• Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat 

      Hole, Lisa Drange; Larsen, Terje H.; Fossan, Kjell Ove; Limé, Fredrik; Schjøtt, Jan (Peer reviewed; Journal article, 2014-05-27)
      Aim: Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In this study we wanted to investigate ...
    • Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat 

      Hole, Lisa Drange; Larsen, Terje H.; Fossan, Kjell Ove; Limé, Fredrik; Schjøtt, Jan (Peer reviewed; Journal article, 2014-05-27)
      Aim: Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In this study we wanted to investigate ...
    • Giant right ventricular outflow tract thrombus in hereditary spherocytosis: a case report 

      Davidsen, Cedric; Larsen, Terje H.; Gerdts, Eva; Lønnebakken, Mai Tone (Peer reviewed; Journal article, 2016-04-26)
      Background: In hereditary spherocytosis with severe anemia, splenectomy is a recommended treatment. However, the spleen carries an important role both in immune function and coagulation. The increased risk of bacterial ...
    • Morphine enhances doxorubicin-induced cardiotoxicity in the rat 

      Hole, Lisa Drange; Larsen, Terje H.; Fossan, Kjell Ove; Limé, Fredrik; Schjøtt, Jan (Peer reviewed; Journal article, 2014-09)
      Interventions to reduce the cardiotoxicity of doxorubicin are clinically relevant. Pharmacological preconditioning mimicking ischemic preconditioning has been demonstrated with morphine and represents an acceptable clinical ...
    • The Norwegian Stroke in the Young Study (NOR-SYS): rationale and design 

      Fromm, Annette; Thomassen, Lars; Næss, Halvor; Meijer, Rudy; Eide, Geir Egil; Kråkenes, Jostein; Vedeler, Christian A.; Gerdts, Eva; Larsen, Terje H.; Kuiper, Karel Kier-Jan; Laxdal, Elin Hanna; Russell, David; Tatlisumak, Turgut; Waje-Andreassen, Ulrike (Peer reviewed; Journal article, 2013-07-17)
      Background: Ischemic stroke in young adults is a major health problem being associated with a higher vascular morbidity and mortality compared to controls, and a stroke recurrence rate of 25% during the first decade. The ...
    • A short-time model to study relevant indices of cardiotoxicity of doxorubicin in the rat 

      Hole, Lisa Drange; Larsen, Terje H.; Fossan, Kjell Ove; Limé, Fredrik; Schjøtt, Jan (Peer reviewed; Journal article, 2013-07)
      Aim: Short-time models (STM) to study the cardiotoxicity (acute or chronic) of doxorubicin in rats are of interest to assess protective interventions and pathways. STM promotes more ethical animal treatment with less stress, ...