Browsing Bergen Open Research Archive by Author "Leirgul, Elisabeth"
Now showing items 1-13 of 13
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Association Between Maternal Folic Acid Supplementation and Congenital Heart Defects in Offspring in Birth Cohorts From Denmark and Norway
Øyen, Nina; Olsen, Sjurdur Frodi; Basit, Saima; Leirgul, Elisabeth; Strøm, Marin; Carstensen, Lisbeth; Granström, Charlotta; Tell, Grethe S.; Magnus, Per; Vollset, Stein Emil; Wohlfart, Jan; Melbye, Mads (Peer reviewed; Journal article, 2019-03-19)Background: Evidence linking individual‐level maternal folic acid supplementation to offspring risk of congenital heart defects is lacking. We investigated whether folic acid supplementation in early pregnancy reduces ... -
Birth prevalence of congenital heart defects in Norway 1994-2009—A nationwide study
Leirgul, Elisabeth; Fomina, Tatiana; Brodwall, Kristoffer; Greve, Gottfried; Holmstrøm, Henrik; Vollset, Stein Emil; Tell, Grethe Seppola; Øyen, Nina (Peer reviewed; Journal article, 2014-08-10)Background: The reasons for decreasing birth prevalence of congenital heart defects (CHDs) in several European countries and Canada are not fully understood. We present CHD prevalence among live births, stillbirths, and ... -
Congenital heart defects in Norway - a nation-wide study of birth prevalence, maternal diabetes, and folic acid supplementation in pregnancy
Leirgul, Elisabeth (Doctoral thesis, 2016-05-24) -
Endothelial dysfunction in ME/CFS patients
Sandvik, Miriam Kristine; Sørland, Kari; Leirgul, Elisabeth; Rekeland, Ingrid Gurvin; Stavland, Christina Særsten; Mella, Olav; Fluge, Øystein (Journal article; Peer reviewed, 2023-02-02)Objective: A few earlier studies have found impaired endothelial function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The present study investigated large-vessel and small-vessel endothelial ... -
The influence of region of interest width in fetal 2D-speckle tracking echocardiography late in pregnancy
Omdal, Tom Roar; Khan, Muhammad Umael; Ebbing, Cathrine; Kessler, Jörg; Karlsen, Henriette Odland; Leirgul, Elisabeth; Matre, Knut; Greve, Gottfried (Journal article; Peer reviewed, 2021)Speckle tracking echocardiography is a promising method for assessment of myocardial function in fetal and neonatal hearts, but further studies are necessary to validate and optimize the settings for use in fetal cardiology. ... -
Intake of sucrose‑sweetened soft beverages during pregnancy and risk of congenital heart defects (CHD) in ofspring: a Norwegian pregnancy cohort study
Grønning Dale, Maria Teresa; Magnus, Per; Leirgul, Elisabeth; Holmstrøm, Henrik; Gjessing, Håkon K.; Brodwall, Kristoffer; Haugen, Margaretha; Stoltenberg, Camilla; Øyen, Nina (Peer reviewed; Journal article, 2019)Studies report increased risk of congenital heart defects (CHD) in the offspring of mothers with diabetes, where high blood glucose levels might confer the risk. We explored the association between intake of sucrose-sweetened ... -
Maternal Diabetes, Birth Weight, and Neonatal Risk of Congenital Heart Defects in Norway, 1994-2009
Leirgul, Elisabeth; Brodwall, Kristoffer; Greve, Gottfried; Vollset, Stein Emil; Holmstrøm, Henrik; Tell, Grethe S.; Øyen, Nina (Journal article; Peer reviewed, 2016)Objective: To investigate the association between pregestational or gestational diabetes and offspring risk of congenital heart defects and the association between large-for-gestational-age birth weight and risk of cardiac ... -
Myocardial function including estimates of myocardial work in young adults born very preterm or with extremely low birthweight - a cohort study
Engan, Britt; Omdal, Tom Roar; Greve, Gottfried; Vollsæter, Maria; Leirgul, Elisabeth (Journal article; Peer reviewed, 2023)Background Preterm birth and low birthweight have been associated with increased risk of heart failure and cardiovascular disease in young adulthood. However, results from clinical studies of myocardial function are not ... -
Periconceptional Folic Acid Supplementation and Infant Risk of Congenital Heart Defects in Norway 1999-2009
Leirgul, Elisabeth; Gildestad, Trude; Nilsen, Roy Miodini; Fomina, Tatiana; Brodwall, Kristoffer; Greve, Gottfried; Vollset, Stein Emil; Holmstrøm, Henrik; Tell, Grethe Seppola; Øyen, Nina (Peer reviewed; Journal article, 2015)Background The birth prevalence of congenital heart defects (CHDs) has decreased in Canada and Europe. Recommended intake of folic acid in pregnancy is a suggestive risk-reducing factor for CHDs. We investigated the ... -
Prepregnancy diabetes and offspring risk of congenital heart disease - A nationwide cohort study
Øyen, Nina; Diaz, Lars J; Leirgul, Elisabeth; Boyd, Heather A; Priest, James; Mathiesen, Elisabeth R; Quertermous, Thomas; Wohlfahrt, Jan; Melbye, Mads (Peer reviewed; Journal article, 2016)Background—Maternal diabetes mellitus is associated with an increased risk of offspring congenital heart defects (CHD); however, the causal mechanism is poorly understood. We further investigated this association in a ... -
Systolic myocardial function measured by echocardiographic speckle-tracking and peak oxygen consumption in pediatric childhood cancer survivors—a PACCS study
Engan, Britt; Diab, Simone; Brun, Henrik; Raastad, Truls; Torsvik, Ingrid Kristin; Omdal, Tom Roar; Zamanzad Ghavidel, Fatemeh; Greve, Gottfried; Ruud, Ellen; Edvardsen, Elisabeth; Leirgul, Elisabeth (Journal article; Peer reviewed, 2023)Background: Cancer therapy-related cardiotoxicity is a major cause of cardiovascular morbidity in childhood cancer survivors. The aims of this study were to investigate systolic myocardial function and its association to ... -
Time trends and birth rates in women with congenital heart disease; a nationwide cohort study from Norway 1994–2014
Sandberg, Marit; Fomina, Tatiana; Macsali, Ferenc; Greve, Gottfried; Estensen, Mette-Elise; Øyen, Nina; Leirgul, Elisabeth (Journal article; Peer reviewed, 2024)Background: More women with congenital heart disease (CHD) reach reproductive age, but little is known of their success in having children. We investigated time trends of CHD in women of reproductive age and maternal CHD ... -
Vascular endothelial function assessed by flow-mediated vasodilatation in young adults born very preterm or with extremely low birthweight: A regional cohort study
Engan, Britt; Engan, Mette; Greve, Gottfried; Vollsæter, Maria; Hufthammer, Karl Ove; Leirgul, Elisabeth (Journal article; Peer reviewed, 2021)Background: Preterm birth and low birthweight have been associated with increased risk of cardiovascular disease in young adults. Endothelial dysfunction is established as an early marker for development of atherosclerotic ...