• Age of menarche is associated with knee joint replacement due to primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register) 

      Hellevik, Alf Inge; Nordsletten, Lars; Johnsen, Marianne Bakke; Fenstad, Anne Marie; Furnes, Ove; Storheim, Kjersti; Zwart, John-Anker; Flugsrud, Gunnar B; Langhammer, Arnulf (Peer reviewed; Journal article, 2017-10)
      Objective: To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) ...
    • The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study 

      Johnsen, Marianne Bakke; Vie, Gunnhild Åberge; Winsvold, Bendik K S; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Gabrielsen, Maiken Elvestad; Pedersen, Linda Margareth; Hellevik, Alf Inge; Langhammer, Arnulf; Furnes, Ove; Flugsrud, Gunnar B; Skorpen, Frank; Romundstad, Pål Richard; Storheim, Kjersti; Nordsletten, Lars; Zwart, John-Anker (Peer reviewed; Journal article, 2017-06)
      Objective: Smoking has been associated with a reduced risk of hip and knee osteoarthritis (OA) and subsequent joint replacement. The aim of the present study was to assess whether the observed association is likely to be ...
    • Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations 

      Midttun, Øivind; Theofylaktopoulou, Despoina; Mccann, Adrian; Fanidi, Anouar; Muller, David C.; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao-Ou; Xiang, Yong-Bing; Prentice, Ross; Thomson, Cynthia A.; Pettinger, Mary; Giles, Graham G.; Hodge, Allison; Cai, Qiuyin; Blot, William J.; Wu, Jie; Johansson, Mikael; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Sesso, Howard D.; Gaziano, J. Michael; Buring, Julie E.; Lee, I-Min; Severi, Gianluca; Zhang, Xuehong; Han, Jiali; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Yuan, Jian-Min; Butler, Lesley M.; Koh, Woon-Puay; Wang, Renwei; Gao, Yu-Tang; Ericson, Ulrika; Sonestedt, Emily; Ziegler, Regina G.; Freedman, Neal D.; Visvanathan, Kala; Jones, Miranda R.; Relton, Caroline; Brennan, Paul; Johansson, Mattias; Ueland, Per Magne (Peer reviewed; Journal article, 2017-06)
      Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the ...
    • Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : Nested case-control study within Lung Cancer Cohort Consortium 

      Muller, David C.; Larose, Tricia L; Hodge, Allison; Guida, Florence; Langhammer, Arnulf; Grankvist, Kjell; Meyer, Klaus; Cai, Qiuyin; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Albanes, Demetrius; Giles, Graham G.; Sesso, Howard D.; Lee, I-Min; Gaziano, J. Michael; Yuan, Jian-Min; Hoffman Bolton, Judith; Buring, Julie E.; Visvanathan, Kala; Le Marchand, Loic; Purdue, Mark P.; Caporaso, Neil E.; Midttun, Øivind; Ueland, Per Magne; Prentice, Ross L.; Weinstein, Stephanie J.; Stevens, Victoria L.; Zheng, Wei; Blot, William J.; Shu, Xiao-Ou; Zhang, Xuehong; Xiang, Yong-Bing; Koh, Woon-Puay; Hveem, Kristian; Thomson, Cynthia A.; Pettinger, Mary; Engström, Gunnar; Brunnström, Hans; Milne, Roger L.; Stampfer, Meir J.; Han, Jiali; Johansson, Mikael; Brennan, Paul; Severi, Gianluca; Johansson, Mattias (Peer reviewed; Journal article, 2019-01-03)
      Objectives: Inflammation may play an important role in lung cancer pathogenesis. Previous studies have suggested an association between C-reactive protein (CRP) as a marker of inflammation, and risk of lung cancer, but ...
    • Global Lung Function Initiative 2012 reference equations for spirometry in the Norwegian Population 

      Langhammer, Arnulf; Johannessen, Ane; Holmen, Turid Lingaas; Melbye, Hasse; Stanojevic, Sanja; Lund, May Brit; Melsom, Morten Nissen; Bakke, Per S.; Quanjer, Philip (Peer reviewed; Journal article, 2016)
      We studied the fit of the Global Lung Function Initiative (GLI) all-age reference values to Norwegians, compared them with currently used references (European Community for Steel and Coal (ECSC) and Zapletal) and estimated ...
    • Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study) 

      Hellevik, Alf Inge; Johnsen, Marianne Bakke; Langhammer, Arnulf; Fenstad, Anne Marie; Furnes, Ove; Storheim, Kjersti; Zwart, John-Anker; Flugsrud, Gunnar B; Nordsletten, Lars (Peer reviewed; Journal article, 2017-05-18)
      Background: To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis. Methods: In a prospective cohort study, data from the second and third survey of the ...
    • Is there an Association between vitamin D status and risk of chronic low back pain? A nested case-Control analysis in the Nord-Trøndelag Health Study 

      Heuch, Ingrid; Heuch, Ivar; Hagen, Knut; Mai, Xiao-Mei; Langhammer, Arnulf; Zwart, John-Anker (Peer reviewed; Journal article, 2017-11-25)
      Objectives: To explore potential associations between vitamin D status and risk of chronic low back pain (LBP) in a Norwegian cohort, and to investigate whether relationships depend on the season of blood sample collection. ...
    • Large-scale external validation and comparison of prognostic models: An application to chronic obstructive pulmonary disease 

