Blar i Bergen Open Research Archive på forfatter "Leiros, Hanna-Kirsti S."
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The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila support a new active site locking mechanism
Leiros, Hanna-Kirsti S.; Fedøy, Anita-Elin; Leiros, Ingar; Steen, Ida Helene (Peer reviewed; Journal article, 2012)Isocitrate dehydrogenase (IDH) catalyzes the oxidative NAD(P)+-dependent decarboxylation of isocitrate into α-ketoglutarate and CO2 and is present in organisms spanning the biological range of temperature. We have solved ... -
Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila
Leiros, Hanna-Kirsti S.; Flydal, Marte Innselset; Martinez, Aurora (Peer reviewed; Journal article, 2013-08-19)Phenylalanine hydroxylase from Legionella pneumophila (lpPAH) has a major functional role in the synthesis of the pigment pyomelanin, which is a potential virulence factor. We present here the crystal structure of lpPAH, ...