• Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis 

      Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll; Moitinho-Silva, Lucas; Liwinski, Timur; Zenouzi, Roman; Larsen, Christopher Storm; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Høivik, Marte Lie; Vesterhus, Mette; Trøseid, Marius; Laudes, Matthias; Lieb, Wolfgang; Karlsen, Tom Hemming; Bang, Corinna; Schramm, Christoph; Franke, Andre; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ...
    • Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis 

      Dhillon, Amandeep Kaur; Rupp, Christian; Bergquist, Annika; Voitl, Robert; Folseraas, Trine; Trøseid, Marius; Midttun, Øivind; Ueland, Per Magne; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Kummen, Martin; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background and aims Biomarkers of inflammation may be of clinical utility in primary sclerosing cholangitis (PSC). We aimed to investigate the interferon gamma-related biomarkers neopterin and kynurenine–tryptophanratio ...
    • Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis 

      Dhillon, Amandeep Kaur; Kremer, Andreas E.; Kummen, Martin; Boberg, Kirsten Muri; Elferink, Ronald P. Oude; Karlsen, Tom Hemming; Beuers, Ulrich; Vesterhus, Mette; Hov, Johannes Espolin Roksund (Peer reviewed; Journal article, 2019-06-11)
      Autotaxin has been associated with liver disease severity and transplant-free survival. This study aimed to validate autotaxin as a biomarker in two cohorts of Norwegian large-duct PSC patients, one discovery panel (n=165) ...
    • Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis 

      Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius; Åkra, Sissel; Liaskou, Evaggelia; Moum, Bjørn; Vesterhus, Mette; Karlsen, Tom Hemming; Seljeflot, Ingebjørg; Hov, Johannes Espolin Roksund (Peer reviewed; Journal article, 2019-02)
      Background & Aims: One important hypothesis in primary sclerosing cholangitis pathophysiology suggests that bacterial products from an inflamed leaky gut lead to biliary inflammation. We aimed to investigate whether ...
    • Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency 

      Macpherson, Magnhild Eide; Hov, Johannes Espolin Roksund; Ueland, Thor; Dahl, Tuva Børresdatter; Kummen, Martin; Otterdal, Kari; Holm, Kristian; Berge, Rolf Kristian; Mollnes, Tom Eirik; Trøseid, Marius; Halvorsen, Bente; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Journal article; Peer reviewed, 2020)
      A substantial proportion of patients with common variable immunodeficiency (CVID) have inflammatory and autoimmune complications of unknown etiology. We have previously shown that systemic inflammation in CVID correlates ...
    • Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction 

      Hoel, Hedda Benedicte; Hove-Skovsgaard, Malene; Hov, Johannes Espolin Roksund; Gaardbo, Julie Christine; Holm, Kristian; Kummen, Martin; Rudi, Knut; Nwosu, Felix; Valeur, Jørgen; Gelpi, Marco; Seljeflot, Ingebjørg; Ueland, Per Magne; Gerstoft, Jan; Ullum, Henrik; Aukrust, Pål; Nielsen, Susanne Dam; Trøseid, Marius (Peer reviewed; Journal article, 2018-04-30)
      HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk. We aimed to investigate the combined effect of these diseases on gut microbiota composition ...
    • Low fibre intake is associated with gut microbiota alterations in chronic heart failure 

      Mayerhofer, Cristiane C.K.; Kummen, Martin; Holm, Kristian; Broch, Kaspar; Awoyemi, Ayodeji Olawale; Vestad, Beate; Larsen, Christopher Storm; Seljeflot, Ingebjørg; Ueland, Thor; Bohov, Pavol; Berge, Rolf Kristian; Svardal, Asbjørn M.; Gullestad, Lars; Yndestad, Arne; Aukrust, Pål; Hov, Johannes Espolin Roksund; Trøseid, Marius (Journal article; Peer reviewed, 2020)
      Aims Recent reports have suggested that patients with heart failure (HF) have an altered gut microbiota composition; however, associations with diet remain largely uninvestigated. We aimed to explore differences in the ...
    • NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet 

      Sokolova, Marina; Yang, Kuan; Hansen, Simen Hyll; Louwe, Mieke C.; Kummen, Martin; Hov, Johannes Espolin Roksund; Sjaastad, Ivar; Berge, Rolf Kristian; Halvorsen, Bente; Aukrust, Pål; Yndestad, Arne; Ranheim, Trine (Journal article; Peer reviewed, 2020)
      Obesity-related diseases (e.g. type 2 diabetes mellitus and cardiovascular disorders) represent an increasing health problem worldwide. NLRP3 inflammasome activation may underlie obesity-induced inflammation and insulin ...
    • Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency 

      Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund; Fevang, Børre (Peer reviewed; Journal article, 2019-01-17)
      Common variable immunodefciency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic infammation and ten “key” bacteria ...
    • Rosuvastatin alters the genetic composition of the human gut microbiome 

      Kummen, Martin; Solberg, Ole Geir; Larsen, Christopher Storm; Holm, Kristian; Ragnarsson, Asgrimur; Trøseid, Marius; Vestad, Beate; Skårdal, Rita; Yndestad, Arne; Ueland, Thor; Svardal, Asbjørn M.; Berge, Rolf Kristian; Seljeflot, Ingebjørg; Gullestad, Lars; Karlsen, Tom Hemming; Aaberge, Lars; Aukrust, Pål; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2020)
      The gut microbiome contributes to the variation of blood lipid levels, and secondary bile acids are associated with the effect of statins. Yet, our knowledge of how statins, one of our most common drug groups, affect the ...