• Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study 

      Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Nhat Trung, Doan; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Schizophrenia Project (KaSP), Karolinska; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2020)
      Background Schizophrenia (SZ) and bipolar disorder (BD) share substantial neurodevelopmental components affecting brain maturation and architecture. This necessitates a dynamic lifespan perspective in which brain aberrations ...
    • Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder 

      Szabo, Attila; Akkouh, Ibrahim; Ueland, Thor; Lagerberg, Trine Vik; Dieset, Ingrid; Bjella, Thomas; Aukrust, Pål; Le Hellard, Stephanie; Stavrum, Anne-Kristin; Melle, Ingrid; Andreassen, Ole Andreas; Djurovic, Srdjan (Journal article; Peer reviewed, 2020)
      The complex effects of plant cannabinoids on human physiology is not yet fully understood, but include a wide spectrum of effects on immune modulation. The immune system and its inflammatory effector pathways are recently ...
    • Characterisation of age and polarity at onset in bipolar disorder 

      Kalman, Janos L.; Loohuis, Loes M. Olde; Vreeker, Annabel; McQuillin, Andrew; Stahl, Eli A.; Ruderfer, Douglas; Grigoroiu-Serbanescu, Maria; Panagiotaropoulou, Georgia; Ripke, Stephan; Bigdeli, Tim B.; Stein, Frederike; Meller, Tina; Meinert, Susanne; Pelin, Helena; Streit, Fabian; Papiol, Sergi; Adams, Mark J.; Adolfsson, Rolf; Adorjan, Kristina; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Anderson-Schmidt, Heike; Andreassen, Ole Andreas; Ardau, Raffaella; Aubry, Jean-Michel; Balaban, Ceylan; Djurovic, Srdjan; Lagerberg, Trine Vik; Melle, Ingrid; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean (Journal article; Peer reviewed, 2021)
      Background Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening ...
    • Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes 

      O'Connell, Kevin Sean; Frei, Oleksandr; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Cheng, Weiqiu; Chu, Yunhan; Hindley, Guy; Lin, Aihua; Shadrin, Alexey; Barrett, Elizabeth Ann; Lagerberg, Trine Vik; Steen, Nils Eiel; Dale, Anders M.; Djurovic, Srdjan; Andreassen, Ole A. (Journal article; Peer reviewed, 2021)
      Background: A range of sleep disturbances are commonly experienced by patients with psychiatric disorders, and genome-wide genetic analyses have shown some significant genetic correlations between these traits. Here, we ...
    • Composite immune marker scores associated with severe mental disorders and illness course 

      Ormerod, Monica Bettina E. Greenwood; Ueland, Thor; Werner, Maren Caroline Frogner; Hjell, Gabriela; Rødevand, Linn Nilsen; Sæther, Linn Sofie; Lunding, Synve Hoffart; Johansen, Ingrid Torp; Ueland, Torill; Lagerberg, Trine Vik; Melle, Ingrid; Djurovic, Srdjan; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)
      Background Low-grade inflammation has been implicated in the pathophysiology of severe mental disorders (SMDs) and a link between immune activation and clinical characteristics is suggested. However, few studies have ...
    • Early identification of treatment non-response in first-episode psychosis 

      Wold, Kristin Fjelnseth; Ottesen, Akiah; Flaaten, Camilla Bärthel; Johnsen, Erik; Lagerberg, Trine Vik; Romm, Kristin Lie; Simonsen, Carmen; Ueland, Torill; Widing, Line Hustad; Åsbø, Gina; Melle, Ingrid (Journal article; Peer reviewed, 2023)
      Background Approximately one-third of patients with psychotic disorders does not respond to standard antipsychotic treatments. Consensus criteria for treatment resistance (TR) may aid the identification of non-response ...
    • Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes 

      Rødevand, Linn; Bahrami, Shahram; Frei, Oleksandr; Chu, Yunhan; Shadrin, Alexey A.; O'Connell, Kevin S.; Smeland, Olav Bjerkehagen; Elvsåshagen, Torbjørn; Hindley, Guy Frederick Lanyon; Djurovic, Srdjan; Dale, Anders; Lagerberg, Trine Vik; Steen, Nils Eiel; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2021)
      Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD), despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP remain largely unknown. We investigated polygenic ...
    • The genetic architecture of human brainstem structures and their involvement in common brain disorders 

      Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Beyer, Mona K.; Blasi, Giuseppe; Borgwardt, Stefan; Boye, Birgitte; Buitelaar, Jan; Bøen, Erlend; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Coynel, David; di Carlo, Pasquale; Djurovic, Srdjan; Eisenacher, Sarah; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Gelao, Barbara; Harbo, Hanne Flinstad; Hartman, Catharina A.; Håberg, Asta; Heslenfeld, Dirk; Hoekstra, Pieter J.; Høgestøl, Einar August; Jonassen, Rune; Jönsson, Erik G.; Kirsch, Peter; Kloszewska, Iwona; Lagerberg, Trine Vik; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Nordvik, Jan Egil; Nyberg, Lars; O’ Connell, Kevin S.; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin; de Quervain, Dominique; Reif, Andreas; Rokicki, Jaroslav; Van Rooij, Daan; Shadrin, Alexey A.; Schmidt, André; Schwarz, Emanuel; Selbæk, Geir; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar M.; Tsolaki, Magda; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Kaufmann, Tobias (Journal article, 2020)
      Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ...
    • Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients 

      Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine Vik; Steen, Nils Eiel; Ueland, Torill; Andreassen, Ole Andreas; Steen, Vidar Martin; Melle, Ingrid (Peer reviewed; Journal article, 2019-04-27)
      To investigate whether changes in serum lipids are associated with cognitive performance in first episode psychosis (FEP) patients during their first year of antipsychotic drug treatment. One hundred and thirty-two ...
    • Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy 

      Hjell, Gabriela; Rokicki, Jaroslav; Szabo, Attila; Holst, Rene; Tesli, Natalia; Bell, Christina; Fischer-Vieler, Thomas; Werner, Maren Caroline Frogner; Lunding, Synve Hoffart; Elkjær Greenwood Ormerod, Monica Bettina; Johansen, Ingrid Torp; Djurovic, Srdjan; Ueland, Thor; Andreassen, Ole; Melle, Ingrid; Lagerberg, Trine Vik; Mørch-Johnsen, Lynn Egeland; Steen, Nils Eiel; Haukvik, Unn Kristin Hansen (Journal article; Peer reviewed, 2023)
      Background Impulsivity is a transdiagnostic feature linked to severe clinical expression and a potential target for psychopharmacological strategies. Biological underpinnings are largely unknown, but involvement of ...
    • Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis 

      Gjerde, Priyanthi Borgen; Dieset, Ingrid; Simonsen, Carmen Elisabeth; Hoseth, Eva Zsuzsanna; Iversen, Trude Seselie Jahr; Lagerberg, Trine Vik; Lyngstad, Siv Hege; Mørch, Ragni Helene; Skrede, Silje; Andreassen, Ole Andreas; Melle, Ingrid; Steen, Vidar Martin (Peer reviewed; Journal article, 2017-07)
      Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug ...
    • Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation 

      Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål; Boye, Birgitte; Bøen, Erlend; Drange, Ole Kristian; Elvsåshagen, Torbjørn; Engh, John; Hope, Sigrun; Høegh, Margrethe Collier; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Lekva, Tove; Malt, Ulrik Fredrik; Melle, Ingrid; Morken, Gunnar; Nærland, Terje; Steen, Vidar Martin; Sørensen, Kjetil; Wedervang-Resell, Kirsten; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2022)
      Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their ...
    • Inflammation and cognition in severe mental illness: patterns of covariation and subgroups 

      Sæther, Linn Sofie; Ueland, Thor; Haatveit, Beathe; Maglanoc, Luigi; Szabo, Attila; Djurovic, Srdjan; Aukrust, Pål; Roelfs, Daniël; Ormerod, Monica Bettina E. Greenwood; Lagerberg, Trine Vik; Steen, Nils Eiel; Melle, Ingrid; Andreassen, Ole; Ueland, Torill (Journal article; Peer reviewed, 2023)
      A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. ...
    • Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms 

