Browsing Bergen Open Research Archive by Author "Löhr, Iren Høyland"
Now showing items 1-16 of 16
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Co-localization of clinically relevant antibiotic- and heavy metal resistance genes on plasmids in Klebsiella pneumoniae from marine bivalves
Håkonsholm, Fredrik; Hetland, Marit; Löhr, Iren Høyland; Lunestad, Bjørn Tore; Marathe, Nachiket Prakash (Journal article; Peer reviewed, 2023)Klebsiella pneumoniae is an opportunistic pathogen frequently associated with antibiotic resistance and present in a wide range of environments, including marine habitats. However, little is known about the development, ... -
Convergence of virulence and MDR in a single plasmid vector in MDR Klebsiella pneumoniae ST15
Lam, Margaret M.C.; Wyres, Kelly L.; Wick, Ryan R.; Judd, Louise M.; Fostervold, Aasmund; Holt, Kathryn E.; Löhr, Iren Høyland (Peer reviewed; Journal article, 2019)Background: MDR and hypervirulence (hv) are typically observed in separate Klebsiella pneumoniae populations. However, convergent strains with both properties have been documented and potentially pose a high risk to public ... -
Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307
Wyres, Kelly L.; Hawkey, Jane; Hetland, Marit; Fostervold, Aasmund; Wick, Ryan R.; Judd, Louise M.; Hamidian, Mohammad; Howden, Benjamin P.; Löhr, Iren Høyland; Holt, Kathryn E. (Peer reviewed; Journal article, 2019)Objectives: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its ... -
Extended-spectrum β-lactamase producing Klebsiella pneumoniae. A neonatal intensive care unit outbreak, long-term colonization in children and plasmid characteristics
Löhr, Iren Høyland (Doctoral thesis, 2014-12-19)Background: The increasing level of antimicrobial resistance among clinical relevant bacteria, especially the increasing prevalence of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae, is of great concern ... -
The first vanE-type vancomycin resistant Enterococcus faecalis isolates in Norway – phenotypic and molecular characteristics
al Rubaye, Mushtaq Talib Shawi; Janice, Jessin; Bjørnholt, Jørgen; Löhr, Iren Høyland; Sundsfjord, Arnfinn Ståle; Hegstad, Kristin (Journal article; Peer reviewed, 2023)Objectives We aimed to characterize the vanE cluster and its genetic support in the first Norwegian vanE-type isolates and assess genetic relatedness to other vanE isolates. Methods Two vanE-type vancomycin resistant ... -
Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity
Raffelsberger, Niclas Peter; Hetland, Marit Andrea Klokkhammer; Svendsen, Kristian; Småbrekke, Lars; Löhr, Iren Høyland; Andreassen, Lotte; Brisse, Sylvain; Holt, Kathryn E.; Sundsfjord, Arnfinn; Samuelsen, Ørjan; Gravningen, Kirsten Midttun (Journal article; Peer reviewed, 2021)Antibiotic resistant Klebsiella pneumoniae is a leading public health threat and gastrointestinal carriage is an established risk factor for subsequent infections during hospitalization. Our study contributes new knowledge ... -
Highly conserved composite transposon harbouring aerobactin iuc3 in Klebsiella pneumoniae from pigs
Kaspersen, Håkon; Franklin-Alming, Fiona; Hetland, Marit; Bernhoff, Eva; Löhr, Iren Høyland; Jiwakanon, Jatesada; Urdahl, Anne Margrete; Leangapichart, Thongpan; Sunde, Marianne (Journal article; Peer reviewed, 2023)Klebsiella pneumoniae is an important opportunistic pathogen associated with severe invasive disease in humans. Hypervirulent K. pneumoniae, which are K. pneumoniae with several acquired virulence determinants such as the ... -
Insights into the genetic diversity, antibiotic resistance and pathogenic potential of Klebsiella pneumoniae from the Norwegian marine environment using whole-genome analysis
Håkonsholm, Fredrik; Hetland, Marit Andrea Klokkhammer; Svanevik, Cecilie Smith; Lunestad, Bjørn Tore; Löhr, Iren Høyland; Marathe, Nachiket Prakash (Journal article; Peer reviewed, 2022)Klebsiella pneumoniae (Kp) can cause hospital- and community acquired infections. Although, Kp is widespread in the environment, very little is known about the genetic diversity and pathogenicity of Kp from the marine ... -
Long-read sequencing for reliably calling the mompS allele in Legionella pneumophila sequence-based typing
