hector; Kolmert, Johan; Kermani, Nazanin Z.; Tiotiu, Angelica; Broadhurst, David I.; Lundqvist, Anders; Olsson, Henric; Ström, Marika; Wheelock, Åsa M.; Gómez, Cristina; Ericsson, Magnus; Sousa, Ana R.; Riley, John H.; Bates, Stewart; Scholfield, James; Loza, Matthew; Baribaud, Frédéric; Bakke, Per S.; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J.; Geiser, Thomas; Howarth, Peter; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Behndig, Annelie; Singer, Florian; Musial, Jacek; Shaw, Dominick E.; Dahlén, Barbro; Hu, Sile; Lasky-Su, Jessica; Sterk, Peter J.; Chung, Kian Fan; Djukanovic, Ratko; Dahlén, Sven-Erik; Adcock, Ian M.; Wheelock, Craig E. (Journal article; Peer reviewed, 2022)
      Introduction Asthma is a heterogeneous disease with poorly defined phenotypes. Patients with severe asthma often receive multiple treatments including oral corticosteroids (OCS). Treatment may modify the observed metabotype, ...