Blar i Bergen Open Research Archive på forfatter "Landolt, Lea Zoe"
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AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction
Landolt, Lea Zoe; Furriol, Jessica; Babickova, Janka; Ahmed, Lavina; Eikrem, Øystein Solberg; Skogstrand, Trude; Scherer, Andreas; Suliman, Salwa; Leh, Sabine Maria; Lorens, James; Gausdal, Gro; Marti, Hans-Peter; Osman, Tarig Al-Hadi (Peer reviewed; Journal article, 2019)The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial-tomesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL ... -
Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model
Hoel, August; Osman, Tarig; Hoel, Fredrik; Elsaid, Hassan Osman Alhassan; Chen, Tony; Landolt, Lea Zoe; Babickova, Janka; Tronstad, Karl Johan; Lorens, James B.; Gausdal, Gro; Marti, Hans-Peter; Furriol, Jessica (Journal article; Peer reviewed, 2021)Renal fibrosis is a progressive histological manifestation leading to chronic kidney disease (CKD) and associated with mitochondrial dysfunction. In previous work, we showed that Bemcentinib, an Axl receptor tyrosine kinase ... -
Clear cell renal cell carcinoma is linked to epithelial-to-mesenchymal transition and to fibrosis
Landolt, Lea Zoe; Eikrem, Øystein Solberg; Strauss, Philipp; Scherer, Andreas; Lovett, David H.; Beisland, Christian; Finne, Kenneth; Osman, Tarig Al-Hadi; Ibrahim, Mohammad Madani; Gausdal, Gro; Ahmed, Lavina; Lorens, James; Thiery, Jean Paul; Tan, Tuan Zea; Sekulic, Miroslav; Marti, Hans-Peter (Peer reviewed; Journal article, 2017)Clear cell renal cell carcinoma (ccRCC) represents the most common type of kidney cancer with high mortality in its advanced stages. Our study aim was to explore the correlation between tumor epithelial-to-mesenchymal ... -
Epithelial-to-mesenchymal transition in clear cell renal cell cancer and renal fibrosis
Landolt, Lea Zoe (Doctoral thesis, 2019-01-16)Background: Clear cell renal cell cancer (ccRCC) is a common cancer in humans and still has a high mortality. Chronic kidney disease (CKD) is a worldwide public health issue due to its increasing incidence and high morbidity ... -
Expanding the utilization of formalin-fixed, paraffin-embedded archives: Feasibility of miR-Seq for disease exploration and biomarker development from biopsies with clear cell renal cell Carcinoma
Strauss, Philipp; Marti, Hans-Peter; Beisland, Christian; Scherer, Andreas; Lysne, Vegard; Leh, Sabine Maria; Flatberg, Arnar; Koch, Even Evjen; Beisvag, Vidar; Landolt, Lea Zoe; Skogstrand, Trude; Eikrem, Øystein Solberg (Peer reviewed; Journal article, 2018-03-10)Novel predictive tools for clear cell renal cell carcinoma (ccRCC) are urgently needed. MicroRNAs (miRNAs) have been increasingly investigated for their predictive value, and formalin-fixed paraffin-embedded biopsy archives ... -
Transcriptome sequencing (RNAseq) enables utilization of formalin-fixed, paraffin-embedded biopsies with clear cell renal cell carcinoma for exploration of disease biology and biomarker development
Eikrem, Øystein Solberg; Beisland, Christian; Hjelle, Karin Margrethe; Flatberg, Arnar; Scherer, Andreas; Landolt, Lea Zoe; Skogstrand, Trude; Leh, Sabine Maria; Beisvag, Vidar; Marti, Hans-Peter (Peer reviewed; Journal article, 2016-02-22)Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. This proof of concept study aimed to compare RNAseq results from FFPE biopsies with the corresponding RNAlater® (Qiagen, ...