Browsing Bergen Open Research Archive by Author "Lewis, Aurelia Eva"
Now showing items 1-11 of 11
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Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer
Mazloumi Gavgani, Fatemeh; Arnesen, Victoria Smith; Jacobsen, Rhian Gaenor; Krakstad, Camilla; Høivik, Erling Andre; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2018-12-07)The phosphoinositide 3-kinase (PI3K) signalling pathway is highly dysregulated in cancer, leading to elevated PI3K signalling and altered cellular processes that contribute to tumour development. The pathway is normally ... -
Contrasting the phospholipid profiles of two neoplastic cell lines reveal a high PC:PE ratio for SH-SY5Y cells relative to A431 cells
Bariås, Espen; Jakubec, Martin; Førsund, Elise; Hjørnevik, Linda Veka; Lewis, Aurelia Eva; Halskau, Øyvind (Journal article; Peer reviewed, 2023)Lipids have been implicated in Parkinson's Disease (PD). We therefore studied the lipid profile of the neuroblastoma SH-SY5Y cell line, which is used extensively in PD research and compared it to that of the A431 epithelial ... -
DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells
Jacobsen, Rhian Gaenor; Gavgani, Fatemeh Mazloumi; Mellgren, Gunnar; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2016-07-09)DNA topoisomerases (Topo) are multifunctional enzymes resolving DNA topological problems such as those arising during DNA replication, transcription and mitosis. Mammalian cells express 2 class II isoforms, Topoisomerases ... -
Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation
Karlsson, Thomas; Krakstad, Camilla; Tangen, Ingvild Løberg; Høivik, Erling Andre; Pollock, Pamela M.; Salvesen, Helga; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2017-12-16)PTEN loss and constitutive activation of the class I phosphoinositide 3-kinase (PI3K) pathway are key drivers of endometrial tumorigenesis. In some cancer types, PTEN-deficient tumors are reliant on class I PI3K p110β ... -
Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins
Gavgani, Fatemeh Mazloumi; Slinning, Malene Skuseth; Morovicz, Andrea Papdine; Arnesen, Victoria Smith; Turcu, Diana Cornelia; Ninzima, Sandra; D'Santos, Clive S.; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2021)Polyphosphoinositides (PPIns) play essential roles as lipid signaling molecules, and many of their functions have been elucidated in the cytoplasm. However, PPIns are also intranuclear where they contribute to chromatin ... -
Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with high 47S rRNA levels in cancer cells
Mazloumi Gavgani, Fatemeh; Karlsson, Thomas; Tangen, Ingvild Løberg; Papdine Morovicz, Andrea; Arnesen, Victoria Smith; Turcu, Diana Cornelia; Ninzima, Sandra; Spang, Katharina Maria; Krakstad, Camilla; Guillermet-Guibert, Julie; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2021)The class I phosphoinositide 3-kinase (PI3K) catalytic subunits p110α and p110β are ubiquitously expressed but differently targeted in tumours. In cancer, PIK3CB (encoding p110β) is seldom mutated compared with PIK3CA ... -
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer
Mjøs, Siv; Werner, Henrica Maria Johanna; Birkeland, Even; Holst, Frederik; Berg, Anna; Halle, Mari Kyllesø; Tangen, Ingvild Løberg; Kusonmano, Kanthida; Mauland, Karen Klepsland; Øyan, Anne Margrete; Kalland, Karl-Henning; Lewis, Aurelia Eva; Mills, Gordon B.; Krakstad, Camilla; Trovik, Jone; Salvesen, Helga; Høivik, Erling Andre (Peer reviewed; Journal article, 2017-08-31)Mutations of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial cancer. We sequenced exon9 and exon20 of PIK3CA in 280 primary endometrial cancers to assess the relationship ... -
A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction
Karlsson, Thomas; Altankhuyag, Altanchimeg; Dobrovolska, Olena; Turcu, Diana Cornelia; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2016-07)Polyphosphoinositides (PPIns) are present in the nucleus where they participate in crucial nuclear processes, such as chromatin remodelling, transcription and mRNA processing. In a previous interactomics study, aimed to ... -
Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction
Jacobsen, Rhian Gaenor; Gavgani, Fatemeh Mazloumi; Edson, Amanda Jayne; Goris, Marianne; Altankhuyag, Altanchimeg; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2019)Biomolecular interactions between proteins and polyphosphoinositides (PPIn) are essential in the regulation of the vast majority of cellular processes. Consequently, alteration of these interactions is implicated in the ... -
Role of EPAC in cAMP-mediated actions in adrenocortical cells
Lewis, Aurelia Eva; Æsøy, Reidun; Bakke, Marit (Peer reviewed; Journal article, 2016-06-13)Adrenocorticotropic hormone regulates adrenal steroidogenesis mainly via the intracellular signaling molecule cAMP. The effects of cAMP are principally relayed by activating protein kinase A (PKA) and the more recently ... -
SAF-A/hnRNP U binds polyphosphoinositides via a lysine rich polybasic motif located in the SAP domain
Edson, Amanda Jayne; Jacobsen, Rhian Gaenor; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2023)Polyphosphoinositides (PPIn) play essential functions as lipid signalling molecules and many of their functions have been elucidated in the cytoplasm. However, PPIn are also intranuclear where they contribute to chromatin ...