Blar i Bergen Open Research Archive på forfatter "Leiss, Lina Wik"
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Impact of hypoxia on the expression of cell line markers and behavior of cultured glioma cell lines
Leiss, Lina Wik (Master thesis, 2011-06-01)Glioblastoma multiforme (GBM) constitute over 50 % of primary brain tumors in adults. The tumor is heterogeneous and highly infiltrative. Its nature makes it extremely aggressive and incurable. Thus, today's treatment ... -
NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival
Gras Navarro, Andrea; Kmiecik, Justyna; Leiss, Lina Wik; Zelkowski, Mateusz; Engelsen, Agnete; Bruserud, Øystein; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha (Peer reviewed; Journal article, 2014-12)Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms ... -
Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy
Zhu, Huaiyang; Leiss, Lina Wik; Yang, Ning; Rygh, Cecilie Brekke; Mitra, Siddharta S.; Cheshier, Samuel H.; Weissman, Irving L.; Huang, Bin; Miletic, Hrvoje; Bjerkvig, Rolf; Enger, Per Øyvind; Li, Xingang; Wang, Jian (Peer reviewed; Journal article, 2017)Surgical resection is a standard component of treatment in the clinical management of patients with glioblastoma multiforme (GBM). However, experimental therapies are rarely investigated in the context of tumor debulking ... -
Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts
Leiss, Lina Wik; Mutlu, Ercan; Øyan, Anne Margrete; Yan, Tao; Tsinkalovsky, Oleg; Sleire, Linda; Petersen, Kjell; Rahman, Mohummad Aminur; Johannessen, Mireille Kayitesi; Mitra, Siddharta S.; Jacobsen, Hege; Talasila, Krishna Mukharji; Miletic, Hrvoje; Jonassen, Inge; Li, Xingang; Brons, Nicolas H.C.; Kalland, Karl-Henning; Wang, Jian; Enger, Per Øyvind (Peer reviewed; Journal article, 2017-02-07)Background: Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers. Methods: We isolated stromal cells from patient-derived ...