Browsing Bergen Open Research Archive by Author "Leh, Sabine"
Now showing items 1-17 of 17
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Best Practice Recommendations for the Implementation of a Digital Pathology Workflow in the Anatomic Pathology Laboratory by the European Society of Digital and Integrative Pathology (ESDIP)
Fraggetta, Filippo; L'Imperio, Vincenzo; Ameisen, David; Carvalho, Rita; Leh, Sabine; Kiehl, Tim-Rasmus; Serbanescu, Mircea; Racoceanu, Daniel; Mea, Vincenzo Della; Polonia, Antonio; Zerbe, Norman; Eloy, Catarina (Journal article; Peer reviewed, 2021)The interest in implementing digital pathology (DP) workflows to obtain whole slide image (WSI) files for diagnostic purposes has increased in the last few years. The increasing performance of technical components and the ... -
Case Report: Polyvinylpyrrolidone deposition disease from repeated injection of opioid substitution drugs: Report of a case with a fatal outcome
Stalund, Ida Viken; Riise, Gro Nygard; Leh, Friedemann; Bjånes, Tormod Karlsen; Riise, Lars; Svarstad, Einar; Leh, Sabine (Journal article; Peer reviewed, 2021)Background: Intravenous injection of oral opioid substitution drugs (OSD) is widespread among injecting drug users. Several OSDs contain the polymer polyvinylpyrrolidone (PVP) as an excipient. Parenterally administered PVP ... -
Chronic Kidney Disease from Polyvinylpyrrolidone Deposition in Persons with Intravenous Drug Use
Stalund, Ida Viken; Grønseth, Heidi Lønne; Reinholt, Finn P.; Svarstad, Einar; Marti, Hans Peter; Leh, Sabine (Journal article; Peer reviewed, 2022)Background and objectives: Persons with intravenous drug use have a higher risk of developing CKD compared with the general population. In Norway, deposits of polyvinylpyrrolidone have been observed in kidney biopsies taken ... -
A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice
O'Keeffe, Maria; Oterhals, Åge; Weishaupt, Hrafn; Leh, Sabine; Ulvik, Arve; Ueland, Per Magne; Halstensen, Alfred; Marti, Hans Peter; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2023)Purpose The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish ... -
Glomerular proteomic profiling reveals early differences between preexisting and de novo type 2 diabetes in human renal allografts
Kipp, Anne; Marti, Hans Peter; Babickova, Janka; Nakken, Sigrid; Leh, Sabine; Strøm Halden, Thea Anine; Jenssen, Trond; Vikse, Bjørn Egil; Åsberg, Anders; Spagnoli, Giulio; Furriol, Jessica (Journal article; Peer reviewed, 2023)Background Diabetes mellitus (DM), either preexisting or developing after transplantation, remains a crucial clinical problem in kidney transplantation. To obtain insights into the molecular mechanisms underlying PTDM ... -
Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy
Rivedal, Mariell Lossius; Mikkelsen, Håvard; Marti, Hans Peter; Liu, Lili; Kiryluk, Krzysztof; Knoop, Thomas; Bjørneklett, Rune Oskar; Haaskjold, Yngvar Lunde; Furriol Palmer, Jessica; Leh, Sabine; Paunas, Flavia Teodora Ioana; Babickova, Janka; Scherer, Andreas; Serre, Camille Julia; Eikrem, Øystein Solberg; Strauss, Philipp (Journal article; Peer reviewed, 2024)Some patients diagnosed with benign IgA nephropathy (IgAN) develop a progressive clinical course, not predictable by known clinical or histopathological parameters. To assess if gene expression can differentiate between ... -
Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats
Vildmyren, Iselin Thowsen; Oterhals, Åge; Leh, Sabine; Samuelsen, Tor Andreas; Halstensen, Alfred; Marti, Hans Peter; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2022)Background: Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. Objectives: The primary objective of the ... -
Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up
Gjerstad, Ann Christin; Skrunes, Rannveig; Tøndel, Camilla; Åsberg, Anders; Leh, Sabine; Klingenberg, Claus Andreas; Døllner, Henrik; Hammarström, Clara Louise; Bjerre, Anna Kristina (Journal article; Peer reviewed, 2022)Background: There is scarce information on biopsy-verified kidney disease in childhood and its progression to chronic kidney disease stage 5 (CKD 5). This study aims to review biopsy findings in children, and to investigate ... -
Long-Term Outcome in a Phase II Study of Regional Hyperthermia Added to Preoperative Radiochemotherapy in Locally Advanced and Recurrent Rectal Adenocarcinomas
