• Anti-HMGB1 auto-Abs influence fatigue in patients with Crohn’s disease 

      Kvivik, Ingeborg; Grimstad, Tore Bjørn; Jonsson, Grete; Kvaløy, Jan T.; Omdal, Roald (Journal article; Peer reviewed, 2021)
      Fatigue is common in all chronic inflammatory and autoimmune diseases. A conceptual model for understanding the biological basis of fatigue describes it as being a part of the sickness behaviour response generated by ...
    • Heat-shock protein 90α in plasma reflects severity of fatigue in patients with Crohn’s disease 

      Grimstad, Tore; Kvivik, Ingeborg; Kvaløy, Jan Terje; Aabakken, Lars; Omdal, Roald (Peer reviewed; Journal article, 2020)
      Heat-shock proteins (HSPs) are evolutionarily conserved proteins with important cellular homeostasis functions during harmful conditions, including inflammation. Some HSPs are secreted extracellularly and act on distant ...
    • Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome 

      Bårdsen, Kjetil; Brede, Cato; Kvivik, Ingeborg; Kvaløy, Jan Terje; Jonsdottir, Kristin; Tjensvoll, Anne Bolette; Ruoff, Peter; Omdal, Roald (Journal article; Peer reviewed, 2019)
      Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ...
    • Neurofilament light is a biomarker of brain involvement in lupus and primary Sjögren’s syndrome 

      Tjensvoll, Anne Bolette; Lauvsnes, Maria Boge; Zetterberg, Henrik; Kvaløy, Jan Terje; Kvivik, Ingeborg; Maroni, Stian; Greve, Ole Jacob; Beyer, Mona K.; Hirohata, Shunsei; Putterman, Chaim; Alves, Guido Werner; Harboe, Erna; Blennow, Kaj; Gøransson, Lasse; Omdal, Roald (Journal article; Peer reviewed, 2020)
      Background To test the hypothesis that neurofilament light (NfL) in CSF is a biomarker of CNS involvement in patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS), we measured NfL in CSF ...
    • Sample Preparation Strategies for Antibody-Free Quantitative Analysis of High Mobility Group Box 1 Protein 

      Kvivik, Ingeborg; Jonsson, Grete; Omdal, Roald; Brede, Cato (Journal article; Peer reviewed, 2021)
      Sickness behavior and fatigue are induced by cerebral mechanisms involving inflammatory cytokines. High mobility group box 1 (HMGB1) is an alarmin, and a potential key player in this process. Reliable quantification methods ...