Browsing Bergen Open Research Archive by Author "Lagging, Martin"
Now showing items 1-5 of 5
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Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Histopathology in Chronic Hepatitis C Genotype 2 and 3
Rembeck, Karolina; Alsiö, Åsa; Christensen, Peer Brehm; Färkkilä, Martti; Langeland, Nina; Buhl, Mads Rauning; Pedersen, Court; Mørch, Kristine; Westin, Johan; Lindh, Magnus; Hellstrand, Kristoffer; Norkrans, Gunnar; Lagging, Martin (Peer reviewed; Journal article, 2012-01-13)Background and Aims: Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of HCV infection as well as outcome ... -
A novel fibrosis index comprising a non-cholesterol sterol accurately predicts HCV-related liver cirrhosis
Ydreborg, Magdalena; Lisovskaja, Vera; Lagging, Martin; Christensen, Peer Brehm; Langeland, Nina; Buhl, Mads Rauning; Pedersen, Court; Mørch, Kristine; Wejstål, Rune; Norkrans, Gunnar; Lindh, Magnus; Färkkilä, Martti; Westin, Johan (Peer reviewed; Journal article, 2014-04-03)Diagnosis of liver cirrhosis is essential in the management of chronic hepatitis C virus (HCV) infection. Liver biopsy is invasive and thus entails a risk of complications as well as a potential risk of sampling error. ... -
PNPLA 3 I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection
Rembeck, Karolina; Maglio, Cristina; Lagging, Martin; Christensen, Peer Brehm; Färkkilä, Martti; Langeland, Nina; Mørch, Kristine; Buhl, Mads R.; Pedersen, Court; Norkrans, Gunnar; Hellstrand, Kristoffer; Lindh, Magnus; Pirazzi, Carlo; Burza, Maria A.; Romeo, Stefano; Westin, Johan; for the NORDynamIC group (Peer reviewed; Journal article, 2012-09-14)Background: Hepatic steatosis in HCV patients has been postulated as a risk factor associated with a higher frequency of fibrosis and cirrhosis. A single genetic variant, PNPLA3 I148M, has been widely associated with ... -
Presence of interferon-λ 4, male gender, absent/mild steatosis and low viral load augment antibody levels to hepatitis C virus
Waldenström, Jesper; Hellstrand, Kristoffer; Westin, Johan; Nilsson, Staffan; Christensen, Peer; Färkkilä, Martti; Mørch, Kristine; Langeland, Nina; Norkrans, Gunnar; Lagging, Martin (Journal article; Peer reviewed, 2021)Objectives Despite recombinant interferon-λ 4 (IFN-λ4) demonstrating anti-viral activity in vitro and the ancestral functional gene (IFNL4) being conserved in all other primates, there has been speculation that IFN-λ4 may ... -
The relation of 25-hydroxy vitamin D concentrations to liver histopathology, seasonality and baseline characteristics in chronic hepatitis C virus genotype 2 or 3 infection
Waldenström, Jesper; Nyström, Kristina; Nilsson, Staffan; Norkrans, Gunnar; Ydreborg, Magdalena; Langeland, Nina; Mørch, Kristine; Westin, Johan; Lagging, Martin (Journal article; Peer reviewed, 2020)Background and objectives The hydroxylation to 25-hydroxy vitamin D (25(OH)D) occurs in the liver and the impact of liver disease on vitamin D is unclear. This study evaluated the relationship between vitamin D concentrations ...