Browsing Bergen Open Research Archive by Author "Lekve, Viola"
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New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells
Viktorsson, Elvar Örn; Aesoy, Reidun; Støa, Sindre; Lekve, Viola; Doskeland, Stein Ove; Herfindal, Lars; Rongved, Pål (Journal article, 2021)Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (3) and myxin (4) exhibit potent and ... -
Phenazine 5,10-dioxide analogues as drugs against acute myeloid leukaemia. -Preclinical documentation for lead selection
Lekve, Viola (Master thesis, 2018-06-29)Background: Acute Myeloid Leukaemia (AML) is a form of cancer that is associated with low survival rates, and where the current treatment is impaired by low tolerance and severe side-effects. Thus, novel treatments are ...