Blar i Bergen Open Research Archive på forfatter "Larsen, Alf Inge"
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The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication
Brügger-Andersen, Trygve; Bostad, Leif; Sandnes, Dagny A.; Larsen, Alf Inge; Bonarjee, Vernon V. S.; Barvik, Ståle; Melberg, Tor; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2010-01-27)Background The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation ... -
Automatic Estimation of Coronary Blood Flow Velocity Step 1 for Developing a Tool to Diagnose Patients With Micro-Vascular Angina Pectoris
Khanmohammadi, Mahdieh; Sæland, Charlotte; Engan, Kjersti; Eftestøl, Trygve Christian; Larsen, Alf Inge (Peer reviewed; Journal article, 2019-01-22)Aim: Our aim was to automatically estimate the blood velocity in coronary arteries using cine X-ray angiographic sequence. Estimating the coronary blood velocity is a key approach in investigating patients with angina ... -
Blood Lactate AUC Is a Sensitive Test for Evaluating the Effect of Exercise Training on Functional Work Capacity in Patients with Chronic Heart Failure
Valborgland, Torstein; Isaksen, Kjetil; Munk, Peter Scott; Larsen, Alf Inge (Journal article; Peer reviewed, 2021)Purpose. Exercise training is an essential treatment option for patients with chronic heart failure (CHF). However, it remains controversial, which surrogate measures of functional work capacity are most reliable. The ... -
Burden of treatment in patients with chronic heart failure – A cross-sectional study
Nordfonn, Oda Karin; Morken, Ingvild Margreta; Bru, Lars Edvin; Larsen, Alf Inge; Husebø, Anne Marie Lunde (Journal article; Peer reviewed, 2021)Background Patients with heart failure (HF) must manage both a demanding treatment regimen and self-care, which may lead to a burden of treatment. The purpose of this study was to assess the levels of burdens from treatment ... -
Cardiac arrest as a reportable condition: A cohort study of the first 6 years of the Norwegian out-of-hospital cardiac arrest registry
Tjelmeland Myrhaugen, Ingvild Beathe; Alm-Kruse, Kristin; Andersson, Lars-Jøran; Bratland, Ståle; Hafstad, Arne Ketil; Haug, Bjørn; Langørgen, Jørund; Larsen, Alf Inge; Lindner, Thomas Werner; Nilsen, Jan Erik; Olasveengen, Theresa Mariero; Søreide, Eldar; Skogvoll, Eirik; Kramer-Johansen, Jo (Journal article; Peer reviewed, 2020)Objectives The Norwegian Cardiac Arrest Registry (NorCAR) was established in 2013 when cardiac arrest became a mandatory reportable condition. The aim of this cohort study is to describe how the world’s first mandatory, ... -
Effects of anthocyanin supplementation on serum lipids, glucose, markers of inflammation and cognition in adults with increased risk of dementia - A pilot study
Bergland, Anne Katrine; Sønnesyn, Hogne; Dalen, Ingvild; Rodriguez-Mateos, Ana; Berge, Rolf Kristian; Melvær, Giil Lasse; Rajendran, Lawrence; Siow, Richard; Tassotti, Michele; Larsen, Alf Inge; Aarsland, Dag (Peer reviewed; Journal article, 2019-06-11)Background: Anthocyanins may protect against cardiovascular related cognitive decline and dementia. Objective: Open-label study to measure changes in serum lipids, glucose, glycosylated hemoglobin (HbA1c), and markers of ... -
Effects of interval training on inflammatory biomarkers in patients with ischemic heart failure
Isaksen, Kjetil; Halvorsen, Bente; Munk, Peter Scott; Aukrust, Pål; Larsen, Alf Inge (Peer reviewed; Journal article, 2019)Objectives. Exercise training has been proposed to have anti-inflammatory effects. We examined whether aerobic interval training (AIT) can attenuate the inflammatory response in ischemic heart failure (HF) as measured by ... -
Effects of purified anthocyanins in people at risk for dementia: Study protocol for a phase II randomized controlled trial