      Rødevand, Linn; Bahrami, Shahram; Frei, Oleksandr; Lin, Aihua; Gani, Osman; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; O'Connell, Kevin; Elvsåshagen, Torbjørn; Winterton, Adriano; Quintana, Daniel; Hindley, Guy Frederick Lanyon; Werner, Maren Caroline Frogner; Djurovic, Srdjan; Dale, Anders Martin; Lagerberg, Trine Vik; Steen, Nils Eiel; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2021)
      Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship ...
    • Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls 

      Engen, Magnus Johan; Lyngstad, Siv Hege; Ueland, Torill; Simonsen, Carmen Elisabeth; Vaskinn, Anja; Smeland, Olav Bjerkehagen; Bettella, Francesco; Lagerberg, Trine Vik; Djurovic, Srdjan; Andreassen, Ole Andreas; Melle, Ingrid (Journal article; Peer reviewed, 2020-11)
      Cognitive impairments are considered core features in schizophrenia and other psychotic disorders. Cognitive impairments are, to a lesser degree, also documented in healthy first-degree relatives. Although recent studies ...
    • Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative 

      Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu; Etain, Bruno; Andreassen, Ole Andreas; Bauer, Michael; Bennabi, Djamila; Blamire, Andrew M.; Boumezbeur, Fawzi; Brambilla, Paolo; Cattane, Nadia; Cattaneo, Annamaria; Chupin, Marie; Coello, Klara; Cointepas, Yann; Colom, Francesc; Cousins, David A.; Dubertret, Caroline; Duchesnay, Edouard; Ferro, Adele; Garcia-Estela, Aitana; Goikolea, Jose; Grigis, Antoine; Haffen, Emmanuel; Høegh, Margrethe Collier; Jakobsen, Petter; Kalman, Janos L.; Kessing, Lars V.; Klohn-Saghatolislam, Farah; Lagerberg, Trine Vik; Landén, Mikael; Lewitzka, Ute; Lutticke, Ashley; Mazer, Nicolas; Mazzelli, Monica; Mora, Cristina; Muller, Thorsten; Mur-Mila, Estanislao; Ødegaard, Ketil Joachim; Oltedal, Leif; Pålsson, Erik; Papadopoulos Orfanos, Dimitri; Papiol, Sergi; Perez-Sola, Victor; Reif, Andreas; Ritter, Philipp; Rossi, Roberto; Schulze, Thomas; Senner, Fanny; Smith, Fiona E.; Squarcina, Letizia; Steen, Nils Eiel; Thelwall, Pete E.; Varo, Cristina; Vieta, Eduard; Vinberg, Maj; Wessa, Michele; Westlye, Lars Tjelta; Bellivier, Frank (Peer reviewed; Journal article, 2019-09-25)
      Background Lithium is recommended as a first line treatment for bipolar disorders. However, only 30% of patients show an optimal outcome and variability in lithium response and tolerability is poorly understood. It remains ...
    • The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis 

      Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Rahman, Zillur; Frei, Oleksandr; Bahrami, Shahram; Shadrin, Alexey; Høegh, Margrethe Collier; Cheng, Weiqiu; Karadag, Naz; Lin, Aihua; Rødevand, Linn; Fan, Chun C.; Djurovic, Srdjan; Lagerberg, Trine Vik; Dale, Anders; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2022)
      Recent genome-wide association studies of mood instability (MOOD) have found significant positive genetic correlation with major depression (DEP) and weak correlations with other psychiatric disorders. We investigated the ...
    • Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation 

      Sheikh, Mashhood Ahmed; O'Connell, Kevin Sean; Lekva, Tove; Szabo, Attila; Akkouh, Ibrahim Ahmed; Osete, Jordi Requena; Agartz, Ingrid; Engh, John; Andreou, Dimitrios; Boye, Birgitte; Bøen, Erlend; Elvsåshagen, Torbjørn; Hope, Sigrun; Werner, Maren Caroline Frogner; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Melle, Ingrid; Drange, Ole Kristian; Morken, Gunnar; Nærland, Terje; Sørensen, Kjetil; Vaaler, Arne; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Aukrust, Pål; Djurovic, Srdjan; Steen, Nils Eiel; Andreassen, Ole; Ueland, Thor (Journal article; Peer reviewed, 2022)
      Background: Cell adhesion molecules (CAMs) orchestrate leukocyte trafficking and could link peripheral and neuroinflammation in patients with severe mental illness (SMI), by promoting inflammatory and immune-mediated ...