Browsing Bergen Open Research Archive by Author "Lee-Ødegård, Sindre"

Now showing items 1-3 of 3

    • Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array 

      Lee, Yunsung; Løkås Haftorn, Kristine; Denault, William Robert Paul; Nustad, Haakon Egdetveit; Page, Christian; Moen, Gunn-Helen; Magnus, Maria C.; Gjessing, Håkon K.; Harris, Jennifer R.; Magnus, Per; Håberg, Siri E.; Jugessur, Astanand; Bohlin, Jon; Lyle, Robert; Lee-Ødegård, Sindre; Groop, Leif C.; Prasad, Rashmi B.; Sletner, Line; Sommer, Christine (Journal article; Peer reviewed, 2020)
      Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina ...

    • DNA methylation risk score for type 2 diabetes is associated with gestational diabetes 

      Linares-Pineda, Teresa M.; Fragoso Bargas, Nicolas; Picón, María José; Molina-Vega, Maria; Jenum, Anne Karen; Sletner, Line; Lee-Ødegård, Sindre; Opsahl, Julia Onsrud; Moen, Gunn-Helen; Qvigstad, Elisabeth; Prasad, Rashmi B.; Birkeland, Kåre Inge; Morcillo, Sonsoles; Sommer, Christine (Journal article; Peer reviewed, 2024-02-13)
      Background: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a ...

    • Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism 

      Jersin, Regine Åsen; Tallapragada, Divya Sri; Skartveit, Linn; Bjune, Mona Synnøve; Muniandy, Maheswary; Lee-Ødegård, Sindre; Heinonen, Sini; Alvarez, Marcus; Birkeland, Kåre Inge; Drevon, Christian André; Pajukanta, Päivi; McCann, Adrian; Pietiläinen, Kirsi H.; Claussnitzer, Melina; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2023)
      Context The neutral amino acid transporter SLC7A10/ASC-1 is an adipocyte-expressed gene with reduced expression in insulin resistance and obesity. Inhibition of SLC7A10 in adipocytes was shown to increase lipid accumulation ...