Khalifa, Khadija; Bergland, Anne Katrine; Sønnesyn, Hogne; Oppedal, Ketil; Oesterhus, Ragnhild; Dalen, Ingvild; Larsen, Alf Inge; Fladby, Tormod; Brooker, Helen; Wesnes, Keith A.; Ballard, Clive; Aarsland, Dag (Journal article; Peer reviewed, 2020)Background: The number of people with dementia is increasing, with huge challenges for society and health-care systems. There are no disease-modifying therapies available. There is, therefore, an urgent need to identify ... -
Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction
Koppen, Elias; Omland, Torbjørn; Larsen, Alf Inge; Karlsen, Trine; Linke, Axel; Prescott, Eva Irene Bossano; Halle, Martin; Dalen, Håvard; Delagardelle, Charles; Hole, Torstein; van Craenenbroeck, Emeline M.; Beckers, Paul; Ellingsen, Øyvind; Feiereisen, Patrick; Valborgland, Torstein; Videm, Vibeke (Journal article; Peer reviewed, 2021)Aims Whether an exercise training intervention is associated with reduction in long-term high-sensitivity cardiac troponin T (hs-cTnT) concentration (a biomarker of subclinical myocardial injury) in patients with heart ... -
Factors predicting the use of therapeutic hypothermia and survival in unconscious out-of-hospital cardiac arrest patients admitted to the ICU
Lindner, Thomas Werner; Langørgen, Jørund; Sunde, Kjetil; Larsen, Alf Inge; Kvaløy, Jan Terje; Heltne, Jon-Kenneth; Drægni, Tomas; Søreide, Eldar (Peer reviewed; Journal article, 2013-07-23)Introduction: Therapeutic hypothermia (TH) after out-of-hospital cardiac arrest (OHCA) was adopted early in Norway. Since 2004 the general recommendation has been to cool all unconscious OHCA patients treated in the intensive ... -
High-Intensity Interval Training in Patients with Heart Failure with Reduced Ejection Fraction
Ellingsen, Øyvind; Halle, Martin; Conraads, Viviane; Støylen, Asbjørn; Dalen, Håvard; Delagardelle, Charles; Larsen, Alf Inge; Hole, Torstein; Mezzani, Alessandro; Van Craenenbroeck, Emeline M.; Videm, Vibeke; Beckers, Paul; Christle, Jeffrey W.; Winzer, Ephraim; Mangner, Norman; Woitek, Felix; Höllriegel, Robert; Pressler, Axel; Monk-Hansen, Tea; Snoer, Martin; Feiereisen, Patrick; Valborgland, Torstein; Kjekshus, John; Hambrecht, Rainer; Gielen, Stephan; Karlsen, Trine; Prescott, Eva; Linke, Axel (Peer reviewed; Journal article, 2017-02)Background: Small studies have suggested that high-intensity interval training (HIIT) is superior to moderate continuous training (MCT) in reversing cardiac remodeling and increasing aerobic capacity in patients with heart ... -
A history of late and very late stent thrombosis is not associated with increased activation of the contact system, a case control study
Pönitz, Volker; Govers-Riemslag, José W.; Cate, Hugo ten; Oerle, Rene van; Brügger-Andersen, Trygve; Grundt, Heidi; Næsgaard, Patrycja A.; Pritchard, David; Larsen, Alf Inge; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2010-04-15)Background: The pathophysiological pathways resulting in Late Stent Thrombosis (LST) remain uncertain. Findings from animal studies indicate a role of the intrinsic coagulation pathway in arterial thrombus formation, while ... -
The Localization and Characterization of Ischemic Scars in relation to the Infarct Related Coronary Artery Assessed by Cardiac Magnetic Resonance and a Novel Automatic Postprocessing Method
Woie, Leik; Engan, Kjersti; Eftestøl, Trygve; Larsen, Alf Inge; Ørn, Stein (Peer reviewed; Journal article, 2015)Aims. The correspondence between the localization and morphology of ischemic scars and the infarct related artery (IRA) by use of cardiac magnetic resonance imaging and a novel automatic postprocessing method. Methods and ... -
Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size