      Guerra, Beniamino; Haile, Sarah R.; Lamprecht, Bernd; Ramírez, Ana S.; Martinez-Camblor, Pablo; Kaiser, Bernhard; Alfageme, Inmaculada; Almagro, Pere; Casanova, Ciro; Esteban-González, Cristóbal; Soler-Cataluña, Juan J.; de-Torres, Juan P.; Miravitlles, Marc; Celli, Bartolomé R.; Marin, Jose M.; ter Riet, Gerben; Sobradillo, Patricia; Lange, Peter; Garcia-Aymerich, Judith; Antó, Jósep Maria; Turner, Alice M.; Han, Meilan K.; Langhammer, Arnulf; Leivseth, Linda; Bakke, Per S.; Johannessen, Ane; Oga, Toru; Cosio, Borja; Ancochea-Bermúdez, Julio; Echazarreta, Andrés; Roche, Nicolas; Burgel, Pierre-Régis; Sin, Don D.; Soriano, Joan B.; Puhan, Milo A. (Peer reviewed; Journal article, 2018-03-02)
      Background: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease ...
    • The mediating effect of body mass index on the relationship between smoking and hip or knee replacement due to primary osteoarthritis. A population-based cohort study (the HUNT study) 

      Johnsen, Marianne Bakke; Hellevik, Alf Inge; Småstuen, Milada C; Langhammer, Arnulf; Furnes, Ove; Flugsrud, Gunnar B; Nordsletten, Lars; Zwart, John-Anker; Storheim, Kjersti (Peer reviewed; Journal article, 2017-12-28)
      To investigate the total effect of smoking on total hip or knee replacement (THR/TKR) due to primary osteoarthritis (OA) and to quantify the indirect effect of smoking through body mass index (BMI). Participants from the ...
    • Metabolic syndrome as a risk factor for total hip or knee replacement due to primary osteoarthritis: A prospective cohort study (the HUNT study and the Norwegian arthroplasty register) 

      Hellevik, Alf Inge; Johnsen, Marianne Bakke; Langhammer, Arnulf; Baste, Valborg; Furnes, Ove; Storheim, Kjersti; Zwart, John-Anker; Flugsrud, Gunnar B; Nordsletten, Lars (Peer reviewed; Journal article, 2018-01-10)
      Objective: Biochemical changes associated with obesity may accelerate osteoarthritis beyond the effect of mechanical factors. This study investigated whether metabolic syndrome and its components (visceral obesity, ...
    • Prevalence of, and work-related risk factors for, hand eczema in a Norwegian general population (The HUNT Study) 

      Vindenes, Hilde Kristin; Svanes, Cecilie; Lygre, Stein Håkon Låstad; Hollund, Bjørg Eli; Langhammer, Arnulf; Bertelsen, Randi Jacobsen (Peer reviewed; Journal article, 2017-10)
      Background: Chemical exposures at work and at home may cause hand eczema. However, this has been scarcely described for Norway. Objectives: To investigate the prevalence of, and occupational risk factors for, hand eczema ...
    • A simple algorithm for the identification of clinical COPD phenotypes 

      Burgel, Pierre-Régis; Paillasseur, Jean-Louis; Janssens, Wim; Piquet, Jacques; Ter Riet, Gerben; Garcia-Aymerich, Judith; Cosio, Borja; Bakke, Per S.; Puhan, Milo A.; Langhammer, Arnulf; Alfageme, Inmaculada; Almagro, Pere; Ancochea, Julio; Celli, Bartolomé R.; Casanova, Ciro; de-Torres, Juan P.; Decramer, Marc; Echazarreta, Andrés; Esteban, Cristobal; Punter, Rosa Mar Gomez; Han, Meilan K.; Johannessen, Ane; Kaiser, Bernhard; Lamprecht, Bernd; Lange, Peter; Leivseth, Linda; Marin, Jose M.; Martin, Francis; Martinez-Camblor, Pablo; Miravitlles, Marc; Oga, Toru; Ramírez, Ana Sofia; Sin, Don D.; Sobradillo, Patricia; Soler-Cataluña, Juan J.; Turner, Alice M.; Rivera, Francisco Javier Verdu; Soriano, Joan B.; Roche, Nicolas (Peer reviewed; Journal article, 2017)
      This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses. Data from 2409 COPD patients of French/Belgian COPD ...
    • Vitamin B6 catabolism and lung cancer risk: Results from the Lung Cancer Cohort Consortium (LC3) 

      Zuo, Hui; Ueland, Per Magne; Midttun, Øivind; Tell, Grethe S.; Fanidi, Anouar; Zheng, Wei; Shu, Xiao-Ou; Xiang, Yong-Bing; Wu, Jie; Prentice, Ross L.; Pettinger, Mary; Thomson, Cynthia A.; Giles, Graham G.; Hodge, Allison M.; Cai, Qiuyin; Blot, William J.; Johansson, Mikael B.; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Ziegler, Regina G.; Freedman, Neal David; Caporaso, Neil E.; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Buring, Julie E.; Lee, I-Min; Gaziano, John Michael; Severi, Gianluca; Zhang, Xuehong; Stampfer, Meir Jonathan; Han, Jiali; Zeleniuch-Jacquotte, Anne; Marchand, Loïc Le; Yuan, Jian-Min; Wang, Renwei; Koh, Woon-Puay; Gao, Yutang; Ericson, Ulrika C.; Visvanathan, Kala; Jones, Michael R.; Relton, Caroline Laura; Brennan, Paul J.; Johansson, Mattias; Ulvik, Arve (Journal article; Peer reviewed, 2019-03)
      Background Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal-5'-phosphate), has been positively associated with ...