Blar i Bergen Open Research Archive på forfatter "Laulumaa, Saara"
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Determinants of ligand binding and catalytic activity in the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase
Raasakka, Arne; Myllykoski, Matti; Laulumaa, Saara; Lehtimäki, Mari; Härtlein, Michael; Moulin, Martine; Kursula, Inari; Kursula, Petri (Peer reviewed; Journal article, 2015-11-13)2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) is an enzyme highly abundant in the central nervous system myelin of terrestrial vertebrates. The catalytic domain of CNPase belongs to the 2H phosphoesterase superfamily ... -
Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants
Uusitalo, Maiju; Klenow, Martin Berg; Laulumaa, Saara; Blakeley, Matthew P.; Simonsen, Adam Cohen; Ruskamo, Salla; Kursula, Petri (Journal article; Peer reviewed, 2021)Peripheral myelin protein 2 (P2) is a fatty acid-binding protein expressed in vertebrate peripheral nervous system myelin, as well as in human astrocytes. Suggested functions of P2 include membrane stacking and lipid ... -
Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins
Laulumaa, Saara; Nieminen, Tuomo; Raasakka, Arne; Krokengen, Oda C.; Safaryan, Anushik; Hallin, Erik Ingmar; Brysbaert, Guillaume; Lensink, Marc F.; Ruskamo, Salla; Vattulainen, Ilpo; Kursula, Petri (Peer reviewed; Journal article, 2018-06-25)Background: Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-specific ... -
Sub-atomic resolution crystal structures reveal conserved geometric outliers at functional sites
Laulumaa, Saara; Kursula, Petri (Peer reviewed; Journal article, 2019-08-22)Myelin protein 2 (P2) is a peripheral membrane protein of the vertebrate nervous system myelin sheath, having possible roles in both lipid transport and 3D molecular organization of the multilayered myelin membrane. We ... -
Sub-atomic resolution crystal structures reveal conserved geometric outliers at functional sites
Laulumaa, Saara; Kursula, Petri (Peer reviewed; Journal article, 2019-08-22)Myelin protein 2 (P2) is a peripheral membrane protein of the vertebrate nervous system myelin sheath, having possible roles in both lipid transport and 3D molecular organization of the multilayered myelin membrane. We ...