Browsing Bergen Open Research Archive by Author "Kursula, Petri Tapani"

Now showing items 1-6 of 6

    • Conformational analysis of membrane-proximal segments of GDAP1 in a lipidic environment using synchrotron radiation suggests a mode of assembly at the mitochondrial outer membrane 

      Sutinen, Aleksi; Jones, Nykola C.; Hoffmann, Søren Vrønning; Ruskamo, Salla; Kursula, Petri Tapani (Journal article; Peer reviewed, 2023)
      The mitochondrial outer membrane creates a diffusion barrier between the cytosol and the mitochondrial intermembrane space, allowing the exchange of metabolic products, important for efficient mitochondrial function in ...

    • Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability 

      Sutinen, Aleksi; Paffenholz, Dirk; Nguyen, Giang Thi Tuyet; Ruskamo, Salla; Torda, Andrew E.; Kursula, Petri Tapani (Journal article; Peer reviewed, 2023)
      Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral polyneuropathy in humans, and its subtypes are linked to mutations in dozens of different genes, including the gene coding for ganglioside-induced ...

    • The intrinsically disordered protein glue of the myelin major dense line: Linking AlphaFold2 predictions to experimental data 

      Krokengen, Oda Caspara; Raasakka, Arne; Kursula, Petri Tapani (Journal article; Peer reviewed, 2023)
      Numerous human proteins are classified as intrinsically disordered proteins (IDPs). Due to their physicochemical properties, high-resolution structural information about IDPs is generally lacking. On the other hand, IDPs ...

    • Protein target highlights in CASP15: Analysis of models by structure providers 

      Alexander, Leila T.; Durairaj, Janani; Kryshtafovych, Andriy; Abriata, Luciano A.; Bayo, Yusupha; Bhabha, Gira; Breyton, Cécile; Caulton, Simon G.; Chen, James; Degroux, Séraphine; Ekiert, Damian C.; Erlandsen, Benedikte S.; Freddolino, Peter L.; Gilzer, Dominic; Greening, Chris; Grimes, Jonathan M.; Grinter, Rhys; Gurusaran, Manickam; Hartmann, Marcus D.; Hitchman, Charlie J.; Keown, Jeremy R.; Kropp, Ashleigh; Kursula, Petri Tapani; Lovering, Andrew L.; Lemaitre, Bruno; Lia, Andrea; Liu, Shiheng; Logotheti, Maria; Lu, Shuze; Markusson, Sigurbjörn; Miller, Mitchell D.; Minasov, George; Niemann, Hartmut H.; Opazo, Felipe; Phillips, George N.; Davies, Owen R.; Rommelaere, Samuel; Rosas-Lemus, Monica; Roversi, Pietro; Satchell, Karla; Smith, Nathan; Wilson, Mark A.; Wu, Kuan-Lin; Xia, Xian; Xiao, Han; Zhang, Wenhua; Zhou, Z. Hong; Fidelis, Krzysztof; Topf, Maya; Moult, John; Schwede, Torsten (Journal article; Peer reviewed, 2023)
      We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively ...

    • Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc 

      Godoy Munoz, Jose Miguel; Neset, Lasse; Markusson, Sigurbjörn; Weber, Sarah; Krokengen, Oda Caspara; Sutinen, Aleksi; Christakou, Eleni; Lopez, Andrea J.; Bramham, Clive Raymond Evjen; Kursula, Petri Tapani (Journal article; Peer reviewed, 2024)
      The activity-regulated cytoskeleton-associated protein (Arc) is a complex regulator of synaptic plasticity in glutamatergic neurons. Understanding its molecular function is key to elucidate the neurobiology of memory and ...

    • Structural properties of the HNF-1A transactivation domain 

      Kind, Laura; Driver, Mark; Raasakka, Arne; Onck, Patrick R.; Njølstad, Pål Rasmus; Arnesen, Thomas; Kursula, Petri Tapani (Journal article; Peer reviewed, 2023)
      Hepatocyte nuclear factor 1α (HNF-1A) is a transcription factor with important gene regulatory roles in pancreatic β-cells. HNF1A gene variants are associated with a monogenic form of diabetes (HNF1A-MODY) or an increased ...