Krøvel, Anne Vatland; Hetland, Marit Andrea Klokkhammer; Bernhoff, Eva; Bjørheim, Anna Steensen; Soma, Markus Andre; Löhr, Iren Høyland (Journal article; Peer reviewed, 2023)Sequence-based typing (SBT) of Legionella pneumophila is a valuable tool in epidemiological studies and outbreak investigations of Legionnaires’ disease. In the L. pneumophila SBT scheme, mompS2 is one of seven genes that ... -
A nationwide genomic study of clinical Klebsiella pneumoniae in Norway 2001–15: introduction and spread of ESBLs facilitated by clonal groups CG15 and CG307
Fostervold, Aasmund; Hetland, Marit Andrea Klokkhammer; Bakksjø, Ragna-Johanne; Bernhoff, Eva; Holt, Kathryn E.; Samuelsen, Ørjan; Simonsen, Gunnar Skov; Sundsfjord, Arnfinn; Wyres, Kelly L.; Löhr, Iren Høyland (Journal article; Peer reviewed, 2022)Objectives To use the nationwide Norwegian surveillance programme on resistant microbes in humans (NORM) to address longitudinal changes in the population structure of Klebsiella pneumoniae isolates from 2001–15, focusing ... -
The Performances of Three Commercially Available Assays for the Detection of SARS‐CoV‐2 Antibodies at Different Time Points Following SARS‐CoV‐2 Infection
Syre, Heidi; Obreque, Marius Eduardo Brå; Dalen, Ingvild; Riis, Åse Garløv; Berg, Åse; Löhr, Iren Høyland; Sundal, Jon; Kleppe, Lars Kåre Selland; Vadla, May Sissel; Lenning, Ole Bernt; Olofsson, Jan Stefan; Mohn, Kristin Greve-Isdahl; Tøndel, Camilla; Blomberg, Bjørn; Trieu, Mai Chi; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2022)The aim of this study was to evaluate the performances of three commercially available antibody assays for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies at different time points ... -
Persistence of a pKPN3-like CTX-M-15-encoding IncFIIK plasmid in a Klebsiella pneumonia ST17 host during two years of intestinal colonization
Löhr, Iren Høyland; Hülter, Nils Fredrik; Bernhoff, Eva; Johnsen, Pål Jarle; Sundsfjord, Arnfinn; Naseer, Mohammed Umaer (Peer reviewed; Journal article, 2015-03-04)Objectives. To characterize the CTX-M-15-encoding plasmid in a Klebsiella pneumoniae ST17 strain, responsible for an outbreak at a Norwegian neonatal intensive care unit and subsequent colonization of affected children for ... -
Population dynamics and characteristics of Klebsiella pneumoniae from healthy poultry in Norway
Kaspersen, Håkon; Urdahl, Anne Margrete; Franklin-Alming, Fiona Valerie; Ilag, Hanna Karin; Hetland, Marit; Bernhoff, Eva; Löhr, Iren Høyland; Sunde, Marianne (Journal article; Peer reviewed, 2023-05-18)Klebsiella pneumoniae is an important opportunistic pathogen widely studied in relation to human infection and colonization. However, there is a lack of knowledge regarding other niches that K. pneumoniae may inhabit. K. ... -
Rapid high-resolution detection of colistin resistance in Gram-negative bacteria using flow cytometry: a comparison with broth microdilution, a commercial screening test and WGS
Ekelund, Oskar; Hetland, Marit Andrea Klokkhammer; Löhr, Iren Høyland; Schön, Thomas; Somajo, Sofia (Journal article; Peer reviewed, 2021)Background Even though both EUCAST and CLSI consider broth microdilution (BMD) as the reference method for antimicrobial susceptibility testing (AST) of colistin, the method exhibits potential flaws related to properties ... -
Use of probiotics to reduce infections and death and prevent colonization with extended-spectrum beta-lactamase (ESBL)- producing bacteria among newborn infants in Tanzania (ProRIDE Trial): study protocol for a randomized controlled clinical trial
Kuwelker, Kanika; Langeland, Nina; Löhr, Iren Høyland; Gidion, Joshua; Manyahi, Joel; Moyo, Sabrina John; Blomberg, Bjørn; Klingenberg, Claus (Journal article; Peer reviewed, 2021)Background Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) has emerged as an urgent global health threat and is by the World Health Organization ranked as priority 1 among pathogens in need of new ... -
Within-patient and global evolutionary dynamics of Klebsiella pneumoniae ST17
Hetland, Marit; Hawkey, Jane; Bernhoff, Eva; Bakksjø, Ragna-Johanne; Kaspersen, Håkon; Rettedal, Siren; Sundsfjord, Arnfinn; Holt, Kathryn E.; Löhr, Iren Høyland (Journal article; Peer reviewed, 2023)Klebsiella pneumoniae sequence type (ST) 17 is a global problem clone that causes multidrug-resistant (MDR) hospital infections worldwide. In 2008–2009, an outbreak of MDR ST17 occurred at a neonatal intensive care unit ...