Browsing Bergen Open Research Archive by Author "Leiros, Hanna-Kirsti S."

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The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila support a new active site locking mechanism

Leiros, Hanna-Kirsti S.; Fedøy, Anita-Elin; Leiros, Ingar; Steen, Ida Helene (Peer reviewed; Journal article, 2012)

Isocitrate dehydrogenase (IDH) catalyzes the oxidative NAD(P)+-dependent decarboxylation of isocitrate into α-ketoglutarate and CO2 and is present in organisms spanning the biological range of temperature. We have solved ...
Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila

Leiros, Hanna-Kirsti S.; Flydal, Marte Innselset; Martinez, Aurora (Peer reviewed; Journal article, 2013-08-19)

Phenylalanine hydroxylase from Legionella pneumophila (lpPAH) has a major functional role in the synthesis of the pigment pyomelanin, which is a potential virulence factor. We present here the crystal structure of lpPAH, ...