Schem, Baard-Christian; Pfeffer, Frank; Ott, Martin Anton; Wiig, Johan N.; Sletteskog, Nils; Frøystein, Torbjørn; Myklebust, Mette Pernille; Leh, Sabine; Dahl, Olav; Mella, Olav (Journal article; Peer reviewed, 2022-01-29)Hyperthermia was added to standard preoperative chemoradiation for rectal adenocarcinomas in a phase II study. Patients with T3-4 N0-2 M0 rectal cancer or local recurrences were included. Radiation dose was 54 Gy combined ... -
Network-Based Assessment of Minimal Change Disease Identifies Glomerular Response to IL-7 and IL-12 Pathways Activation as Innovative Treatment Target
Eikrem, Øystein Solberg; Lillefosse, Bjørnar; Delaleu, Nicolas; Strauss, Philipp; Osman, Tarig Al-Hadi; Vikse, Bjørn Egil; Debiec, Hanna; Ronco, Pierre; Sekulic, Miroslav; Koch, Even Evjen; Furriol, Jessica; Leh, Sabine; Marti, Hans Peter (Journal article; Peer reviewed, 2023)Background: Minimal change disease (MCD), a major cause of nephrotic syndrome, is usually treated by corticosteroid administration. MCD unresponsiveness to therapy and recurrences are nonetheless frequently observed, ... -
Polyvinylpyrrolidone deposition disease in patients with intravenous opioid use: a case series
Leh, Friedemann; Stalund, Ida Viken; Bjånes, Tormod Karlsen; Ohldieck, Christian; Svarstad, Einar; Leh, Sabine (Journal article; Peer reviewed, 2021)The polymer polyvinylpyrrolidone (PVP) is an excipient widely used in prescription drugs. Depending on the molecular weight (MW), parenterally administered PVP may accumulate in various tissues. Consequently, moderate and ... -
Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN
Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine; Marti, Hans Peter; Berven, Frode Steingrimsen; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2022-03-24)Background: IgA nephropathy (IgAN) is associated with a significant risk of progression to kidney failure. Tubular atrophy is an established important risk factor for progressive disease, but few studies have investigated ... -
Reduced α-galactosidase A activity in zebrafish (Danio rerio) mirrors distinct features of Fabry nephropathy phenotype
Elsaid, Hassan Osman Alhassan; Furriol, Jessica; Blomqvist, Maria; Diswall, Mette; Leh, Sabine; Gharbi, Naouel; Anonsen, Jan Haug; Babickova, Janka; Tøndel, Camilla; Svarstad, Einar; Marti, Hans Peter; Krause, Maximilian (Journal article; Peer reviewed, 2022)Fabry disease (FD) is a rare genetic lysosomal storage disorder, resulting from partial or complete lack of alpha-galactosidase A (α-GAL) enzyme, leading to systemic accumulation of substrate glycosphingolipids with a broad ... -
Systematic reporting of medical kidney biopsies
Leh, Sabine; Dendooven, Amélie (Journal article; Peer reviewed, 2022)The medical kidney biopsy has an important added value in patient care in nephrology. In order to facilitate communication between the pathologist and the nephrologist and optimize patient care, both the content and form ... -
Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing
Delaleu, Nicolas; Marti, Hans Peter; Strauss, Philipp; Sekulic, Miroslav; Osman, Tarig Al-Hadi; Tøndel, Camilla; Skrunes, Rannveig; Leh, Sabine; Svarstad, Einar; Nowak, Albina; Gaspert, Ariana; Rusu, Elena; Kwee, Ivo; Rinaldi, Andrea; Flatberg, Arnar; Eikrem, Øystein Solberg (Journal article; Peer reviewed, 2023)Fabry disease is a rare disorder caused by variations in the alpha-galactosidase gene. To a degree, Fabry disease is manageable via enzyme replacement therapy (ERT). By understanding the molecular basis of Fabry nephropathy ... -
Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy
Nordbø, Ole Petter; Landolt, Lea Zoe; Eikrem, Øystein Solberg; Scherer, Andreas; Leh, Sabine; Furriol, Jessica; Apeland, Terje; Mydel, Piotr Mateusz; Marti, Hans Peter (Journal article; Peer reviewed, 2023)Hypertensive nephrosclerosis (HN) and Type 2 diabetic nephropathy (T2DN) are the leading causes of chronic kidney disease (CKD). To explore shared pathogenetic mechanisms, we analyzed transcriptomes of kidney biopsies from ... -
Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys
Eikrem, Øystein Solberg; Kotopoulis, Spiros; Popa, Mihaela-Lucia; Safont, Mireia Mayoral; Fossan, Kjell Ove; Leh, Sabine; Landolt, Lea; Babickova, Janka; Gudbrandsen, Oddrun Anita; Gilja, Odd Helge; Riedel, Bettina Maria Ingeborg; Schjøtt, Jan Didrik; McCormack, Emmet; Marti, Hans-Peter (Journal article; Peer reviewed, 2021-11-29)The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ...