Browsing Bergen Open Research Archive by Author "Lende, Tone Hoel"
Now showing items 1-7 of 7
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Effect of genetic variability in 20 pharmacogenes on concentrations of tamoxifen and its metabolites
Chen, Yuanhuang; Marcath, Lauren A.; Eliassen, Finn Magnus; Lende, Tone Hoel; Soiland, Havard; Mellgren, Gunnar; Helland, Thomas; Hertz, Daniel Louis (Journal article; Peer reviewed, 2021)Background: Tamoxifen, as a treatment of estrogen receptor positive (ER+) breast cancer, is a weak anti-estrogen that requires metabolic activation to form metabolites with higher anti-estrogenic activity. Endoxifen is the ... -
Influence of pre-operative oral carbohydrate loading vs. standard fasting on tumor proliferation and clinical outcome in breast cancer patients - a randomized trial
Lende, Tone Hoel; Austdal, Marie; Varhaugvik, Anne Elin; Skaland, Ivar; Gudlaugsson, Einar; Kvaløy, Jan Terje; Akslen, Lars A.; Søiland, Håvard; Janssen, Emiel; Baak, Jan P.A. (Peer reviewed; Journal article, 2019-11-08)Background: Conflicting results have been reported on the influence of carbohydrates in breast cancer. Objective: To determine the influence of pre-operative per-oral carbohydrate load on proliferation in breast tumors. ... -
Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen
Helland, Thomas; Naume, Bjørn; Hustad, Steinar; Bifulco, Ersilia; Kvaløy, Jan Terje; Sætersdal, Anna Barbro; Synnestvedt, Marit; Lende, Tone Hoel; Gilje, Bjørnar; Mjaaland, Ingvil; Weyde, Kjetil; Blix, Egil Støre; Wiedswang, Gro; Borgen, Elin; Hertz, Daniel Louis; Janssen, Emiel; Mellgren, Gunnar; Søiland, Håvard (Journal article; Peer reviewed, 2021)Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant ... -
Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study
Lende, Tone Hoel; Austdal, Marie; Bathen, Tone Frost; Varhaugvik, Anne Elin; Skaland, Ivar; Gudlaugsson, Einar; Egeland, Nina Gran; Lunde, Siri; Akslen, Lars A.; Jonsdottir, Kristin; Janssen, Emiel; Søiland, Håvard; Baak, Jan P.A. (Peer reviewed; Journal article, 2019-12-04)Background: The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative ... -
Proliferation in operable breast cancer : Aspects of prognostication and relevance of carbohydrate metabolism
Lende, Tone Hoel (Doctoral thesis, 2020-03-06)Breast cancer is the most common malignant disease among women in the Western world. In Norway and the Netherlands, the incidence has more than doubled in the last 50 years, likely due to increased estrogen exposure, higher ... -
The role of microRNAs as predictors of response to tamoxifen treatment in breast cancer patients
Egeland, Nina; Lunde, Siri; Jonsdottir, Kristin; Lende, Tone Hoel; Cronin-Fenton, Deirdre P.; Gilje, Bjørnar; Janssen, Emilius Adrianus Maria; Søiland, Håvard (Peer reviewed; Journal article, 2015-10-14)Endocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. However, resistance to endocrine therapy leads to breast cancer relapse. The recent extension of adjuvant tamoxifen ... -
Simultaneous Quantification of Aromatase Inhibitors and Estrogens in Postmenopausal Breast Cancer Patients
Bertelsen, Bjørn-Erik; Viste, Kristin; Helland, Thomas; Hagland, Magnus; Søiland, Håvard; Geisler, Jürgen; Lende, Tone Hoel; Lønning, Per Eystein; Sagen, Jørn Vegard; Mellgren, Gunnar; Almås, Bjørg (Journal article; Peer reviewed, 2021)Context Currently there are no assays that can simultaneously quantify serum levels of the third-generation aromatase inhibitors (AIs): letrozole, anastrozole, and exemestane, and the ultra-low levels of estrogens in ...