Butt, Noreen; Bache-Mathiesen, Lena Kristin; Ushakova, Anastasia; Nordrehaug, Jan Erik; Jensen, Senn-Erik; Munk, Peter Scott; Danchin, N; Dubois-Rande, Jean-Luc; Hansen, HS; Paganelli, F; Le Corvoisier, P; Firat, H; Erlinge, David; Atar, Dan; Larsen, Alf Inge (Journal article; Peer reviewed, 2020)Background: The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic ... -
Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study
Pettersen, Trond Røed; Schjøtt, Jan Didrik; Allore, Heather G; Bendz, Bjørn; Borregaard, Britt; Fridlund, Bengt Gotthard Anton; Larsen, Alf Inge; Nordrehaug, Jan Erik; Rotevatn, Svein; Wentzel-Larsen, Tore; Norekvål, Tone Merete (Journal article; Peer reviewed, 2022)Objective: To determine patient perceptions of generic medicines 2 and 6 months after percutaneous coronary intervention (PCI), and to determine whether these perceptions moderate medication adherence. Design: Prospective ... -
Plasma tumour necrosis factor correlates with mRNA expression of tumour necrosis factor and mitochondrial transcription factors in skeletal muscle in patients with chronic heart failure treated with cardiac resynchronization therapy: potential role in myopathy
Larsen, Alf Inge; Valborgland, Torstein; Ogne, Christer; Lindal, Sigurd; Halvorsen, Bente; Munk, Peter Scott; Kvaløy, Jan Terje; Aukrust, Pål; Yndestad, Arne (Peer reviewed; Journal article, 2019)Chronic heart failure (CHF) is characterized by inflammation and skeletal muscle myopathy, including impaired fibre type distribution and reduced capillary density, reduced cytochrome oxidase activity and reduced mitochondrial ... -
Post resuscitation care – some words of caution and a call for action
Søreide, Eldar; Larsen, Alf Inge (Journal article, 2015-11-04)This fall the European Resuscitation Council (ERC) and the European Cardiology Society (ESC) publish updated post resuscitation care guidelines. For these guidelines to have an impact they must be implemented into daily ... -
QRS fragmentation is associated with increased risk of ventricular arrhythmias in high-risk patients; Data from the SMASH 1 Study
Sourour, Nur; Riveland, Egil Aarstad; Rømo, Terje; Næsgaard, Patrycja; Kjekshus, Harald; Larsen, Alf Inge; Omland, Torbjørn; Røsjø, Helge Rørvik; Myhre, Peder Langeland (Journal article; Peer reviewed, 2022)Introduction QRS fragmentation (fQRS), defined as the presence of additional spikes within the QRS complex, has been associated with myocardial conduction abnormalities and arrhythmogenicity. Objective We aimed to ... -
Rationale and design of the PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA II) trial: a randomized, placebo-controlled, multicenter trial
Mecinaj, Albulena; Gulati, Geeta; Heck, Siri Lagethon; Holte, Espen; Fagerland, Morten Wang; Larsen, Alf Inge; Blix, Egil Støre; Geisler, Jürgen; Wethal, Torgeir; Omland, Torbjørn (Journal article, 2021)Background: Recent advances in the treatment algorithms of early breast cancer have markedly improved overall survival. However, anthracycline- and trastuzumab-associated cardiotoxicity may lead to dose-reduction or halt ... -
Rethinking rehabilitation after percutaneous coronary intervention: a protocol of a multicentre cohort study on continuity of care, health literacy, adherence and costs at all care levels (the CONCARDPCI)
Norekvål, Tone Merete; Allore, Heather G; Bendz, Bjørn; Bjorvatn, Cathrine; Borregaard, Britt; Brørs, Gunhild; Deaton, Christi; Fålun, Nina Britt; Hadjistavropoulos, Heather; Hansen, Tina Birgitte; Igland, Stig; Larsen, Alf Inge; Palm, Pernille; Pettersen, Trond Røed; Rasmussen, Trine Bernholdt; Schjøtt, Jan; Søgaard, Rikke; Valaker, Irene; Zwisler, Ann Dorthe; Rotevatn, Svein (Journal article; Peer reviewed, 2020)Introduction Percutaneous coronary intervention (PCI) aims to provide instant relief of symptoms, and improve functional capacity and prognosis in patients with coronary artery disease. Although patients may experience ...